ID A0A455BDI5_PHYMC Unreviewed; 989 AA.
AC A0A455BDI5;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Integrin alpha-7 isoform X2 {ECO:0000313|RefSeq:XP_028347040.1};
GN Name=ITGA7 {ECO:0000313|RefSeq:XP_028347040.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028347040.1};
RN [1] {ECO:0000313|RefSeq:XP_028347040.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028347040.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_028347040.1; XM_028491239.2.
DR AlphaFoldDB; A0A455BDI5; -.
DR Proteomes; UP000248484; Chromosome 6.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF90; INTEGRIN ALPHA-7; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 898..920
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 166..227
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 228..283
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 287..346
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 331..495
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 497..661
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 667..885
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 21..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..782
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 989 AA; 107684 MW; 4053619341412062 CRC64;
MWPSTPTCSL PWSPGALPRF SPQPCQHAHE RGHRLSSAWP RAPQHAGMSS PMPSRGPHAP
THQPTPHHSH SHLRTLPLAG LTLGLLFVTN IDSSDPDQLV YKTLDPADRL PGPAGDLALN
SYLGFSIDSG KSLVRAEELS FVAGAPRANH KGAVVILRKD SASRLVPEVT LSGERLTSGF
GYSLAVADLN NDGWTDLVVG APYFFERQEE LGGAVYVYMN QGGHWAGVSP LRLCGSPDSM
FGISLAVLGD LNQDGFPDLA VGAPFAGDGK VFIYHGSSLG VVVKPSQVLE GEAVGIKSFG
YSLSGGLDVD GNRYPDLLVG SLADTAVLFR ARPVLHVSHE VSILPRTIDL EQPNCASGHS
VCMDLRVCFS YIASPSSYSP VVALDYTLDG DTDRRLRGQV PRVTFLSRGP DDPKHQASGT
VWLRRQHDRV CGDTMLQLQE NVKDKLRAIV VTLSYSLQTP RLRRQAPGQG LPPVAPILNA
HQPSTQRTEI HFLKQGCGED KVCQSNLRLV HARFCARVSD TEFQPLPMDA DGTTALFALS
GQPVIGLELK VTNLPSDPAQ PQADGDDAHE AQLLVTLPAS LHYSGVRALD PAEKPLCLSN
ENASHVECEL GNPMKRGAQV TFYLILSTSG ITIETTELAV ELLLATISEQ ELQPVSARAR
VFIELPLSIT GVAIPQQLFF SGVVRGESAM QSERDVGSKV KYEVTVSNQG QSLNTLGSAF
LNIMWPHEIA NGKWLLYPMR VELEGGRGPG QRGLCSPRPN ILHLDVDSRD RRRRELGQPE
PQEPHEQPEP STSWWPVSSA EKKKNVTLDC TRGTASCVVF SCPLYSFDRA AVLHVWGRLW
NSTFLEEYSA VKSLEVIVQA NITVKSSIKN LLLRDASTVI PVMVYLDPAA VVAEGVPWWV
ILLAVLAGLL ALALLVLLMW KMGFFKRARY PEATVPQYHA VKIPREDRQQ FKEEKTGTIL
RNNWGSPRRE GPDAHPILAG DGHPVPGTA
//
