ID A0A455B986_PHYMC Unreviewed; 4973 AA.
AC A0A455B986;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=[histone H3]-lysine(4) N-methyltransferase {ECO:0000256|ARBA:ARBA00023620};
DE EC=2.1.1.364 {ECO:0000256|ARBA:ARBA00023620};
GN Name=KMT2C {ECO:0000313|RefSeq:XP_028345347.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028345347.1};
RN [1] {ECO:0000313|RefSeq:XP_028345347.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028345347.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) +
CC N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_028345347.1; XM_028489546.2.
DR Proteomes; UP000248484; Chromosome 5.
DR GO; GO:0044666; C:MLL3/4 complex; IEA:InterPro.
DR GO; GO:0140999; F:histone H3K4 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15696; ePHD1_KMT2C; 1.
DR CDD; cd15697; ePHD2_KMT2C; 1.
DR CDD; cd22026; HMG-box_KMT2C; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15594; PHD2_KMT2C; 1.
DR CDD; cd15511; PHD3_KMT2C; 1.
DR CDD; cd15596; PHD4_KMT2C; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd15600; PHD6_KMT2C; 1.
DR CDD; cd19171; SET_KMT2C_2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 7.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR000637; HMGI/Y_DNA-bd_CS.
DR InterPro; IPR041967; KMT2C_ePHD1.
DR InterPro; IPR041968; KMT2C_ePHD2.
DR InterPro; IPR047004; KMT2C_PHD2.
DR InterPro; IPR047003; KMT2C_PHD4.
DR InterPro; IPR047005; KMT2C_PHD6.
DR InterPro; IPR037877; PHD3_KMT2C.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE 2C; 1.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00628; PHD; 4.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00249; PHD; 8.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50216; DHHC; 1.
DR PROSITE; PS51805; EPHD; 2.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS00354; HMGI_Y; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 6.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 228..332
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 342..392
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 345..390
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 389..439
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 465..521
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 952..1005
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1002..1052
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1079..1134
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 4461..4569
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 4833..4949
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 4957..4973
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1188..1298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1377..1403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1452..1476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1617..1644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1722..2461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2529..2551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2589..2750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2801..2876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2933..2972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3212..3238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3275..3297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3328..3421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3442..3815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3833..3885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4031..4072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4084..4113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..26
