ID A0A455B4B4_PHYMC Unreviewed; 4359 AA.
AC A0A455B4B4;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 2.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Intermembrane lipid transfer protein VPS13D {ECO:0000313|RefSeq:XP_028343637.2};
GN Name=VPS13D {ECO:0000313|RefSeq:XP_028343637.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028343637.2};
RN [1] {ECO:0000313|RefSeq:XP_028343637.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028343637.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR RefSeq; XP_028343637.2; XM_028487836.2.
DR STRING; 9755.ENSPCTP00005003114; -.
DR KEGG; pcad:102982429; -.
DR Proteomes; UP000248484; Chromosome 3.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd14306; UBA_VP13D; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041969; VP13D_UBA.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF141; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF00627; UBA; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
DR Pfam; PF06650; VPS13_VAB; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2604..2647
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 376..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1717..1742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2042..2075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 71..98
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 716..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2042..2059
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4359 AA; 488659 MW; C395C8E261269340 CRC64;
MHIGAVELEN LPLKKDALKE LELPFEVKAG LIGKVTLQIP FYRPHVDPWV ISISSLHLIG
APEKIQDFND EKEKLLERER KKDLLQALEE KWKNERQQKG ESYWYSVTAS VVTRIVENIE
LKIQDVHLRF EDGITNPSHP FAFGVCIKNV SMQNAVNEPV QKLMRKKQLD VAEFSIYWDV
DCTLLGDLPQ VELQEAMDKS QESRNHHYIL EPVCASALLK RNCSKEPLRS RHTPRIECDI
HLETIPLKLS QLQYRQIMEF LKELERKERQ LKFRKWKPKV AVSENCREWW YFALNANLHE
IREQRTRCTW DFLLHRARDA VSYTDKYFTK LKGGLLSADD KEEVCRIEEE QSFEELKILR
ELVHERFHKQ EELAESLREP QLYSPGESPG DPEPSGGSGM LQYLQSWFPG WGGWYGQQTP
EGKPVEGLTA EQHEHWTPEE ILGSEEFFDP TADASCMNTY TKRDHVFAKL NLQLQRGTVT
LLHQEQGAAQ MNQSAFMQLE FSGVKLLAES LPRRNSSLLS VRLGGLFLRD LATEGTIFPL
