ID A0A455B0B0_PHYMC Unreviewed; 639 AA.
AC A0A455B0B0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Pleckstrin homology domain-containing family H member 3 isoform X3 {ECO:0000313|RefSeq:XP_028342217.1};
GN Name=PLEKHH3 {ECO:0000313|RefSeq:XP_028342217.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028342217.1};
RN [1] {ECO:0000313|RefSeq:XP_028342217.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028342217.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_028342217.1; XM_028486416.2.
DR AlphaFoldDB; A0A455B0B0; -.
DR Proteomes; UP000248484; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13297; PH3_MyoX-like; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR PANTHER; PTHR46049; AGAP003327-PA; 1.
DR PANTHER; PTHR46049:SF5; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..639
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019750323"
FT DOMAIN 95..199
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 237..399
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT REGION 28..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..615
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 639 AA; 69241 MW; FD7FE058A5F164A9 CRC64;
MPLPGGLWWL LCCRRGFTLL HRDYGDGELS GDGDEDEDEE TFELRTPSPA GGGRGPLDVT
LTQPVRSGPV SDRLQSWEET RSLIPEKGPS EDDPDVVVKG WLYREPRGGG ARPWLPPRRA
WFLLTRDSLD QFSSSGKGAR RLGSLVLTSL CSVTGPERRP KETGLWSVTV SGRKHSVRLC
SPRQAEAERW GVALREVIAS KAPLETPTQL LLRDIQESCG DPEAVALIYR RNPILRHTSG
ALYAPLLPLP YGVSAPGPGY APLREEAVRL FLALQALEGA RRPGPLMQGV LQTCRDLPAL
RDELFLQLAK QTSGPAGPPG PPATQDPAAL RYWQLLTCMS CTFRPGGPVR GHLLGHLERT
EQALPDSELA EYARFIRKAL GRTRGRELVP SLAEISALSR RQELLCTVHC PGAGACPVSI
DSHTTAGEVA RELVGRLGLT RSRNAFALYE QRGAQERALA GGTLVADVLT RFENLAAEEA
GLEDPPDSGW RLCLRLHGPL HPEGLSPDGH ELPFLFEQEP GGGAPQKLCL GLGAKAMSLS
RPGETQPVHS VSYGRVAACQ LMGPHTLALR VGESQLLLQS PQVEEIMQLV NAYLANPSPE
RPSSSPPPCQ DLPDTFPPSQ HPGLDEPQGQ SGCLGQLQD
//
