ID A0A455B242_PHYMC Unreviewed; 389 AA.
AC A0A455B242;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=MAGUK p55 subfamily member 2 {ECO:0000313|RefSeq:XP_028342832.1};
GN Name=LOC102978278 {ECO:0000313|RefSeq:XP_028342832.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028342832.1};
RN [1] {ECO:0000313|RefSeq:XP_028342832.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028342832.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004202}.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR RefSeq; XP_028342832.1; XM_028487031.2.
DR AlphaFoldDB; A0A455B242; -.
DR STRING; 9755.ENSPCTP00005031024; -.
DR KEGG; pcad:102978278; -.
DR InParanoid; A0A455B242; -.
DR OrthoDB; 2873706at2759; -.
DR Proteomes; UP000248484; Unplaced.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd12037; SH3_MPP2; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR035602; MPP2_SH3.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122:SF35; MAGUK P55 SUBFAMILY MEMBER 2; 1.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR Pfam; PF02828; L27; 2.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 25..76
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 77..135
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 157..236
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 242..310
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT NON_TER 389
FT /evidence="ECO:0000313|RefSeq:XP_028342832.1"
SQ SEQUENCE 389 AA; 42632 MW; 13282DB6105EB0B9 CRC64;
MAGSPGCGAS LEGISLGSSE EAELRREAMQ QVLDNLGSLP NATGAAELDL IFLRGIMESP
IVRSLAKAHE RLEETKLEAV RDNNLELVQE ILRDLAQLAE QSSTAAELAR ILQEPHFQSL
LETHDSVASK TYETPPPSPG LDPTFSNQPV PPDAVRMVGI RKTAGEHLGV TFRVEGGELV
IARILHGGMV AQQGLLHVGD IIKEVNGQPV GSDPRALQEL LRNTSGSVIL KILPSYQEPH
LPRQVFVKCH FDYDPARDSL IPCKEAGLHF SAGDLLQIVN QDDANWWQAC HVEGGSAGLI
PSQLLEEKRK AFVKRDLELT PTSGALCGSI SGKKKKRMMY LTTKNAEFDR HELLIYEEVA
RMPPFRRKTL VLIGAQGVGR RSLKNKLIM
//
