ID   A0A455BPE9_PHYMC        Unreviewed;      5829 AA.
AC   A0A455BPE9;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Nesprin-1 isoform X1 {ECO:0000313|RefSeq:XP_028350617.1};
GN   Name=SYNE1 {ECO:0000313|RefSeq:XP_028350617.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028350617.1};
RN   [1] {ECO:0000313|RefSeq:XP_028350617.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028350617.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the nesprin family.
CC       {ECO:0000256|ARBA:ARBA00008619}.
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DR   RefSeq; XP_028350617.1; XM_028494816.1.
DR   Proteomes; UP000248484; Chromosome 10.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR   CDD; cd00176; SPEC; 8.
DR   Gene3D; 1.20.58.60; -; 25.
DR   InterPro; IPR039906; Anc-1/SYNE1/2-like.
DR   InterPro; IPR012315; KASH.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR21524; SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR   PANTHER; PTHR21524:SF7; SPECTRIN REPEAT CONTAINING, NUCLEAR ENVELOPE 1; 1.
DR   Pfam; PF10541; KASH; 1.
DR   Pfam; PF00435; Spectrin; 10.
DR   SMART; SM01249; KASH; 1.
DR   SMART; SM00150; SPEC; 31.
DR   SUPFAM; SSF46966; Spectrin repeat; 32.
DR   PROSITE; PS51049; KASH; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00385}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   TOPO_DOM        1..5778
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT   TOPO_DOM        5800..5829
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT   DOMAIN          5770..5829
FT                   /note="KASH"
FT                   /evidence="ECO:0000259|PROSITE:PS51049"
FT   REGION          2886..2912
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3221..3241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5276..5315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5703..5765
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          776..829
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1134..1192
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1301..1331
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1742..1769
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1799..1833
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2094..2152
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2383..2410
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2760..2828
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3089..3116
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3154..3213
