ID A0A455BG10_PHYMC Unreviewed; 990 AA.
AC A0A455BG10;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Guanylate cyclase {ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|RuleBase:RU003431};
GN Name=GUCY2C {ECO:0000313|RefSeq:XP_028346848.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028346848.1};
RN [1] {ECO:0000313|RefSeq:XP_028346848.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028346848.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00036920};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13666;
CC Evidence={ECO:0000256|ARBA:ARBA00036920};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR RefSeq; XP_028346848.1; XM_028491047.2.
DR AlphaFoldDB; A0A455BG10; -.
DR Proteomes; UP000248484; Chromosome 6.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06369; PBP1_GC_C_enterotoxin_receptor; 1.
DR CDD; cd14044; PK_GC-C; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR042822; GC-C_PK.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF347; GUANYLYL CYCLASE C; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..990
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019789746"
FT TRANSMEM 431..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 489..749
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 824..954
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 990 AA; 113754 MW; 8F6373A9E69E664B CRC64;
MKTPLLALAL WSLLLRPGLL FWTSHMSQNC HNGSYKISVL MMNNSAFPES RVNLEEVVNA
GLEIVRQRLL QAGLNVTVNA TFIYSEGMIY KSSDCRSSTC EGLELLRMIS RDKQMGCVLM
GPTCTYSTFQ IYLDTDLNYP MISAGSFGLS CDYKETLTRL MSPARKLMYF LVDFWKVNYF
PFKTSSWNTA YVFKNGTESE DCFWYLNALE AGVSYFSQKL SFKEMLRGDN EFQRILLDQN
RKSNVIVMCG TPNTINVLKG DRAVAEDTVI ILVDLFNEYY FMDNVTAPDY MKNVLVLTLP
PGNSVSNSSF AKNLSLAKND FAAAYFDGVL LFGHMLKIFL ENGEEVTTPK FAHAFRNVTF
EGHVGPVTLD DCGDIDNTMF LLYTSVDTNK YKVLLTYDTR INQTNPVDKS PTFIWKNHKL
PNDIPGRGPQ ILMVAVFTLT GAVVLVLLIA LLVLRKYKGE YALRQKKWSH IPPENIFPLE
SNETNHVSLK IDDDKRRDTI QRLRQCKYDK KRVILKDLKH NDGNFTEKQK IELNKLLQID
YYNLTKFYGT VKLDSMIFGV IEYCERGSLR EVLNDTISYP DGTFMDWEFK ISVLYDIAKG
MSYLHSSKTE VHGRLKSTNC VVDSRMVVKI TDFGCNSILP PRKDLWTAPE HLRQANISQK
GDVYSYGIIA QEIILRRETF YTLSCRDQKE KIFRVENSNG VKPFRPDLFL ETAEEKELEV
YLLVKNCWEE DPEKRPDFKK IENTLAKIFG LFHDQKNETY MDTLIRRLQL YSRNLEHLVE
ERTQLYKAER DRADRLNFML LPRLVVKSLK EKGIVEPELY EEVTIYFSDI VGFTTICKYS
TPMEVVDMLN DIYKNFDHIL DHHDVYKVET IGDAYMVASG LPKRNGNRHA IDIAKMALDI
LSFMGTFELE HLPGLPIWIR IGIHSGPCAA GVVGIKMPRY CLFGDTVNTA SRMESTGLPL
RIHVSGSTIS ILKRTECQFL YEVRGETYLK
//
