ID   A0A455BH32_PHYMC        Unreviewed;       953 AA.
AC   A0A455BH32;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Short transient receptor potential channel 3 isoform X1 {ECO:0000313|RefSeq:XP_028348047.1};
GN   Name=TRPC3 {ECO:0000313|RefSeq:XP_028348047.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028348047.1};
RN   [1] {ECO:0000313|RefSeq:XP_028348047.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028348047.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; XP_028348047.1; XM_028492246.2.
DR   AlphaFoldDB; A0A455BH32; -.
DR   InParanoid; A0A455BH32; -.
DR   OrthoDB; 5406916at2759; -.
DR   Proteomes; UP000248484; Chromosome 7.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005459; TRPC3_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   NCBIfam; TIGR00870; trp; 1.
DR   PANTHER; PTHR10117:SF8; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; 1.
DR   PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01644; TRPCHANNEL3.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM01420; TRP_2; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_028348047.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        418..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        454..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        505..522
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        543..564
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        652..672
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        692..708
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        720..742
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          266..328
FT                   /note="Transient receptor ion channel"
FT                   /evidence="ECO:0000259|SMART:SM01420"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          66..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   953 AA;  109535 MW;  C25D63F4D9624349 CRC64;
     MSTKVSKCKE QARVTFPAPE EEEEGEDEGA EPQRRRRGWR GVNGGLEPRL APWQREPRDY
     CLPPFPPGPD MSMEESPSLR RKTVMREKGR RQAVRGPAFM FNDRGTSLTA EEERFLDAAE
     YGNIPVVRKM LEESRTLNVN CVDYMGQNAL QLAVGNEHLE VTELLLKKEN LARIGDALLL
     AISKGYVRIV EAILNHPGFA ASKRLTLSPC EQELRDDDFY AYDEDGTRFS PDITPIILAA
     HCQKYEVVHM LLLKGARIER PHDYFCKCGD CAEKQRHDSF SHSRSRINAY KGLASPAYLS
     LSSEDPVLTA LELSNELAKL ANIEKEFKND YRKLSMQCKD FVVGVLDLCR DSEEVEAILN
     GDLESAEPLE MHRHKASLSR VKLAIKYEVK KFVAHPNCQQ QLLTIWYENL SGLREQTIAI
     KCLVVLVVAL GLPFLAIGYW IAPCSRLGKI LRSPFMKFVA HAASFIIFLG LLVFNASDRF
     EGITTLPNIT VIDYPKQIFR VKTTQFTWTE MLIMVWVLGM MWSECKELWL EGPREYILQL
     WNVLDFGMLS IFIAAFTARF LAFLQATKAQ QYVDSYVQES DLSEVTLPPE IQYFTYARDK
     WLPSDPQIIS EGLYAIAVVL SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVLFIMVF
     LAFMIGMFIL YSYYLGAKVN AAFTTVEESF KTLFWSIFGL SEVTSVVLKY DHKFIENIGY
     VLYGIYNVTM VVVLLNMLIA MINSSYQEIE DDSDVEWKFA RSKLWLSYFD DGKTLPPPFS
     LVPSPKSFVY FIMRIINFSK CRRRRLQKDI EMGMGNSKSR LNLFTQSNSR VFESHSFNSI
     LNQPTRYQVV RLQIYSPWLQ GSLHWSGRAA RRWRGREGKK KQIMKRLIKR YVLKAQVDKE
     NDEVNEGELK EIKQDISSLR YELLEDKSQA TEELAILIHK LSEKLNPSVL RCE
//