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3259..3286
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          4089..4123
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          4195..4225
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          4844..4871
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        2889..2912
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3221..3235
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5276..5306
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5703..5763
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   5829 AA;  668926 MW;  83717AAD5077F3DF CRC64;
     MQALRADWKH WEDSVFQTQT SLENLVSQMA LSEQEFSGQV AQLEEALQQF GALLTSWAQQ
     LALLEGKNTD QELVECWQKG REILDALQKA EPQTEDLKSQ LNELCRFSRD LSTYSRKVSG
     LIKEYNCLCL QASKGCQNKE QILQQRFQRA FKDFQQWLIH AKITTAKCFD IPQNISEVSA
     SLQKIQEFLS ESENGQHKLN MMLSKGELLS TLLTKEKASG IQAKIATAKE DWKNFHSNLH
     QKESALENLK IQMKDFEVSA EPVQDWLSKT EKMVHESSNR LYDLPAKRRE QQKLQEKVSR
     LDRIVAEHNQ FSLGIKDLQD WMTDAVHMLD SYYHPTSDKS VLDSRMLKLE ALLSGRQEKE
     IQMKMIVTRG ESVLQNTSPE GIPAIQRQLQ SAKDMWASLL SAAIRCKSQL EGALSKWTSY
     QDDVRQFSSW MDSVEASLNE SERQYAEVRE KTAALGKVKL LNEEVLSHSS LLETIEVKGA
     GMTEHYVTQL EFQDLQERYR DIRARTKEAV TKSEKLVRLH QEYQRDLKAF EAWLEQEQEK
     LDRYSVLEGD VHTHETTVRD LQELQVHCAE GQALWHSVLH TREEVIPSGI PQTEDRALES
     LRQDWQAYQQ RLSETRTRFN NVVNKLRLME QKFQQVDEWL KAMEDKVSLR SGRQSNRAAK
     EIHLHQMKKW HEEVTAYRDE VEEVGTRAQE ILDESHVSSR MGYQATQLTS RYQALLLQVL
     EQIKFLEEEI QSLEESELSL SSYADWYSST HKNFKNVAAK IDKVDKVMMG KKMKTLEVLL
     KDMEKGQSLL KSAREKGERA LTYLEGGEAE TLRKEIHAHV EQLKELTSTV RKEHMTLEKG
     LHLTKEFSDK YKALTQWIAE YREILHIPEE PKMELYEKKA QLSKYKSLQQ TVLSHEPSVK
     SVREKGEALL ELVQDVTLKD KIDQLQSDYQ NLCSAGKEHV CRLEVKVRDH EDYNGELQEV
     EKWLLQMSGK LVAPDLMETS SLEMVTQQLA HHKATMEEIA GFEDRLNNLK IKGDNLISQC
     ADHLQAKLKQ NVHAHLQGTK DSYSAICSTA QRVYQSLEHE LQKHVSRQDT LQQCQAWLSA
     VQPDLKPSAH PPLSRAEAVK QVKHFRALQE QARTYLDLLC TMCDLSNSSV KTTAKDIQQT
     EQMIEQRLTQ AQNLTRGWEE IKHMKSELWI YLQDASQQLQ NMKRRHSELE LNIAQNMVSQ
     VKDFVKKLQC KQSSVTTVTE KVNELTKKQE SPEHKEISHL NDQWLDLCLQ SNNLCLQREE
     DFQRTRDYHN CMNVVEVFLE KFTTEWDNLA RSDAESTASH LEALKKLALA LQERKQAIED
     LKERKQNMID HLNVDDKELV KEQTSHLEQR WFQLEDLVER KIQVSVTNLE ELSVVRSRFQ
     ELMDWAEEQR PNIAEALKQS PPPDMAQNLL MDHLAICSEL EAKQMLLKSL MKDADRVMAD
     LGLNERQIIQ KVLSDAQRHV NSLSDLVGQR RKYLNKALSE KTQFLMAVFQ ATSQIQQHER
     KIMFREHICL LPDDVSKQVK TCKSAQASLK TYQNEVTGLW AQGRELMKGV TEQEKSEVLG
