ID A0A455BNK8_PHYMC Unreviewed; 1791 AA.
AC A0A455BNK8;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Afadin isoform X2 {ECO:0000313|RefSeq:XP_028350560.1};
GN Name=AFDN {ECO:0000313|RefSeq:XP_028350560.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028350560.1};
RN [1] {ECO:0000313|RefSeq:XP_028350560.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028350560.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_028350560.1; XM_028494759.2.
DR Proteomes; UP000248484; Chromosome 10.
DR GO; GO:0005911; C:cell-cell junction; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd22711; FHA_AFDN; 1.
DR CDD; cd15471; Myo5p-like_CBD_afadin; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01782; RA1_Afadin; 1.
DR CDD; cd01781; RA2_Afadin; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR InterPro; IPR028842; Afadin.
DR InterPro; IPR037977; CBD_Afadin.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10398; AFADIN; 1.
DR PANTHER; PTHR10398:SF2; AFADIN; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 2.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 2.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 39..134
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 247..349
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 654..894
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT DOMAIN 993..1079
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 130..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1093..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1188..1207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1218..1487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1533..1791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1496..1523
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 144..196
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1233..1247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1260..1286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1372..1408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1414..1435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1579..1647
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1656..1674
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1763..1791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1791 AA; 201342 MW; 24DBDA1028D21222 CRC64;
MSAGGRDEER RKLADIIQHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK AAGNFATKCI
RVSSTATTQD VLETLAEKFR PDMRMLSSPK YSLYEVHVSG EERRLDIDEK PLVVQLNWNK
DDREGRFVLK NENDAIPAKK AQSNGPEKQE KEGVIQNFKR TLSKKEKKEK KKREKEAMRQ
ASDRDDRPFH GDDTENSRLA AEVYKDMPET SFTRTISNPE VVMKRRRQQK LEKRMQEFRS
SDGRPDSGGT LRIYADSLKP NIPYKTILLS TTDPADFAVA EALEKYGLER ENPKDYCIAR
VMLPPGAQHS DEKAAEEIIL DDDECPLQIF REWPNDRGIL VFQLKRRPPD YIPKKSQKHV
DGKPLHGKER VDGSGYGSAL PPEKLPYLVE LSPDGSDSRD KPKLYRLQLS VTEVGTEKFD
DGSIQLFGSG IEPHHCDLTN MDGVVTVTPR SMDAETYVDG QRISETTMLH SGMKVQFGAS
HVFKFVDPSQ DHALPKRSVD GGLMAKGPRQ RPGIVQETTF DLGGDVHSGT ALPASKSSSR
LDGDRGLSAA STAERGMVKP VVRVEQLPDY RRQESRTQDT PGPDLILPAS IEFRESSEDS
FLSAIINYTN SSTVHFKLSP TYVLYMACRY VLSSQYRPDV SPAERTHKVI AIVNKMVSMM
EGVIQKQKNI AGALAFWMAN ASELLNFIKQ DRDLSRITLD AQDVLAHLVQ MAFKYLVHCL
QSELNNYMPA FLDDPEENSL QRPKIDDVLH TLTGAMSLLR RCRVNAALTI QLFSQLFHFI
NMWLFNRLVT DPESGLCSHY WGAIIRQQLG HVEAWAEKQG LELAADCHLS RIVQATTLLT
MDKYAPDDIP NINSTCFKLN SLQLQALLQN YHCAPDEPFV PTDLMEHVVA VAENTADELA
RSDGREVQLE EDPDLQLPFL LPEDGYSCDV VRNIPNGLQE FLDPLCQRGF CRLIPHPRSP
GTWTIYFEGA DYESHLMREN TELAQPLRKE PEIITVTLKK QNGMGLSIVA AKGAGQDKLG
IYVKSVVKGG AADVDGRLAA GDQLLSVDGR SLVGLSQERA AELMTRTSSV VTLEVAKQGA
IYHGLATLLN QPSPMMQRIS DRRGSGKPRP KSEGFELYNN SAQNGSPESP QMPWAEYSEP
KKLPGDDRLM KNRADHRSSP NVANEPPSPG GKGAYASGTA AKITSVSTGN LCAEEQTPPP
RAEAYPIPTQ TYTREYFTFP ASKSQDRTAP PQDQWPRYEE KPHVHTDSSH SSTAVQRVTR
SQEELREDVG FHLERQRVEA AMERRSDGGD AWLNQGSSLG SSASSQEHLG PPSRAGTPAS
TLTKSGPGRW KTPAASPPVR TDPPPGHYGA GDGDSVPADS PLPPPPTGAQ VAAERKKREE
QQRWYEKEKA RLEEERERRR REQERRLGQL RAQAPPPGAP PPGPAAPPPG PAPARAPDTV
IRELQPQQQP RTIERRDLQY ITVSREELAS GDSLSPDPWK RDAREKLEKQ QQLHIVDLLS
REIQELQGKA ERSAEESDRL RKLMLEWQFQ KRLQESKQKD EDDEEEEDDD VDTVLLMQRL
EAERRARQTA MPAISVLDLL QDEERRRQQQ LEEMRTREAE ERARQEEQRA RREAEEKRRQ
EEGYYSRLEA ERRRQHDEAE RQLLEPEELG LGRPPLPRGY EPPAPGPPPP PQRTASYLQA
QVLSPDALYS AKLVAYTEEE EEEEEEEDGG PAGPNSYVGS AGTLIGAHDV YRDPREKPSK
SQDADVPGGP GAPENLTFRE RQRLFSQGHD VSNKVKASRK LTELENELNT K
//
