ID   A0A455BH14_PHYMC        Unreviewed;       890 AA.
AC   A0A455BH14;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO6 {ECO:0000313|RefSeq:XP_028347203.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028347203.1};
RN   [1] {ECO:0000313|RefSeq:XP_028347203.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028347203.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   RefSeq; XP_028347203.1; XM_028491402.1.
DR   AlphaFoldDB; A0A455BH14; -.
DR   Proteomes; UP000248484; Chromosome 6.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF21; ANOCTAMIN-6; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        278..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        439..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        486..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        534..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        650..673
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        701..725
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        805..826
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          41..264
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          267..850
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   890 AA;  103948 MW;  415714D6826B673B CRC64;
     MSTFLENLEQ TIVSGFGSLE SQQDFRTPEF EEFNGKPDSL FFSDGQRRID FVLVYEDESR
     KETNKKGSNE KQRRKRRAYE SNLICDGLQL EATRSLLDDK LVFVKVHAPW EVLCTYAEIM
     HIKLPLKPND LKTRSSAFDN FNWFTKVLQV DESIIKPEQE FFTAPFEKNR MNDFYIQDRD
     TFFNPATRSR IVYFILSRIK YQVRDNVKKF GINKLVSSGI YKAAFPLHDC SFSSPSEDLS
     CPNERYLLYR EWAHPRSIYK KQPLDLIRKY YGEKIGIYFA WLGYYTQMLL LAAVVGVACF
     LYGYFNQNNC TWSKEVCDPD IGGKIIMCPQ CDKLCPFWKL NITCESSKKL CLFDSFGTLV
     FAVFMGVWVT LFLEFWKRRQ AELEYEWDTV ELQQEEQARP EYEARCTHVV INEITQEEER
     IPFTTWGKCI RITLCASAVF FWILLIIASV IGIIVYRLSV FIVFSAKLPK NLNGTDPIQK
     YLTPQMATSI TASLISFIII MILNTIYEKV AIMITNFELP RTQTDYENSL TMKMFLFQFV
     NYYSSCFYIA FFKGKFVGYP GDPVYWLGKY RNEECDPGGC LLELTTQLII IMGGKAIWNN
     IQEVLLPWVM NLIGRCRTVS GAEKKTPRWE QDYHLQPMGK LGLFYEYLEM IIQFGFVTLF
     VASFPLAPLL ALVNNILEIR VDAWKLTTQY RRMVPEKAQD IGAWQPIMQG IAILAVVTNA
     MIIAFTSDMI PRLVYYWSFS IPPYGDHPHY TMEGYINNTL SYFNVADFKS KSKENPYTEL
     GDYTACRYRD FRYPPGHPQE YKHNIYYWHV IAAKLAFIIV MEHIIYSVKF FISYAIPDVS
     KSTKSKIRRE KYLTQKLLHE NHLKDMTKNM GVIAERMIAV VDNNLRPKSD
//