     KLQELQSVYD TVLQKCSHRL QELEKNLVSR KHFKEDFDKA CHWLKQADIV TFPEINLMNE
     SAELHTQLAK YQHILEQSPE YENLLLTLQR TGQAVLPTLN DVDHSYLNEK LNALPLQFSV
     IVDLAKDKFY KVQEAILARK EYDSLIELTS QSLCDLEDQF SKVSQVPSDL SVEEALCLQD
     ACRALGGEVA ALAEAVDELN QKKESFRSTG QPWQPDQMLH LVAVYHRLKR QTEQRVSLLE
     DTTSAYQEHE KMCHQLEKQL EAVRTEQAKV NEETLPAEEK LKVYHSLAGS LQDSGILLKR
     VTVHLEDLVP HLDPSAYEKA KRQIQAWQEV LKLLTSAIGV TVTECESRMV QSRDFQTELS
     RSLDWLRSVE TALSGPLCLD LNLRDVQEEI RKVQIHQEEV QSSLRIMNAL SNKEKEKFTR
     AKELISADLQ HTLAELSELD GALQEALRTR QATLTQMYSQ CQRYYQVFQA ANDWLDDAHE
     MLQLTGNGLD VESAEESLKN HMEFFSTEDQ FHSNLEELQG LVANLDPLIK PTGKEDLAEK
     MASLEEKSQG TIQDSHVQLD LLQRCAAQWQ HYQKAREEVI ELMNDAEKKL SEFSLLKTSS
     SREAEEKLSE HKALVSVVNS FHEKIVALEG KASELERTGN GASKATISRS MTAVWQRWTR
     LRAVAQDQEK ILEDAVDEWK SFNNKVKKAT EMMNKLQDKL PGSSAEKASK AELLTLLEYH
     DTFILELEQQ QSGLRMLKQQ ALSMLQDGAT LSPGEEPSTV QEITAMQDRC LNIQENVKKN
     GKMVRQELKE REVVETQINS VKSWVQETKE YLGNPTIEID AQLEELQILL TEATNHRQNI
     EKMAEEQKNK YLGLYTILPS ELSLQLAEVA LDLGTIHDQI QDKIKEVEQS KAMSQEFSQQ
     IQKIAKDLTT ILTKLRAKTD NLVQAKTDQK VLGKELDVCN LKLLDLDEAV QKFSEQNGQL
     GKPLAKKIGK LTELHQQAIR QADNRLCKLS QAASHLEEYN EMLESILKWI EKAKVSVHGK
     IAWNSASQLR EQCISHQTVL EESEEIYNNL EVMAEKLQYL DGVYHTEKMS QQVADLGRDT
     EGLRQMIRIH LQNLYDAAKD MKKFETELRN LQVALEQAQT TLTSPEVGRL SLKEQLSHRQ
     HLLSEMESLK PKVHAVQMSQ SALRIPEDVV SSLPLCHAAL RLQEGASRLQ HTAIQQCNIM
     QEAVVQYEQY EQEMQHLQEL IEGAHREIEN KPVVTSNIQE LQAQISRHEE LAQKIKGFQE
     QITSLNSKCK MLTMKAKHAT MLLTVTDVER LAEGMEDLDG ELLPATSAHP SVVMMTAGRC
     HTLLSPVTEE SGEEGTNSEI SSSPACRSPS PVANTDASIN QDIAYYQALS AESLQTDASR
     ISPSTLPPQE LCEPRLEPSA TAKLDELQRS WETLKNVISE KQRTLYEALE RQQKYQDSLQ
     SVSTKMEAIE MKLSESPEHG RSTESQMAEH QSSPQALMDE ILMLQEEISE LQSALAEELM
     SDSPDSDPAE QLPLQSTLTV LAERMSTIKM KASGKRQLLE EKLNDQLEEQ RQEQALQRYR
     CEADELDHWL LSTKATLDIA LGSPKEPMDM EAQLVDCQNM LAEIEQKVVA LSELSVHNEN
     LLLEGKAHTK DEAEQLSVKL RTLKGSLLEL QRALHEKQVH IQQGTAQEKE ESDADLAATQ
     SPGVQEWLAQ ARTAWTQQRQ SSLQQQKELE QELAEQKSLL QSVASLGEEI LTQHSAAETS
     GGVGEKPDVL SQELGMEGQK SPAEDQLRMK WESLHQEFST KQKLLQNVLQ QEQEQVLYSR
     PNRLLSGMSP YKGDGRAQDK SAVTSLLNGL NQAFEEVSAQ GGGTKRQNTD LEQKLYDGVS
     ATSTWLDEVE ERLFAATALL PAEAETCLFN QETLAKDIKE MSEEMDKNKN LFSQAFPESG
     DNRDVIEDTL GCLLGRLSLL DSVVNQRCHQ MKERLQQILN FQNDLKVLFT SLADHKYIIL
     QKLANVFEQP VAEQIEAIQQ AEDGLKELDV GITELKRRGD KLQIEQPWVQ ELSKLQDMYD
     ELVMAVGSRR GGLNQNLALK SQYERALQDL ADLLETGREK MAGDQKIIVS SKEEIQQLLD
     KHKEYFQGLE SHMILTETLF RKVISFAVLR ETQFHTDLMA QASAVLKGAH KRGVELEYIL
