ID A0A455BT43_PHYMC Unreviewed; 994 AA.
AC A0A455BT43;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Proprotein convertase subtilisin/kexin type 6 isoform X1 {ECO:0000313|RefSeq:XP_028350988.2};
GN Name=PCSK6 {ECO:0000313|RefSeq:XP_028350988.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028350988.2};
RN [1] {ECO:0000313|RefSeq:XP_028350988.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028350988.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR RefSeq; XP_028350988.2; XM_028495187.2.
DR AlphaFoldDB; A0A455BT43; -.
DR Proteomes; UP000248484; Chromosome 11.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 4.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR PANTHER; PTHR42884:SF8; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 6; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00261; FU; 5.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 491..631
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 644..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 201
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 242
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 416
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 994 AA; 109037 MW; AEA01B63D074D786 CRC64;
MPPRAPPGPR PPPRAPAAGG DEDTDTDTGG AGGPGLRPLA PRPWRWLLLL ALPAACSAPP
PPRPVYTNHW AVQVLGGPAA ADRVAAAHGY LNLGQIGNLE DYYHFYHSKT FKRSALSSRG
PHTFLRMDPQ VKWLQQQEVK RRVKRQVRSD PQALYFNDPI WSNMWYMHCG DKNSRCRSEM
NVQAAWKRGY TGKNVVVTIL DDGIERNHPD LAPNYDSYAS YDVNGNDYDP SPRYDASNEN
KHGTRCAGEV AASANNSYCI VGIAYNAKIG GIRMLDGDVT DVVEAKSLGI RPNYIDIYSA
SWGPDDDGKT VDGPGRLARQ AFEYGIKKGR QGLGSIFVWA SGNGGREGDH CSCDGYTNSI
YTISVSSTTE NGYKPWYLEE CASTLATTYS SGAFYERKIV TTDLRQRCTD GHTGTSVSAP
MVAGIIALAL EANSQLTWRD VQHLLVKTSR PAHLKANDWK VNGAGHKVSH LYGFGLVDAD
ALVMEAKKWT AVPLQHSCVA VTDKRPRSIP VVQTLRTSAL TTACADHSDQ RVGYLEHVVA
RITISHPRRG DLQIHLISPS GTKSQLLAKR LLDHSNEGFT NWEFMTVHCW GEKAEGEWTL
EIQDMPSQVR NPEKQGKLKE WSLILYGTAQ HPYTTFSAHQ SRSRMLELSA PEPEPPMAAL
SPSQAEVPED EEDYTAPPSH GSPNILQTSV CHPECGDKGC DGPNADQCLN CVHFSLGSVK
TIRKCVSVCP LGYFGDMASR RCRRCHKGCE TCSGRGPTQC LSCRRGFYHH QEVNTCVTFC
PAGFYADENQ KNCLKCHPSC KKCMDEPEKC TVCKEGFSLA RGSCIPDCEP GTYFDSELIR
CGECHPTCQT CVGPSREECI HCAPNFHFQD WKCVPACGEG FYPEEMPGLP HKVCRRCDES
CLSCEGSSRN CSRCKTGFTQ LGTSCITNHT CSNGARSFRG ISGHPGQVGE GFEEVSAMSS
HTLLAGSILL ANSQREQNEF QGSTAPASEQ LLGP
//
