ID A0A455BFV5_PHYMC Unreviewed; 1261 AA.
AC A0A455BFV5;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=AF4/FMR2 family member 1 isoform X3 {ECO:0000313|RefSeq:XP_028347679.1};
GN Name=AFF1 {ECO:0000313|RefSeq:XP_028347679.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028347679.1};
RN [1] {ECO:0000313|RefSeq:XP_028347679.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028347679.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR RefSeq; XP_028347679.1; XM_028491878.2.
DR AlphaFoldDB; A0A455BFV5; -.
DR Proteomes; UP000248484; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF6; AF4_FMR2 FAMILY MEMBER 1; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 998..1260
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 28..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..298
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..880
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..973
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1160..1177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1261 AA; 136688 MW; 79A6893DCA361B46 CRC64;
MAFTERVNSS GNSSLYNEDR NLLRIREKER RNQEAHQEKE AFSEKIPLFG EPYKTEKGDE
LSSRIQNMLG NYEEVKEFLN TKSHPQRLDA SENRLGKPRY PSFPEKGSSI PSHSFHTSVH
HQPINTPASG PLPIGTISHN PKMAQPRMEP MPSLHVKSYG PPDSQHMTQD RLGQEGYSSS
HHKKGDRRAD GDHCASMTDS APERELSPLF SLPSPVPPLS PVHSNQQTLP RTQGSNKVHS
SNSNNKGYCP AKSPKDLPVK VHDKETLQDS SVAVASLAVA PPQPPSQTFP PPPLPSKSLA
MQQKPTAYVR PMDGQDQAPS ESPELKPLPE DYRQQSFEKT DLKVPAKAKL TKLKMPSQSV
EGFCRYQKQW NMDSYAPCHQ VEMRSTYSSE VHCVEEILKE MTHSWPPPLT AIHTPSTAEP
SKFPFPAKDS QHISSATLNQ KQYDTSSKTH SNSQQGTSVS IPACSSMLKD DLQLSDSEDS
DSDQTPEKPP PASAPPSAPQ ALPAAAASAH SSSAESESTS DSDSSSDSES ESSSSDSEEN
EPRETPAPEP EPPTTNKWQL DNWLTKVSQP APPAEAPGSA EPPARHPDSK GKGGDGATGG
HERSESKEPP PKSSSKAPRL PSEGPHAGKR SSQKSPAQQE PPQRQTVGSK QPKKPVKASA
PGHADAHADA RASLLVESEP GLPPQASKDQ PSKDKPKVKT KGRPRAAESR EPKPVAPTPS
ERKKHRSGPP APPKAPPKDA AGDRSPEHFA LVPLTQSQGP ARSGGARTSG CRLAVVVQED
RRKDKPLVPL RDTKLLSPLR DTPLPQSLMV KITLDLLSRI PQPPGKGSRP KKPEDKQPSA
AKKADSEKRS SENSSKLAKK RKGEAERDHD SKKIRLEKEV KSQSSPSSSH KESSKSKTPK
PSSEPSKKEM LPPSLVSSSS ASSQKPAKPA QKRSRQEADP SGQDPPKSAS STKGNHRDSS
VSKHRKVEGK GSGSSAEHKG SSGDTANRFP VPSLPNGNSK PGKPHMKLDK QQADFHMKEA
KRLKDKAELV TDKVGKAFKY LEAALSFIEC GIAMELESPA SKSACSIYAE TLDLIKFIMS
LKSFSDATTP TQEKIFAVLC MRCQSILNMA MFRCKKDIAI KYSRTLNEHF FKTSSKVAQA
PSPCIARSTG TPSPLSPMPS PASSIGSQSS AGSVGSGGMP ATISTPVTIQ NMTSSYVTIT
SHVLTAFDLW EQAEVLTRKN KEFFAQLGTG VCALALDSSL MDLVRYTRQG FQRLKQVTKT
P
//
