ID A0A455BLC6_PHYMC Unreviewed; 907 AA.
AC A0A455BLC6;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Complement component C7 isoform X1 {ECO:0000313|RefSeq:XP_028348678.1};
GN Name=C7 {ECO:0000313|RefSeq:XP_028348678.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028348678.1};
RN [1] {ECO:0000313|RefSeq:XP_028348678.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028348678.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR RefSeq; XP_028348678.1; XM_028492877.2.
DR AlphaFoldDB; A0A455BLC6; -.
DR STRING; 9755.ENSPCTP00005026556; -.
DR KEGG; pcad:102994066; -.
DR InParanoid; A0A455BLC6; -.
DR OrthoDB; 5303272at2759; -.
DR Proteomes; UP000248484; Chromosome 8.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 3.30.60.30; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR048827; C7_FIM2_N.
DR InterPro; IPR048825; C7_KAZAL.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR040729; Kazal_3.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF2; COMPLEMENT COMPONENT C7; 1.
DR Pfam; PF21284; C7_FIM2_N; 1.
DR Pfam; PF21330; C7_KAZAL; 1.
DR Pfam; PF18434; Kazal_3; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00084; Sushi; 2.
DR PRINTS; PR00764; COMPLEMENTC9.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00057; FIMAC; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50923; SUSHI; 2.
DR PROSITE; PS50092; TSP1; 2.
PE 3: Inferred from homology;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT DOMAIN 187..520
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 633..692
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 693..754
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 177..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 154..172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 663..690
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 907 AA; 100800 MW; 4F005686286FD9F4 CRC64;
MNKLMSACMN EWKNYCGRCW WCPAYILQIL KIPATFYWKS FFSFFPGYRC VLNLPPVQAG
SVRELAISLF FLVGFIGEFQ VFSSATSPVN CQWASYAPWS ECNGCTKTQT RRRSIAVYGQ
YGGHPCVGSA FEPQSCEPTR GCPTEEGCGE RFRCFSGQCI SISLVCNGDS DCEEDGADED
RCEDSESRPS CDLDKPPPNI ELTGHGYNAL TGQFRNKVLN TKSFGGQCRK VFSGDGRDFY
RLSGNSLSYT FQVKINNDFN YEFYNSTWSY VKHTSTEHSS SSEGRRFLFF SSSSSSSSYS
SNIEEIHKEK SYQLLVLQNT VEVAQFINNN PDFLQLSESF WKELSYLPSL YDYSAYRRLI
DQYGTHYLQS GSLGGEYKVI FYMDSEKIKQ SGLSSEEKKK CASSHIKFLF KSSEHKCKEM
EETLKLVSGT QGSVLRGVPF VRGGRPGLVS GLSYLELDNP AGNKWRYSRW AGSVTELPQV
IKQKLTPLYE LVKEVPCASV KRLYLKRAIE EYLDEFDPCH CRPCQNGGMA TVKGTQCQCH
CKPYTFGVAC EQGALVGDQA GGVDGGWSCW SSWGPCVQGK KTRSRECNNP PPSEGGKSCI
GETSETRQCE DQDLEHLRLL EPHCFPLSLV PTEFCPSPPA LKDGYVQDEG AMFPVGKNIV
YTCNEGYSLV GDPVARCGEN LQWLVGKMHC QKIACVLPAL MDGIQSHPHK PFYTIGEKVT
FSCSGGRSLE GPSTFLCGSS LKWSPEMKNV QCVQKDAPLA PEVPECQRWE KLQNSRCVCK
MPYECGSSLD VCARDERSKR ILPLTVCKMH VLQCQGRNYT VAGRESCTLP ASAGKACGVC
PLWGKCDAQS GKCVCRAASE CEETGFSVCV EANGRERTMT ECEAGVLRCR GQSISVTSIR
PCAAEAP
//
