ID A0A455BJX1_PHYMC Unreviewed; 857 AA.
AC A0A455BJX1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=E3 ubiquitin-protein ligase Jade-2 isoform X1 {ECO:0000313|RefSeq:XP_028349042.1};
GN Name=JADE2 {ECO:0000313|RefSeq:XP_028349042.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028349042.1};
RN [1] {ECO:0000313|RefSeq:XP_028349042.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028349042.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_028349042.1; XM_028493241.2.
DR AlphaFoldDB; A0A455BJX1; -.
DR STRING; 9755.ENSPCTP00005015580; -.
DR InParanoid; A0A455BJX1; -.
DR OrthoDB; 163389at2759; -.
DR Proteomes; UP000248484; Chromosome 8.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15705; ePHD_JADE2; 1.
DR CDD; cd15680; PHD_JADE2; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR039549; JADE2_ePHD.
DR InterPro; IPR039548; JADE2_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793:SF84; E3 UBIQUITIN-PROTEIN LIGASE JADE-2; 1.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR Pfam; PF10513; EPL1; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 227..277
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 279..393
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..748
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..846
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 94768 MW; 4A25C313F98EF413 CRC64;
MLEMAEPQGG RIPVPKLSLG GHTPLIRNTH MEEKRRKYSI SSDNSDTTDS HATSASRCSK
LPSSTKSGWP RQNEKKPSEV FRTDLITAMK IPDSYQLSPD DYYILADPWR QEWEKGVQVP
AGAEAIPEPV VRILPPLEGP PTQVSPSGSE LGEGSQPDWP GGSRYDLDEI DAYWLELINS
ELREMERPEL DELTLERVLE ELETLCHQNM ARAIETQEGL GIEYDEDVVC DVCRSPEGED
GNEMVFCDKC NVCVHQACYG ILKVPTGSWL CRTCALGVQP KCLLCPKRGG ALKPTRSGTK
WVHVSCALWI PEVSIGCPEK MEPITKISHI PASRWALSCS LCKECTGTCI QCSMPSCVTA
FHVTCAFDHS LEMRTILADN DEVKFKSFCQ EHSDGGPQGE TTSEPVEPSP ASEDLEKVTL
RKQRLQQLEE DFYELVEPAE VAERLDLAEA LVDFIYQYWK LKRKANANQP LLTPKTDEVD
NLAQQEQDVL YRRLKLFTHL RQDLERVRNL CYMVTRRERT KHAICKLQEQ IFHLQMKLIE
QDLCRERSGR RAKGKKSDSK RKGREGPKGS PEKKEKVKAG SDSVLGQLGL STSFPIDGTF
FNSWLAQSVQ ITAENMAMSE WSLNNGHRED PAPGLLSEEL LQDEETLLSF MRDPSLRPGD
PARKARGRTR LPAKKKPPQD GPGSRTTPDK TPKKPWGQDA GSGKGGQGPP ARRPPRRTPS
HLPSSPTAED CPIPAAPESP PPLAPETPDE AAPVAADTSV QVPGPTAGPK PSGRLRPPRE
SRGTRRSPSA RPDAGTGPPS AVAERPKVSL HFDTETDGYF SDGEMSDSDV EAEDSGVQRG
PREAGAEEVV RMGVLAS
//