ID A0A455BBV4_PHYMC Unreviewed; 2125 AA.
AC A0A455BBV4;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRB {ECO:0000313|RefSeq:XP_028346194.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028346194.1};
RN [1] {ECO:0000313|RefSeq:XP_028346194.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028346194.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR RefSeq; XP_028346194.1; XM_028490393.2.
DR Proteomes; UP000248484; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 13.
DR CDD; cd14617; R-PTPc-B; 1.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 14.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF2; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA; 1.
DR Pfam; PF00041; fn3; 14.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 16.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 15.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50853; FN3; 9.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_028346194.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1744..1770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 329..421
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 597..686
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 770..861
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 862..948
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 949..1036
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1037..1133
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1215..1303
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1388..1484
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1485..1576
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1831..2091
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 2006..2082
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 159..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2125 AA; 238244 MW; 6D951A29139E11C0 CRC64;
MEAEFYVAIL TCFIFGNSEG FQIVHVQKQQ CLFKNERVVM DLCNGTSQNQ QWMWTEDGKL
LHVKSALCLG ISDSSGGPSR SAIFAPCSRA PRWTCYEKEG FLEVENASLF LKKQGFRVVV
KKGRKYLHSW MKIDVNEEGK PVNESLCSKK AGLGAEVSVR STRNTTPPQI PTTFNALPRS
PGHLISNTTE TFTRSITENY SQNSSQRQHP NLQMAGTTSW VPWTTQPFSS TTEETGLGEP
VRCNFTLTES RVSSRSVSLQ WRTLASPCNF SLICSSDTSG VACCHPVRID NTTYGCNPKD
LQAGTIYNFT IMSLDGEEKT VVLQTDPLPP ARFEVNKEKS TSTSLHVWWT PSSGKVTWYE
VQLLDDNQKT QGAQIQERTS RNEYTFFNLT AGSKYKIAIT AVSGDKRSST IYANGSTVPS
PVKDIGISAK TNSLLISWSR GSGNVERYQL ILMDKGILVH SYAVDKSTTS YAFHGLIPGH
LYNVTIVTEA AGLQNYRWKP ARTIPEKVGD LEANSNGSTR SLVVSWSPPA GDWEQYRILL
LNDSLVLLNT TVGKEETHYV IGDVGLIPGR QYEVEVTVES GNLKNSKRCH GRTVPLAVLQ
LRVKHANETS LGVMWQTPAA EWEKYIISLI DRDLLLIHKL LPKDAKEFTF TDLVPGRKYI
ATVSSISGDL KNSSSTKGRT VPAQVTGLHV ANQGTTSSLF TNWTQALGDI DFYQVLLIHE
NVVIKNESVS SETSRYSFHS LKSGSLYSMV VTTVSGGISS RQVVMEGRTV PSSVSGVRVN
NSGRNDYLSI SWLPAPGDVD NYVVTLSHDG RVVQSLMIAK SVSECSFSSL TPGRLYNVTI
TTRSGKYENH SFGQERTVPD KVQGVSISNS ARSDYLKVSW VHATGDFDHY EVTIKNKNNF
IQTKSIPKSE NECIFVKLVP GRLYSVTVTT KSGQYEASEQ GNGRTIPEAV KDLTLRNRST
EDLQVTWTRA DGDVDQYEIQ LLFNDMKVFP PFHLVNTATE YRFTSLTPGR QYKILVLTIS
GDVQQSAFIE GFTVPSVVKN IHVSPNGATD SLTVNWTPGG GDVDSYAVSA FRQNQKVESQ
TVPKLVSEHT FHRLEAGEQY RIVITSVSGS QKNQVDALGR TVPASVQGIT ADNAYSSHSL
IVSWQKAVGV AERYDILLLS ENGILLSNTS EAATTKQHKF EDLTPGKKYK IQILTVSGGL
FSKEAQTEGR TVPAAVTNLR ITENATRHLS FSWTPSEGEL NWYNIFLYNP DRTLQERAQV
GPQVQSFSFQ NLLQGRMYKM VIVTHSGELS NESSIFGRTV PASVSNLKGS NRNMTDSLWF
SWSPASGDFD FYELILYNPN GTKKENWKDK ELTEWRFHGL VPGRKYTLCV ITHSGDLSNK
VTAESRTAPS PPSLMSFADV ANTSLAITWK GPPDWTDYDD FELQWFPRDA VTVFNPYSNR
KSEGRIVYGL RPGRSYQFSV KTVSGDSWKT YSKPIFGSVR TKPDKIQNLH CRPQNSTAIA
CSWIPPDSDF DGYSIECRKM DTQEVEFSRK LEKEKSLLNI MMLVPHKRYL VSIKVQSAGM
SSEVVEDSTI TMIDRPPPPP PHIRVNKKDV LISKSSINFT FNCSWFSDTN GAVKYFTVVV
READGSDELK PEQQHPLPSY LEYRHNASIR VYQTDYFASK CAESPDSNSK SFNIKLGAEM
ESLGGKCDPN QQKFCDGPLK PRTAYRISIR AFTQLFDEDL KEFTKPLYSD TFFSLPITTE
SEPLFGVIEG VSAGLFLIGM LVAVVALLIC RQKASHGRER PSARLSIRRD RPLSVHLNLG
QKGNRKTSCP IKVNQFEGHF MKLQADSNYL LSKEYEDLKD VGRNQSCDIA LLPENRGKNR
YNNILPYDAS RVKLSNVDDD PCSDYINASY IPGNNFRREY IATQGPLPGT KDDFWKMAWE
QNVHNIVMVT QCVEKGRVKC DHYWPADQDS LYYGDLILQM LSESVLPEWT IREFRICSEE
QLDAHRLIRH FHYTVWPDHG VPETTQSLIQ FVRTVRDYIN RTPGAGPTAV HCSAGVGRTG
TFIALDRILQ QLDSKDSVDI YGAVHDLRLH RVHMVQTECQ YVYLHQCVRD VLRARKLRSE
QENPLFPIYE NVNPEYHRDA GYSRH
//
