ID A0A455BHF6_PHYMC Unreviewed; 493 AA.
AC A0A455BHF6;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN Name=LOC102986434 {ECO:0000313|RefSeq:XP_028347338.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028347338.1};
RN [1] {ECO:0000313|RefSeq:XP_028347338.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028347338.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005093}.
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family. NDST subfamily.
CC {ECO:0000256|ARBA:ARBA00010420}.
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DR RefSeq; XP_028347338.1; XM_028491537.1.
DR AlphaFoldDB; A0A455BHF6; -.
DR STRING; 9755.ENSPCTP00005008818; -.
DR KEGG; pcad:102986434; -.
DR InParanoid; A0A455BHF6; -.
DR OrthoDB; 2913264at2759; -.
DR UniPathway; UPA00756; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000248484; Chromosome 7.
DR GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0019213; F:deacetylase activity; IEA:UniProt.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR021930; Heparan_SO4_deacetylase.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF45; BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE 4; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF12062; HSNSD; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Transferase {ECO:0000256|RuleBase:RU361155}.
FT DOMAIN 1..126
FT /note="Heparan sulphate-N-deacetylase"
FT /evidence="ECO:0000259|Pfam:PF12062"
FT DOMAIN 216..465
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 225
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 323
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 428
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 444..448
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 429..439
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 493 AA; 57460 MW; 2B84F725D8D0CD90 CRC64;
MWSHMQPHLF HNESSLVEQM ILNKEFALEH GIPINMGYAV APHHSGVYPV HIQLYAAWKK
VWGIQVTSTE EYPHLKPARY RKGFIHDSIM VLPRQTCGLF THTIFYKEYP GGPQELDKSI
RGGELFLTIL LNPISIFMTH LSNYGNDRLG LYTFVNLANF AQSWTNLKLR TLPPVQLAHK
YFELFPEQKD PLWQNPCDDK RHKDIWSREK TCDHLPKFLV IGPQKTGTTA LYLFLLMHPS
IISNLPSPKT FEEVQFFNGN NYHKGIDWYM EFFPTPSNIT SDFLFEKSAN YFHSEEAPKR
AASLVPKAKI ITILIDPSDR AYSWYQHQRS HEDPAALRFN FYEVITTAHW APSDLKTLQR
RCLLPGWYAV HIERWLTYFA TSQLLIIDGQ QLRSDPVTVM DEVQKFLGVT PHYNYSEALT
FDPQKGFWCQ LLEGGKTKCL GKSKGRKYPP MDPESRAFLS DYYRDHNVEL SKLLHRLGQP
LPSWLRQELQ KVR
//
