ID A0A455BED5_PHYMC Unreviewed; 1204 AA.
AC A0A455BED5;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Apoptotic protease-activating factor 1 isoform X4 {ECO:0000313|RefSeq:XP_028346278.1};
GN Name=APAF1 {ECO:0000313|RefSeq:XP_028346278.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028346278.1};
RN [1] {ECO:0000313|RefSeq:XP_028346278.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028346278.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_028346278.1; XM_028490477.1.
DR AlphaFoldDB; A0A455BED5; -.
DR Ensembl; ENSPCTT00005011753; ENSPCTP00005010613; ENSPCTG00005007208.
DR Proteomes; UP000248484; Chromosome 6.
DR GO; GO:0043293; C:apoptosome; IEA:InterPro.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0097190; P:apoptotic signaling pathway; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08323; CARD_APAF1; 1.
DR CDD; cd00200; WD40; 2.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR017251; Apaf-1.
DR InterPro; IPR041452; APAF1_C.
DR InterPro; IPR037963; APAF1_CARD_dom.
DR InterPro; IPR048975; APAF1_WHD.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR Pfam; PF21296; APAF-1-like_WHD; 1.
DR Pfam; PF17908; APAF1_C; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF00400; WD40; 10.
DR PIRSF; PIRSF037646; Apop_pept_activating-1; 2.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 13.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 9.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW ATP-binding {ECO:0000256|PIRSR:PIRSR037646-50};
KW Hydrolase {ECO:0000313|RefSeq:XP_028346278.1};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR037646-50};
KW Protease {ECO:0000313|RefSeq:XP_028346278.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 1..90
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REPEAT 566..607
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 608..649
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 650..693
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 694..735
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 833..865
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 954..995
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 995..1035
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1036..1070
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1078..1119
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT BINDING 153..160
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR037646-50"
FT BINDING 264
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR037646-50"
SQ SEQUENCE 1204 AA; 137131 MW; CA9DBD2805CDC56C CRC64;
MDAKARNCLL QHREALERDI KTSYIMDHMI SNGVLTVSEE EKVKNEPTQR QRAAMLIKTI
LEKDNYSYIS FYNALLHEGY KDLADLLHGG IPVISSSSSK DSVGITSYVR TVLCEGGVPQ
RPVVFVTRRK LVNAIQQKLF KLRGEPGWVT IYGMAGCGKS VLAAEAVRDH SVLEVCFPGG
VHWVSVGKQD KSGLLMKLQN LCTRLDQDEN FSQRLPLNIE EAKDRLRILM LRKHPRSLLI
LDDVWDPWVL KAFDNQCQIL LTTRDKSVTD SVMGSPLVVS LIGALLRDFP NRWEYYLRQL
QNKQFKKIRK SSFYDYEALD EAMSVSVEML REDIKDYYTD LSILQKDVKV PTKVLCILWD
METEEVEDIL QEFVNKSLLF CDRNGKSFLY YLHDLQVDFL TEKNHSQLQD LHKKLITQFQ
RHFRLHCLSP DQEDCMYWYN FLAYHMASAK MHKELCALMF SLDWIKAKTE LVGPAHLIHE
FVEYRHMLDE KDGTVCENFQ EFLSLNGHLL GRQPFPNIVQ LGLCELETSE VYQQAKLKAK
QEVDNGMLYV EWINKENIKN LSRLVVRPHT DAVYHACFSE DGQRIASCGA DKNLQVFKAE
TGEKLLEIKA HEDEVLCCAF SADDRFIATC SVDKKVKIWN SMSGELVHTY DEHSEQVNCC
HFTNNSNHLL LATGSNDCFL KLWALNQKEC RNTMFGHTNS VGHCRFSPDD KLLASCSADG
TLKLWDVKSA NESKSINVKQ FFLNSEEPQE DMEVIVKCCS WSADGARIMV AAKNKVFLFD
IHTSGLLAEI HTGHHSTVQY CDFSPHNHLA VVALPQYCVE LWNMDSCLKV ADCRGHLSWV
HCVMFSPDGS SFLTSSDDQT IRLWETKKVC KNSAIVLKQE IDVVFQENEV MVLAVDDIKR
LQLINGTTGQ IDYLTEAHVS CCCLSPHLQY LAFGGEDGAI RILELLNNRI FQSRTGHKNT
VRHIQFTADA KTLISSSDDS AIQVWNWQSE EYVFLQAHQE TVKDFRLLKN SRLLSWSFDG
TVKVWNIITG RIEKDFVCHQ DTVLSCDISP DETKYSSTSA DKTAKIWSFE LLSPLHELRG
HKGCVRCSAF SVDSTLLATG DDNGEIRIWN VSDGELLHLF APISVEEGAA THGGWVTDLC
FSPDSTMLVS AGGYLKWWNV VTGESSQTFY TNGTNLKKIH VSPDFKTYVT VDNLGILYIL
KILE
//
