ID A0A455B1F1_PHYMC Unreviewed; 806 AA.
AC A0A455B1F1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Rho guanine nucleotide exchange factor TIAM2-like isoform X6 {ECO:0000313|RefSeq:XP_028341913.1};
GN Name=LOC114485185 {ECO:0000313|RefSeq:XP_028341913.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028341913.1};
RN [1] {ECO:0000313|RefSeq:XP_028341913.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028341913.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_028341913.1; XM_028486112.2.
DR AlphaFoldDB; A0A455B1F1; -.
DR Proteomes; UP000248484; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01230; PH1_Tiam1_2; 1.
DR Gene3D; 6.10.140.680; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR InterPro; IPR040655; TIAM1_CC-Ex.
DR PANTHER; PTHR46001:SF5; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR TIAM2; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF18385; Tiam_CC_Ex; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 492..622
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..269
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 88040 MW; 54BAC9CE70AE7D3D CRC64;
MGNSESQYTL QGSKNHSNTI TGAKQKPCSL KIRGLHAKDD KSLHGWGHGS SGAGYKSRSL
ARSCLSHFKS NQPYASRPGG PSCKVSKGSA YSKHRTNASG SDFQGNDAAF SPENGFHYVG
HPPADNHAAS RACNGHLLNC YGRDESVAST PPGEDRKSPR VLIKTLGKLD GCLRVEFHSG
GPHSAASPGP SGGPVQLLRY SAGSPPSPRA SPAAAARPRS SKGSSLSSES SWYDSPWGPA
GEVSEAEGSF AAPGTPEPEP EPGLHAGFPP RDAPKPFSQS ASLSSLREPY PDATLGSLAP
AALRLSDDYV GTRASLSARV SFASDMDVPA RVERGEPGQF ASFTLPCRKS RALSEEPSKK
DTLKARMRRI SDWTGSLSRK KRRLQEPRSK EGSDYFDSRS DGLNVDVQGP SQASASLWSG
SAQILSHRSE SAHAIGNDPL QQNIYENFMR ELEMSRTNTE NLETSTETAE SSSDSLSSLE
QLDLLFEKEQ GVVRKAGWLF FKPLVTLQKE RKLELVARRK WKQYWVTLKD RSSGPVIRTV
LLSFTGCTLL FYETYGKNSM DQSSTPRCAL LAEDSIVQAV PEHPKKENVF CLSNSFGDVY
LFQATSQTDL ENWVTAIHSA CASLFAKKHG KEDTVRLLKN QTRNLVQKID MDSKMKKMAE
LQLSVVSDPK NRKAIENQIQ QWEQNLEKFH MGLFRMRCYL ASLQGGELPN PKSLLAAASR
SSKLALGRLG VLSVSSFHAL VCSRDDSALR KRTLSLTQRG RHKKGLFSSL KGLDTLARKG
KEKRPSITQN ITFKNCGCGL PWWRSG
//