     ETWSHLDEDH RELSRQLEVV ETSIPSVGLV EESEDRLIDR ITLYQHLKSS LNEYQPKLYQ
     VLDDGKRLLI SVSCSDLESQ LNQLGEHWLN DTNKVSKELH RLETILKHWT RYQSESADLI
     HWLQSAKDRL EFWTQQSVTV PQELEMVRDH LNAFLEFSKE VDAKSILKSS VLSTGNQLLR
     LKKVDTAALR SELSHIDGQW TDLLTNIPTV QEKLHQLQMD KLPSRHAISE VMAWISLMEN
     VIQMDEESIK NSIGYRAIHE YLQKYKGFKI DINCKQLTVD FVNQSVLQIS SQDVESKRSD
     KTDFAEQLGA MNKSWQILQG LVTEKIQLLE GLLESWSEYE NNVQCLKTWF ETQEKRLKQQ
     QRIGDQASVQ NTLKDCQDLE DLIKAKEKEV EKIEQNGLAL IQNKKEEVSG IVMSTLQDLN
     HTWANLDHMA GQLKILLKSV LDQWSRHKVA FDEINSYLME ARYSLSRFRL LTGSLEAVQV
     QVDNLQNLQD DLEKQEKSLQ KFGSVTNQLL KESHPPVTET LTNTLKEVNM RWNHLLEEIA
     EQLHASKALL QLWQRYRDYS KQCAATVQQQ EGRTHELLKA ATDKDIADDE VAIWIQDCND
     LLKGLGTVKD SLFVLHELGE QLKQQVDASA ASAIQSDQLC LSQHLCALEQ ALCKQQTMLQ
     AGVLDYETFT KSLEALEAWT VEAEEILQGQ DPSHSSDLST IQERMEELKG QMLKFSSMVP
     DLDRLNELGY RLPLNDKEIK RMQNLNRHWS LISSQTTERF SKLQSFLLQH QTFLEKCETW
     MEFLVQTEQK LAVEISGNYQ HLLEQQRAHE LFQAEMFSRQ QVLHSIIVDG QHLLEQGQVG
     DRDEFNLKLT LLSNQWQGVI RRAQQRRGII DSQIRQWQRY QEMAEKLRKW LVEVSYLPVS
     GLGSVPIPLQ QARTLFDEVQ FKEKVFLRQQ GSYILTVEAG KQLLLFADGA AEAALRAELA
     EIQERWRSAS VHLEEQKKKL AFLLQDWEKC ENGIADSLEK LRTFKKRLCQ PLPDHHEELH
     AEQMRGKELE NAVGSWTDDL ARLTVLKDAV CAYISADDIS ILNERMELLQ RQWEELCHQL
     SLRQQQVSER LNEWAVFSEK NKELCEWLTQ MESKISQNGD ILIEEMIEKL RKDYQEEIAI
     AQENKIQLQQ MGERLARASH ESKASEIEYK LGKINDRWQH LLDLMAARVK KLKETLVAVQ
     QLDKNMSSLR TWLAHIESEL AKPIVYDSCD SEEIQKKLNK QQELQRDIEK HSTGVASVLN
     LCEVLLHDCD ACATDAECGS IQQATRNLDR RWRNICAVSM ERRLKIEETW RLWQKFLDDF
     SRFEDWLKCS ERVAAFPSSS GVLYTVAKDE LKKFEGFQRQ VHETLTQLEL INKQYRRLAR
     ENRTDAACSL KHMIHEGNQR WDNLQKRVTS ILRRLKHFIG QREEFETARD SILVWLTEMD
     LQLTNIEHFS ECDVQAKIKQ LKAFQQEISL NHNKIEQIIA QGEQLIEKSE PLDATFIEEE
     LDELRRYCQE VFGRVERYHK KLIRLPLPDD EHDLSDRELE LEETAALSDL HWRDTSADSV
     LSPQPSSNPS LSLAQPLQSE RSGRDTPASV DSIPLEWDHD YDLSRDLESA VSRALPSEDE
     EGPEDKDFYL QGAVGLSGDP STLESQIQQL GKALDDSHFQ MQQMENIIHS KTPTGPELDS
     SYRGYMKLLG ECSGSIDSVK RLEHKLTEEE EHFPGFVNLN STETQTAGVI DRWELLQAQA
     LSKEMRMKQN PQRWQQFHSD LNRVLTWLQE TEEDLEQLQR LQRSTDIQPI ALQIKKLKEL
     QKAVDHHKAI ILSINLCSSE FTQTGSEESQ DLQGRLSQMN GRWDRVCSLL EEWRGLLQDA
     LMQCQDFHEM SHSLLLMLEN IDRRKNEIVP VDSNLDAEIL QDHLKQLTQI RHELLESQLK
     VASLQDMSCQ LLVNAEGTDC LEAKEKVHVI GNRLKLLLKE VSRHIKELEK LLDMSSSQQD
     LSSWSSADEL DTSGSVSPTS GRSSPNRQKT PRGKCSLSQP GPSVNSPHSR SIKGGSDSSL
     SEPRPARSGR AFLFRVLRAA LPLQLLLLSL IGLACLIPMS EEDYSCALSN NFARSFHPML
     RYTNGPPPL
//