LVFPNPQKEV GRVSQSFGLQ TASADRSDHY PAADPDDPVF EMLYERNPVH SHFERRLNVS
TRPLNIIYNP QAIKKVADFF YKGKVHTSGF GYQSELELRV AEAARRQYNR LKMQTKAEIR
QTLDRLLVGD FIEESKRWTV RLDISAPQVI FPDDFKFKNP VLVVVDLGRM FLTNTQDDSK
RKSGDGSASE ENQFSDDEYK TPLATPPNTP PPETSSSNRE QTPPFSGVEF SEEQLQAHLM
STKMYERYSL SFLDLQIMVG RVKDNWKHVQ DIDVGPTHVV EKFNVHLQLE RRLIYTSDPK
YPGAVLSGNL PDLKIHINED KISALKNCFA LLTTPEMKTF DTQIKEKIFP HGGQRGSLQD
SVMNLTQSIV MLEQHTREVL VESQLLLAEF KVNCMQLGVE SNGRYISVLK VFGTNAHFVK
RPYDAEVSLT VHGLLLVDTM QTYGADFDLL MASHKNLSFD VPTGSLRDSR AQSPVSGSNV
AHLTNAATLN DRSATSVSLD RILTKEQESL IKLEYQFVSS ECPSMNLDST LQVISLQVNN
LDIILNPETI VELIGFLQKS FPKEKDDLSP QPLMTEFERS FREQGTYQST YEQNTEVAVE
IHRLNLLLLR TVGMANGEKY GRKIATASIG GTKVNVSMGS TFDMNGSLGC LQLMDLTQEN
VKNQYVVSIG NSIGYENIIS DIGYFESVFV RMEDAAVTEA LSFTFVEKFK QECFLNLKMA
SLHYNHSAKF LKELTLSMDE LEENFRNMLK SAATKVTTVL ATKTAEYSEM VSLFETPRKA
RECFILEENE TYGFGLGASH SDTVKLILNI NIESPVVSIP RKPGSPELLV GHLGQIFIRN
FVAGDDESRS DRLQVEIKDI KLYSLNCTQL AGREGPGPEV SRAFCPPSGS ASASSQEEAH
FTRHDFFESL HRGQAFHILN NTTIQFKLEK IPIERESEFT FSLSPDDLGT SSIMKIEGKF
VNPVQVVLAK HVYEQVLQTL DNLVYSEDLN KLPVSATSSP CPNSPLPSLG TCGEPSIERK
ENGLFSHCSL SNSSQKSLSF KEVRSFTQIQ ANFCISELQV QLSGDLTLGA QGLVSLKFQD
FEVEFSKDHP QTLSIQIALR SLLMEDLLEK NPDSKYKNLM VSRGAPKPSS LAQKEYLSQS
CPSVSNVEYP DMPRSLPSHM EEAPNVFQLY QRPISASRKK QKEVQDKDCP LTPPPSPTVE
EPKILAGRSK FDDSLVHINI FLVDKKHPEF SSSYNRVNRS IDVDFNCLDV LITLQTWVMI
LDFFGIGSTA NNHAVKVPPE DILQNVKPES SALIESELQD PVNTKLDLKV HSLSLVLNKT
TSELAKANVS KLVAHLEMIE GDLALQGSIG SLSLSDLTSH GEFYRERFTT SGEEALIFQT
FKYGGPDPLL RREYDIRVSL QMASVQYVHT QRFQAEVVAF IQHFTQLQDV LGRQRAAIEG
QTVRDQAQRC SRVLLDIEAG APVLLIPESS RSNNLIVANL GKLKVKNKFL FAGIPGTFTL
QDKESVPSAS PTGTPKHSVR KMTSVEDPKG THSEGLFMMP PVGMSLGSLK SEFVPSTSTK
QQGQQATPSV GQVSRIPEDH VCLLDCIVVD LQDMDIFAAE RHPREYTKAL EDSSGDLIFP
SYFVRQTGGS LLTEPCRLKL QVERNLDKEI SHTVPDISIH GNLSSVHCSL DLYKYKLIRG
LLENNLGEPI EEFMRPYDLQ DPRIHTVLSG EVYTCMCFLI DMVNVSLELK DPKGKEGAGS
LARFDFKKCK LLYESFSNQT KSVNLVSHSM MAFDTRYAGQ KTSPGMTNVF TCIFQPSKNS
STTQGSIQIE LHFRSTKDSS CFTVVLNNLR VFLIFDWLLL VHDFLHTPSD IKKQTKVTPS
RHRNSSSESA VIPKTVKSGV VTKRSSLPVS TERHLEVKVN VTGTEFVVVE DVSCFDTNAI
