ID   A0A455B345_PHYMC        Unreviewed;       656 AA.
AC   A0A455B345;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Rap guanine nucleotide exchange factor-like 1 isoform X3 {ECO:0000313|RefSeq:XP_028342959.1};
GN   Name=RAPGEFL1 {ECO:0000313|RefSeq:XP_028342959.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028342959.1};
RN   [1] {ECO:0000313|RefSeq:XP_028342959.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028342959.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_028342959.1; XM_028487158.2.
DR   AlphaFoldDB; A0A455B345; -.
DR   Proteomes; UP000248484; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF230; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR-LIKE 1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT   DOMAIN          424..653
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          1..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          620..656
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        628..649
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   656 AA;  72091 MW;  9023C378F9993B56 CRC64;
     MKPLEKFLKK QTSQLAGRTV AGGPGGGPGS CGGPGGGGGP GGGGGLAGGP RPLQRRQSVS
     RLLLPAFLRE PLAEPGLEQP PEEDGGEPAG VAEDLGSGGP CWLQLEEVPG PGPLGGGGPL
     RSPSSYSSDE LSPGEPLTSP PWAPLGAPER PEHLLNRVLE RLAGGVTRDS AASDILLDDI
     VLTHSLFLPT EKFLQELHQY FVWAGGMEGP EGLGRKQACL AMLLHFLDTY QGLLQEEEGA
     GRIIKDLYLL IMKDESLYQD LREDTLRLHQ LVETVELKIP DESQLPSKQV KPLFRHFRRI
     DSCLQTRVAF RGSDEIFCRV YMPDHSYVTI RSRLSASVQD ILGSVTEKLQ YSEEPAGRED
     SLILVAVASS GEKVLLQPTE DCVFTTLGIN SHLFACTRDS YEALVPLPEE IQVSPGDTEI
     HRGEPEDVAN HLTAFHWELF RCVHELEFVD YVFHGERGRR ETANLELLLQ RCSEVTHWVA
     TEVLLCEAPG KRAQLLKKFI KIAAICKQNQ DLLSFYAVVM GLDNAAVSRL RLTWEKLPGK
     FKNLFRKFEN LTDPCRNHKS YREVISKMKP PVIPFVPLIL KDLTFLHEGS KTLVDGLVNI
     EKLHSVAEKV RTVRKYRSRP LSALPPEPSQ QPCHSSSHHP PQTLGPTGSV SAAARP
//