ID A0A455BIS8_PHYMC Unreviewed; 3477 AA.
AC A0A455BIS8;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=WD repeat and FYVE domain-containing protein 3 isoform X5 {ECO:0000313|RefSeq:XP_028347803.1};
GN Name=WDFY3 {ECO:0000313|RefSeq:XP_028347803.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028347803.1};
RN [1] {ECO:0000313|RefSeq:XP_028347803.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028347803.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_028347803.1; XM_028492002.2.
DR Proteomes; UP000248484; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF1; WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 2522..2647
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2674..2967
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3114..3155
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 3445..3477
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 2472..2513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3265..3326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3265..3280
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3281..3319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3477 AA; 389681 MW; FE2C87252945D462 CRC64;
MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFTELCHPPR HMTQKEQEEK LYMMLPVFNR
VFGNAPPNTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS TEKQCAPLSS KDFKATTPSE
AASRAIVQFL EINQSEEASR GWMLLTTINL LASSGQKTVD CMTTMSVPST LVKCLYLFFD
LPHVPEAVGG AQNELPLAER RGLLQKVFVQ ILVKLCSFVS PAEELAQKDD LQLLFSAITS
WCPPYNLPWR KSAGEVLMTI SRHGLSVNVV KYIHEKECLS TCVQNMQQSD DLSPLEIVEM
FAGLSCFLKD SSDVSQTLLD DFRIWQGYSF LCDLLLRLEQ AKEAESKDAL KDLVNLITSL
TTYGVSELKP AGITTGAPFL LPGFAVPQPA GKGHSVRNVQ AFAVLQNAFL KAKTNFLAHI
ILDAITNIYM ADNANYFILE SQHTLSQFAE KISKLPEVQN KYFEMLEFVV FSLNYIPCKE
LISVSILLKS SSSYHCSIIA MKTLLKFTRH DYIFKDVFRE VGLLEVMVNL LHKYAALLKE
PTQALNEQGD SRNNSSFEDQ KHLALLVMET LTVLLQGSNT NAGIFREFGG ARCAHNIVRY
PQCRQHALMM IQQLVLSPNG DDDMGTLLGL MHSAPPTELQ LKTDILRALL SVLRESHRSR
TVFRKVGGFV YITSLLVAME RSLSSPPKNG WEKVNQNQVF ELLHTVFCTL TAAMRYEPAN
SHFFKTEIQY EKLADAVRFL GCFSDLRKIS PMNVFPSNTQ PFQRLLEEDV ILMDSVSPTL
RHCSKLFIYL YKVATDSFDR HAYHSVSTPP AYPPKNVADL KLHVATSSLQ SSDAVIIHPG
AMLSMLDLLA SVGSVTQPEH ALDLQLAVAN ILQSLVHTER NQQVMCEAGL HARLLQRCSA
ALADEDHSLH PPLQRMFERL ASQALEPMVL REFLRLASPL NCGAWDKKLL KQYRVHKPSS
LSYEPEMRSS VITSMEGLGS DSVFSLHEDN HYRISKSLVK SAEGSTVPLT RVKCLVSMTT
PHDIRLHGSS VTPTFVEFDT SLEGFGCLFL PSLAPHNAPT NNAVTTGLTD GAVVSGIGSG
ERFFPPPSGL SYSSWFCIEH FSSPPNNHPV RLLTIVRRAN SSEQHYVCLA IVLSAKDRSL
IVSTKEELLQ NYVDDFSEES SFYEILPCCA RFRCGELIIE GQWHHLVLVM SKGMLKNSTA