ILKGTTVLTY KPRFVDRPFS GSLFGIEVFS CRLGNEQDTA LSIVDPVQIQ VELVGNSSYQ
NSSGLMDAFN SEDFPPVLEI QLQALDIRLS YNDVQLFLAI AKSIPEQANA AVPDTVALDA
NSFSSYLPGA SRRGEEIREG TRHTLDPVLE LQLARLQELG FGMDDCRKAL LVCQGQLKKA
ASWLFKNAEP LTSLSLASNS RESQVAAPAR LISGVEMKAE SVCICFIDDC MDCDVPLAEL
TFSRLNFLQH VRTSPEGYAH FTLSGDYYNR ALSGWEPFIE PWPCSVSWQQ QAASRLHPPR
LKLEAKAKHR LDINITSVLT DQYISTKESW MADYCKQDKE IDSTTSEDWM GSSVDPPCFG
QSLPLVYLRT RSTASLTNLE HQIYAREMKA PKRRQPFVPF ALRNHTGCTL WFATLTTTPT
RAALSHSGSP GVAPEGNGTF LDDAHNVSEW REVLTGEEIP FEFEARGKLR HRHTHDLRIH
QLQVRVNGWE QVSPVSVDKV GTFFRYAAPD KNSSSSTIGS PSSRTNIIHP QVYFSSLPPV
RVVFAVTMEG SARKVITVRS ALIVKNRLET PMELRLDSPS APDKPVVLPA IMPGDSFAVP
LHLTSWRLQA RPKGLGVFFC KAPIHWTNVV KTTEVSSSKR ECHSMDAEKS RFFRFCVAIK
KENYPDYMPS NIFSDSAKQI FRQPGHTIYL LPTVVICNLL PCELDFYVKG MPIKGTLKPG
KEVALHTADT SQNIELGVSL ENFPLCKELL IPPGTQNYMV RMRLYDINRR QLNLTIRIVC
RAEGSLKIFI SAPYWLVNKT GLPLIFRQDN ARMDAAGQFE EHELARSLSP LLFCYADKEQ
PSLCTMRIGR GIHPEGMPGW CQGFSLDGGS GVRALRVIQQ GNRPGLIYNI GIDVKKGRGR
YIDTCMVIFA PRYLLDNKSS HKLAFAQREF ARGQGTANPE GYISTLPGSS VVFHWPRNDY
DQLLCVRLMD VPNCIWSGGF EVNKNNSFHI NMRDTLGKCF FLRVEITLRG ATYRISFSDT
DQLPPPFRVD NLSKVPVVFT QHGVAEPRLR TEVKPMTSLD YAWDEPTLPP FITLTVKGAG
SSEINCNMND FQDNRQLYYE NFIYIAATYT FSGLQEGTGR PVASNRAITC AELVLDVSPK
TQRVILKKKE PGKRSQLWRM TGTGMLAHEG SSVPHNPSKP LAARPTEGSA ILDIAGLAAV
TDNRYEPLML RKPDRRRSTT QTWSFREGKL TCGLHGLVVQ AKGGLSGLFD GAEVVLGPDT
SMELLGPVPP EQQFINQKMR PGSGMLSIRV IPDGPTRVLQ ITDFSQRKSD RSSYEVDELP
VTDQELQKLK NPDTEQELEV LVKLEGGIGL SLINKVPEEL VFASLTGINV HYTQLATSHM
LELSIQDVQV DNQLIGTTQP FMLFVTPLSN ENEVIETGPA VQVNTVKFPS KSALTNIYKH
LMVTAQRFTV QIEEKLLLKL LSFFGYDQAE SEVEKYDENL HEKTAEQGGT PIRYYFENLK
ISIPQIKLSV FTSNKLPLDL KALKSTLGFP LIRFEDAVIN LDPFTRVHPY ETKEFIINDI
LKHFQEELLS QAARILGSVD FLGNPMGLLN DVSEGVTGLI KYGNVGGLIR NVTHGVSNSA
AKFAGTLSDG LGKTMDNRHQ SEREYIRYHA ATSGEHLVAG IHGLAHGIIG GLTSVITSTV
EGVKTEGGVS GFISGLGKGL VGTVTKPVAG ALDFASETAQ AVRDTATLSG PRTQAQRVRK
PRCCTGPQGL LPRYSESQAE GQEQLFKLTD NIQDEFFIAV ENIDSYCVLI SSKAVYFLKS
GDCLDREAIF LEVKYDDLYH CLVSKDHGKV YVQVTKKAVN TSSGVSMPGP SHQKPLVHVK
SEVLAVKLSQ EINYAKSLYY EQQLMLRLNE NQEQLELDS
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