ID   A0A455B9X9_PHYMC        Unreviewed;       176 AA.
AC   A0A455B9X9;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Suppressor of IKBKE 1 {ECO:0000256|ARBA:ARBA00041003};
DE   AltName: Full=Suppressor of IKK-epsilon {ECO:0000256|ARBA:ARBA00042344};
GN   Name=SIKE1 {ECO:0000313|RefSeq:XP_028344768.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028344768.1};
RN   [1] {ECO:0000313|RefSeq:XP_028344768.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028344768.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Physiological suppressor of IKK-epsilon and TBK1 that plays
CC       an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-
CC       mediated activation of interferon-stimulated response elements (ISRE)
CC       and the IFN-beta promoter. May act by disrupting the interactions of
CC       IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-
CC       kappa-B activation pathways. {ECO:0000256|ARBA:ARBA00037749}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the SIKE family.
CC       {ECO:0000256|ARBA:ARBA00005537}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_028344768.1; XM_028488967.2.
DR   AlphaFoldDB; A0A455B9X9; -.
DR   Proteomes; UP000248484; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008555; SIKE.
DR   PANTHER; PTHR12186; SIKE FAMILY MEMBER; 1.
DR   PANTHER; PTHR12186:SF4; SUPPRESSOR OF IKBKE 1; 1.
DR   Pfam; PF05769; SIKE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484}.
SQ   SEQUENCE   176 AA;  20247 MW;  3244D304E73D7EF2 CRC64;
     MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGTAL PDQYQEDASD
     IKDMSKYKPH ILLSQENTQI RDLQQENREL WVSLEEHQDA LELIMSKYRK QMLQLMVAKK
     AVDAEPVLKA HQSHSAEIES QIDRICEMGE VMRKAVQMDD DQFCKIQEKL AQLEDI
//