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1377..1395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1460..1476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1620..1644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1722..1742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1743..1770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1771..1828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1856..1871
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1930..1970
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1972..1991
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2042..2060
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2089..2110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2118..2137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2162..2186
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2187..2205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2212..2232
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2309..2325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2337..2384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2394..2408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2437..2461
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2631..2655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2663..2691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2692..2714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2801..2817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2818..2834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2835..2858
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2943..2968
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3341..3385
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3400..3421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3447..3465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3484..3518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3578..3596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3667..3681
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3728..3752
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3833..3849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3850..3885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4973 AA; 543519 MW; A079D74B7C031D93 CRC64;
MSSEEDKSAE QPQPPPPPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR ARKKPRSRGK
STVEDEDSMD GLETTETENT VETAEIKEQS AEEDAEAEVD SSKQPVPDFQ RSVSEESATS
LVSVGIEAKI SEQLCAFCYC GEKSSLGQGD LKQFRVTPGF ILPWKNQPSN KKDVDDNSSG
TCEKIQNSTP RKQRGQRKER SPQQNIVSCV SVSTQTASDD QAGKLWDELS LVGLPDAIDV
QALFDPTGTC WAHHRCVEWS LRVCQMEEPL LVNVDRAVVS GSTERCAFCK HLGATIKCCE
EKCTQMYHYP CAAGAGTFQD FSHFFLLCPE HIDQAPERSK EDANCAVCDS PGDLLDQFFC
TTCGQHYHGM CLDIAVTPLK RAGWQCPECK VCQNCKQSGE DSKMLVCDTC DKGYHTFCLQ
PVMKSVPTNG WKCKNCRICV ECGTRSSSQW HHNCLVCDSC YQQQDNLCPF CGKCYHPELQ
KDMLHCNMCK RWVHLECDKP TDHELDSQLK EEYICMYCRH LAEMDPLQPG DEVEMAELTT
DCNNEMEVEG PEDHMVFLEQ AVNKDVGGQQ PAPGIVPDAA HIRTGEQQRS DPPESRGTRG
LLIAESSQDK MNPELENQIS REVDSEEMEM PPKVVHTCSA DQNENKMEVT DGAEALAPQV
AVQPGEVHLL GGPNVAASPE ESRPPGVNSE SVTVPSPGGE GTALCSKAQL AIEGVPEEME
QKENPEPSTA FMDFEVAPAI ESCVKDGVCQ ESKSVKLPSE TESSFSSAAG ISKANASSSP
ALSSDLPSHD MLHSYPSTPS ASAGNIMPTT YISVTPKIGM GKPAITKRKF SPGRPRSRQG
AWSTHNTVSP PSWSPDISEG REIFKPRQLP GSAIWSIKVG RGSGFPGKRR PRGAGLSGRG
GRGRSKLKSG IGAVVLPGVS AADISSNKDE EENSMHNTVV LFSSSDKFTL HQDMCVVCGS
FGQGAEGRLL ACSQCGQCYH PYCVSIKITK VVLSKGWRCL ECTVCEACGK ATDPGRLLLC
DDCDISYHTY CLDPPLQTVP KGGWKCKWCV WCRHCGAASA GLRGEWQNNY TQCAPCASLS
SCPACCRSYR EEDLILQCRQ CDRWMHAVCQ NLNTEEEVEN VADIGFDCSM CRPYMPTSND
PPKTYTQDGV CLTESGMTQL QSLTVTVPRR KRSKPKLKLK IINQNSVAVL QTPPDIQSEH
SRDGEMDDSR EGELMDCDGK SESSPEREAV DDETKGVEGT EGVKKRKRKP YRPGIGGFMV
RQRSRTGQGK TKRSVIRKDS SGSISEQLPS RDDGWSEQLP DTLVDESVSV TENTEKTKKR
YRKRKNKLEE IFPAYLQEAF FGKDLLDTTR QNKLSLDNLS EDTAQLSYKT NMNPNFLDPS
LDPLLSSSST PAKPGTHGTA DDPLADISEV LNTDDDILGI ISDDLAKSVD HSGLDLCTFQ
VESSSCPFAG IDVGAGTDDP SSLPQPSVNQ SSRPLSEEQL DGILSPELDK MVTDGKIFAL
HLGFLKDMRA ILGKLYKIPE LGGKDVEDLF TAVLSPAATQ PASIPQPPVP PLLPTHTQGM
