ID   A0A455B3Y6_PHYMC        Unreviewed;       579 AA.
AC   A0A455B3Y6;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Apoptosis-inducing factor 1, mitochondrial isoform X3 {ECO:0000313|RefSeq:XP_028338731.1};
GN   Name=AIFM1 {ECO:0000313|RefSeq:XP_028338731.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028338731.1};
RN   [1] {ECO:0000313|RefSeq:XP_028338731.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028338731.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + H(+) + NADH = AH2 + NAD(+); Xref=Rhea:RHEA:11356,
CC         ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:17499,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC         Evidence={ECO:0000256|ARBA:ARBA00000272};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase family.
CC       {ECO:0000256|ARBA:ARBA00006442}.
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DR   RefSeq; XP_007103107.1; XM_007103045.1.
DR   RefSeq; XP_028338731.1; XM_028482930.2.
DR   AlphaFoldDB; A0A455B3Y6; -.
DR   Proteomes; UP000248484; Chromosome 21.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.390.30; -; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR029324; AIF_C.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR   PANTHER; PTHR43557; APOPTOSIS-INDUCING FACTOR 1; 1.
DR   PANTHER; PTHR43557:SF4; APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL; 1.
DR   Pfam; PF14721; AIF_C; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00368; FADPNR.
DR   PRINTS; PR00411; PNDRDTASEI.
DR   SMART; SM01353; AIF_C; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR   SUPFAM; SSF55424; FAD/NAD-linked reductases, dimerisation (C-terminal) domain; 1.
PE   3: Inferred from homology;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          102..427
FT                   /note="FAD/NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF07992"
FT   DOMAIN          431..560
FT                   /note="Mitochondrial apoptosis-inducing factor C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14721"
FT   REGION          66..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          479..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        480..512
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   579 AA;  63076 MW;  B138FCA1A60DF2C0 CRC64;
     MCNLFQRWHV PLELQMTRQM TSSGASGGKI DNSVLVLIVG LSTIGAGAYA YKTIKDDQKR
     YNERISGLGL TPEEKQKRAT SSAPEGEPVP EVRVPSHIPF LLIGGGTAAF AAARSIRARD
     PGARVLIVSE DPELPYMRPP LSKELWFSDD PNVTKTLRFK QWNGKERSIY FQPPSFYVSA
     QELPHIENGG VAVLTGKKVV QLDVRGNVAK LNDGSQITYE KCLIATGGTP RSLSAIDRAG
     AEVKSRTTLF RKIGDFRTLE KISREVKSIT IIGGGFLGSE LACALGRKAR ASGTEVIQLF
     PEKGNMGKIL PEYLSNWTME KVRQEGVKVL PSAIVQSVGV SGGRLLIKLK DGRKVETDHI
     VAAVGLEPNV ELAKTGGLEI DSDFGGFRVN AELQARSNIW VAGDAACFYD IKLGRRRVEH
     HDHAVVSGRL AGENMTGAAK PYWHQSMFWS DLGPDVGYEA IGLVDSSLPT VGVFAKATAQ
     DNPKSATEQS GTGIRSESET ESEASEITLP PSSPVVPQAP AQGEDYGKGV IFYLRDKVVV
     GIVLWNIFNR MPIARKIIKD GEEHEDLNEV AKLFNIHED
//