TLYIDGQLVS TVKLHYVHST PGGSGSANPP VVSTVYAYIG TPPAQRQIAS LVWRLGPTHF
VEEVLPPSNV TTIYELGPNY VGSFQAVCMP CKDAKSEGVV PSPVSLVPEE KVSFGLYALS
VSALTVARIR KVYNKLDSKA IAKQLGISSH ENATPVKLIH NSAGHLNGPA RTIGATLIGY
LGVRTFVPKP VATTLQYIGG AAAILGLVAM ASDVEGLYAA VKALVCVVKS NPLASKEMER
IKGYQLLAML LKKKRSLLNS HILHLTFSLV GTVDSGHETS IIPNSTAFQD LLCDFEVWLH
APYELHLSLF EHFIELLTES SEASKNAKLM REFQLIPKLL LTLRDMSLSQ PTIAAISNVL
SFLLQGFPNS NDLLRFGQFI SSTLPTFAVC EKFVVMEINH EEKPDTGTEE EFGGLVSANL
ILLRNRLLDI LLKLVYTSKE KTSINLQACE ELVRTLGFDW IMMFMEEHLH STTVTAAMRI
LVVLLSNQSI LIKFKEGLSG GGWLEQTDSV LTNKIGTVLG FNVGRSAGGR STVREINRDA
CHFPGFPVLQ SFLPKHTNVP ALYFLLMALF LQQPVSELPE NLQVSVPVIS SRCKQGCQFD
LDSIWTFIFG VPASSGTVVS SIHNVCTEAA FLLLGMLRSM LNSPWQSEEE GSWLREYPVT
LMQFFRYLYH NVPDLASMWM SPDFLCALAA TVFPFNIRPY SEMVTDLDDE VGSPAEEFKA
FAADTGMNRS QSEYCNVGVK TYLTNHPAKK FVFDFMRVLI IDNLCLTPAS KQTPLIDLLL
EASPERSTRT QQKEFQTYIL DSVMDHLLAA DVLLGEDASL PITSGGSYQV LVNNVFYFTQ
RVVDKLWQGM FNKESKLLID FIIQLIAQSK RRSQGLSLDA VYHCLNRTIL YQFSRAHKTV
PQQVALLDSL RVLTVNRNLI LGPGNHDQEF ISCLAHCLIN LHVGSNVDGF GLEAEARMTT
WHIMIPSDIE PDGGYSQDIS EGRQLLIKAV NRVWTELIHS KKQTLEELFK VTLPVNERGH
VDIAIAKPLI EEAGLKCWQN HLAHEKKCIS RGEALVPTTQ SKLSRVSSGF GLSKLTGSRR
NRKESGLHKH SLSTQEISQW MFTHIAVVRD LVDTQYKEYQ ERQQNALKYV TEEWCQIEYE
LLRERGLWGP PIGSHLDKWM LEMTEGPCRM RKKMVRNDMF YTHYPYVPET EQETNVASEI
PSKQPETPDD IIPQKKPARY RRAISYDSKE YYMRLASGNP AIVQDAIVES SEGEATQQEP
EHGEDTIAKV KGLVKPPLKR SRSAPDGGDE ETQEQLQDQI AEGSSIEEEE KTDNATLLRL
LEEGEKIQHM YRCARVQGLD TSEGLLLFGK EHFYVIDGFT MTATREIRDI ETLPPNMHEP
IIPRGARQGP SQLKRTCSIF AYEDIKEVHK RRYLLQPIAV EVFSGDGRNY LLAFQKGIRN
KVYQRFLAVV PSLTDSSESV SGQRPNTSVE QGSGLLSTLV GEKSVTQRWE RGEISNFQYL
MHLNTLAGRS YNDLMQYPVF PWILADYDSE EVDLTNPKTF RNLAKPMGAQ TDERLAQYKK
RYKDWEDPNG ETPAYHYGTH YSSAMIVASY LVRMEPFTQI FLRLQGGHFD LADRMFHSVR
EAWYSASKHN MADVKELIPE FFYLPEFLFN SNNFDLGCKQ NGTKLGDVIL PPWAKGDPRE
FIRVHREALE CDYVSAHLHE WIDLIFGYKQ QGPAAVEAVN VFHHLFYEGQ VDIYNINDPL
KETATIGFIN NFGQIPKQLF KKPHPPKRVR SRLNGDNAGI LVPPGSTGDK IFFHHLDNLR
PSLTPVKELK EPVGQIVCTD KGILAVEQNK VLIPPTWNKT FAWGYADLSC RLGTYESDKV
VTVYECLSEW AQILCAICPN PKLVITGGTS TVVCVWEMGA SKEKAKILTL KQALLGHTDT
VTCATASLAY HIIVSGSRDR TCIIWDLNKL SFLTQLRGHR APVSALCINE LTGDIVSCAG
TYIHVWSING SPVVSVNTFT GRSQQIICCC VSEMNEWDTQ NVIVTGHSDG VVRFWRMEFL
QVPETPAPET VEVLEMQEDC PEAQIGPEAQ DEDSSDSEAD EQSVSQDPGD TPSQPSSTSH
RPRAASCRAT ATWCNDSGSD DSRRWSDQLS LDEKDGFVFV NYSEGQTRPH LQAPLNHPHP
NPAEARNFSR LKPGYRWERQ LVFRSKLTMH TAFDRKDNAH PAEITALGVS KDHSRILVGD
SRGRVFSWSV SDQPGRSAAD HWVKDEGGDS CSGCSVRFSL TERRHHCRNC GQLFCQK
//