SPLGKRHVFS RMPLMNGLIG PSPHLAHNSL PPGSGLGTFS AVAQSPYTDA RDKNPAFNPM
ASDPNGSWTS SAPTMEGEND TMSNAQRSTL KWEKEEALGE MATVAPVLYT NINFPNLKEE
FPDWTTRVKQ IAKLWRKASS QERAPYVQKA RDNRAALRIN KVQMSNDSMK RQQQQDSIDP
SSRVDSDLFK DPLKQRESEH EQEWKFRQQM RQKSKQQAKI EATQKLEQAK NEQQQLGSQP
LLGRSGSDTP TGGVQSPLTP QPGNGSMSPA PSFHKDLFAK QLPGAPTSAP SDDVFVKPHA
PPPPPAPSRI SIPESLPQAQ TPQPPSPQMF SPGSSNSRPP SPVDPYAKMV GTPRPPPGGH
GFSRRNSALV ENCAPLSSVS RPTQMSETTA NRPSPVRDLC SSSTASSDPY AKPPDTPRPV
MTDPFPKPLG LPRSPVVSEQ TAKGPLASGT NDHFAKPSPR ADAFQRQRIP DPYARPLLTP
APLDSGPGPF KAPMQPPPSS QDPYGSVSQA PRRLSVDPYE RPALTPRPVD NFSHNQSSDP
YSQSPITPHP AMNESFAHPS RAFSQPGTIS RPTSQDPYSQ PPGTPRPVVD SYSQPPGTSR
SNPDPYSQPP GTPRPTVDPY SQQPPTPRPS AQADLFVTSA ANQRRSDPRG HPPGTPRPGV
SVPYPQPPAV PRPRISEGFA RSSATRPVLA PSQDPFLQAA QNRGAALPGP LVRPPDACSQ
TPRPPGPGLS DTFSRVSPSA PRDPYEQPPM TQRPQSDSFG TSQVAHDVAE QPRPRSEGSF
SAPSSSPMNS QGQQFSGVSQ LPGPVPTSGV TDTQSTVNMS QADTEKLRQR QKLREIILQQ
QQQKKLAGRQ EKGSQDPGPV PHPGPLQHWQ PESVSQAFTR PPPPYPGSIR SPIGPPLGPR
YAVFPKDPRG PYTPDVTGMG MRPHGFRFGF PGGSHGTLSS QERFLVPPQQ IQGSGFPPQL
RRSMSVDMPR PLNNSQTNNP GGLPPHFSPQ SLSVQQHNIL GQAFIELRHR TPDGRPRMPF
PASPGNVIEA PSHPRHGNFI PRPDFPGPRH TDPMRRPSQG LPHQLPVHPN LEQVPPSQQE
QSHPVHSSSV VMRSLSHSLG GEFSEAPLST SAPAETTSDN LQITTQSSGG LEEKLDSDDP
SVKELDVKDL EGVEVKDLDD EDLENLNLDT EDGKGDELDT LGNLETNDPN LDDLLRSGEF
DIIAYTDPEL DLGDKKSMFN EELDLNVPID DKLDNQCVSV EPPKKEQDDK SMVPSDKHSS
WKKSTVSSEI KTEVLSPDSK GETKCESEKS DEGKDTVDAA CPQDPAHTDG NDGEQASLQS
CDADLLEKRT NRETAGSNTG VRGSTQLPAE DVINSCSIPG STPVLSSLLA NEKSDNSDVR
PLGSPPPTLP ASPSSHVSSL PPPLMTPPGH ALDNTLNSDV TVVPRLNHTF PQGVQASPGF
IQGQPTVHRG FGTAKPVNQT VPLTSQSAPS GVSGPQQLMV PQTAAQQNRE RPLLLEEQPL
LLQDLLDQER QEQQQQRQMQ AMIRQRSEPF FPNIDFDAIT DPIMKAKMVA LKGINKVMAQ
NNMGMPPMVM NRFPFMGQSV TGTQTGDGQT LLPQAVTQDG SITHQISRPN PPNFGPGFVN
DSQRKQYEEW LQETQQLLQM QQKYLEEQIG AHRKSKKALS AKQRTAKKAG REFPEEDAEQ
LKHVTEQQSM VQKQLEQIRK QQKEHAELIE DYRIKQQQQQ QCAPAPPTAM PGVQPQLPLV
PGVPPPAMSQ PGFPMAPLRL QHQRHTTVIS GRTTSPARTP GLPGWQPPGA PHHPLDPPGV
QPPVAQLPVK TCPPAPGPVS NAKPQSGPPP RVEFDDNNPF SESFQERERK ERLREQQERQ
RIQLMQEVDR QRALQQRMEM EQHGLMGSEL SSRTPVSQIP FYTSDLPCDF TQPPRPLQQP
PQQPQHAGPV LQQQNIQQGS VDSPPTPNFM QTSERRQMGP PSFVPDSPSI PGGSPNFHSV
KPVLGGVPGA GFQQSPVRPP FTPALPAAPP VANSSLPCGQ DPAVSRGQSY PGSAPSLIQL
YSDIIPEEKG KKKRTRKKKK DDDAESTKAP STPHSDVAAP PTPGVSEATS APAANTPGEL
PRQGEPEPVE PGGPSPDPAA GPLCTEPENE LPSGDFARGT PGQQTCASSE VDKRPIDAPA
PTGEVKLEPA EPEQRPGPDG PELEERPGDR AEEGAVACAA CPGPSPPRPA GTPAAQGDSG
NELLKHLLKN KKASSLLNQK PEGSFCSEDD GTKDNKLVER QNPADVQTLG AQVQGGFGCG
NSQLPKTDGG SETKKQRSKR TQRTGEKAAP RSKKRKKEEE EKQAMFSTTD TFTHLKQQLS
LLPLMEPVIG VNFAHFLPYG SGQFNSGNRL LGTFGSATLE GVSDYYSQLI YKQNNLSNPP
TPPASLPPTP PPMACPKMAN GFATTEELAG KAGVLVSHEV TKSLGPKPFH LPFRPHDDLL
ARAIAQGPKT VDVPASLPTP PHNNQEELRI QDHGGDRDTP DSVVPSSSPE SVVGVEVRRY
PDLSLVKEEP PEPVPSPVIP LLPSSAGKGL ESRRNDIKTE PGTLFFTSPF GSSPNGPRSG
LISVAITLHP TAAENISSVV AAFSDLLHVR IPNSYEVSNA PDVPSVGLVS SHRVNPGLEY
RQRLFLRGPP PGSANPPRLA SSYHLKQPTV PFPPASNGLS GCTGTSHGVT ESAALRPQWC
CHCHVVVLGH GVRKPARDAA FVSKGSRDSS SRAEKDIVFC SNNCFILYSS AAQAKTSESK
ESVPSLPHSP IKETPCRAFH QYSNNISTLD VHCLPQLQEK ASPPASPPIT FPPAFEAAKV
EAKPDELKVT VKLKPRLRTV HGGFEDCRPI TKKWRGMKWK KWSIHVVIPK GTFRPPCEDE
IDEFLKKLGT SLKPDPVPKD YRKCCFCHEE GDGLTDGPAR LLNLDLDLWV HLNCALWSTE
VYETQAGALI NVELALRRGL QMKCVFCHKM GATSGCHRFR CTNIYHFTCA IKAQCMFFKD
KTMLCPMHKP KGIHEQELSY FAVFRRVYVQ RDEVRQIASI VQRGERDHTF RVGSLIFHTI
GQLLPQQMQA FHSPKALFPV GYEASRLYWS TRYANRRCRY LCSIEEKDGR PMFVIRIVEQ
GHEDLVLSDT SPKGVWDKIL EPVARVRKES EMLQLFPAYL KGEDLFGLTV SAVARIAESL
PGVEACENYT FRYGRNPLME LPLAANPTGC ARSEPKMSAH VKRFVLRPHT LNSTSASKSF
QSTVTGELSA PYSKQFVHSK SSQYRKMKTE WKSNVYLARS RIQGLGLYAA RDIEKHTMVI
EYIGTIIRNE VANRKEKLYE SQNRGVYMFR MDNDHVIDAT LTGGPARYIN HSCAPNCVAE
VVTFERGHKI IISSSRRIQK GEELCYDYKF DFEDDQHKIP CHCGAVNCRK WMN
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