ID A0A455B5W0_PHYMC Unreviewed; 651 AA.
AC A0A455B5W0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 {ECO:0000313|RefSeq:XP_028344320.1};
GN Name=IKBKE {ECO:0000313|RefSeq:XP_028344320.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028344320.1};
RN [1] {ECO:0000313|RefSeq:XP_028344320.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028344320.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_028344320.1; XM_028488519.1.
DR AlphaFoldDB; A0A455B5W0; -.
DR Proteomes; UP000248484; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:UniProt.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd17128; Ubl_IKKE; 1.
DR Gene3D; 1.20.1270.420; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR041309; TBK1_CCD1.
DR InterPro; IPR041087; TBK1_ULD.
DR PANTHER; PTHR22969; IKB KINASE; 1.
DR PANTHER; PTHR22969:SF10; INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF18394; TBK1_CCD1; 1.
DR Pfam; PF18396; TBK1_ULD; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_028344320.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..315
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 38
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 651 AA; 72690 MW; B39A252975C20009 CRC64;
MQSTVNYLWH TDDLLGQGAT ASVYKARNKK SGELVAVKVF NTASYLRPHE VQVREFEVLR
KLNHQNIIKL FAVEEMGGSR QKVLVMEYCS SGSLLSVLES PENAFGLPED EFLVVLRCVV
AGMNHLRENG IVHRDIKPGN IMRLVGEEGQ SIYKLTDFGA ARELDDDEKF VSVYGTEEYL
HPDMYERAVL RKPQQKAFGV AVDLWSIGVT LYHAATGSLP FVPFGGPRRN KEIMYRITTE
KPAGAIAGTQ RLENGPLEWS YTLPVTCQLS MGLQSQLVPI LGNILEVEQA KCWGFDQFFA
ETSDILQRVV VHVFSLPQAV MHHVYIHAHN TIAIFLEAVY KQTNVAPQHQ EYLFEGHLCV
LEPSLSAQHI AHTTASSPLT LFSMVSETPK GLAFRDPALD IPKFVPKVDL QADYNTAKGV
LGAGFQALRL AQALLAGQEL MLRGLHWFVE ILQATCRRTL EVTRMALLFL SSSLGTESNV
PGVPEIQELK RAAELRSKLR TLAEVLSRCS HNITETKTTL SKLSSELMKN RDQVHEDRSI
QQIQCCLDKM YLIYKQFKKS RMRPGEPQGE QNTHALPSLP PSFPWVSWLS LTLHPVALLE
AHYAGGAPWC PGASGLGQGR CLQAACTPVR DMKPFHLCLL PHRGSAEAWM L
//
