ID A0A455B9G1_PHYMC Unreviewed; 662 AA.
AC A0A455B9G1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Zinc finger protein 746 isoform X2 {ECO:0000313|RefSeq:XP_028345412.1};
GN Name=ZNF746 {ECO:0000313|RefSeq:XP_028345412.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028345412.1};
RN [1] {ECO:0000313|RefSeq:XP_028345412.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028345412.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_028345412.1; XM_028489611.2.
DR AlphaFoldDB; A0A455B9G1; -.
DR Proteomes; UP000248484; Chromosome 5.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF145; ZINC FINGER PROTEIN 746-RELATED; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 129..200
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 486..506
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 528..555
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 556..583
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 584..612
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 189..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..632
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 662 AA; 71728 MW; EB19B5200494DB46 CRC64;
MVKQSRKRCV HLPGLCCCDL SWAFREGLDF IRLSWTRGAF QISPWTMAAT IQAMERKIES
QAARLLSLEG RTGMAEKKLA DCEKTAVELG NQLEGKWAVL GTLLQEYGLL QRRLENVENL
LRNRNFWVLR LPPGSKGEAP KEWGKLDECQ RELYKHVMRG NYETLVSLDY AISKPEVLSQ
IEQGKEACSW RRAGPKVPDV PVDPSPGSGP PVPAPDLLMQ IKQEGELQLQ EQQALGVEAW
AAGQPDIGEE PWGLGQLDAG AGDVSTDAAS GVHSNFSSTI PPTSWQADLP PHHPSSACSD
GTLKLSTAAS TEDVKIVIKT EVQEEEVVAT PVHPTDLEAH ATLFGPGQAT RFFPSPVQEG
AWESQGSSFP SQDPVLGLRE PTRPERELGE PSPAVTQDET PPGDWLFGGV RWGWNFRCKP
PAGLNPRTGP EGLPYSSPDN GEAVLDPGQA PRPFSDPCKY PGRTKGFGHK PGLKKHPAAP
PGGRPFTCAA CGKSFQLQVS LSAHQRSCGG LPDGAPGAAG GARDGSGLRC GECGRCFTRP
AHLIRHRMLH TGERPFPCTE CEKRFTERSK LIDHYRTHTG VRPFTCTVCG KSFIRKDHLR
KHQRNHAAGA KPARGQPLPP LPAAPPDPFK SPASKGPLAS TDLVTDWTCG LSVLGPTDGG
DL
//
