ID   A0A455BU62_PHYMC        Unreviewed;      1013 AA.
AC   A0A455BU62;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Folliculin-interacting protein 2 isoform X6 {ECO:0000313|RefSeq:XP_028347370.1, ECO:0000313|RefSeq:XP_028347371.1};
GN   Name=LOC102982825 {ECO:0000313|RefSeq:XP_028347370.1,
GN   ECO:0000313|RefSeq:XP_028347371.1, ECO:0000313|RefSeq:XP_054941764.1,
GN   ECO:0000313|RefSeq:XP_054941765.1, ECO:0000313|RefSeq:XP_054941766.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028347371.1};
RN   [1] {ECO:0000313|RefSeq:XP_028347370.1, ECO:0000313|RefSeq:XP_028347371.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028347370.1,
RC   ECO:0000313|RefSeq:XP_028347371.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004656}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the FNIP family.
CC       {ECO:0000256|ARBA:ARBA00007541}.
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DR   RefSeq; XP_028347370.1; XM_028491569.2.
DR   RefSeq; XP_028347371.1; XM_028491570.2.
DR   RefSeq; XP_054941764.1; XM_055085789.1.
DR   RefSeq; XP_054941765.1; XM_055085790.1.
DR   RefSeq; XP_054941766.1; XM_055085791.1.
DR   Proteomes; UP000248484; Chromosome 7.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR037545; DENN_FNIP1/2.
DR   InterPro; IPR028086; FNIP_C_dom.
DR   InterPro; IPR026156; FNIP_fam.
DR   InterPro; IPR028085; FNIP_mid_dom.
DR   InterPro; IPR028084; FNIP_N_dom.
DR   PANTHER; PTHR21634:SF11; FOLLICULIN-INTERACTING PROTEIN 2; 1.
DR   PANTHER; PTHR21634; UNCHARACTERIZED; 1.
DR   Pfam; PF14638; FNIP_C; 1.
DR   Pfam; PF14637; FNIP_M; 1.
DR   Pfam; PF14636; FNIP_N; 1.
DR   PRINTS; PR02073; FOLLICULNIP1.
DR   PROSITE; PS51836; DENN_FNIP12; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT   DOMAIN          60..1013
FT                   /note="UDENN FNIP1/2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51836"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          617..724
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          750..903
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..127
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        659..673
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        765..779
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        818..843
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1013 AA;  108937 MW;  71C67A143DF1531E CRC64;
     MCGCSARTTA RPGGRRDASG GVSHGQTRGT RARSRIWKCA RVGRDTGPPE LDSSWSCSEL
     DLNEIRLIVY QDCERRGRQV LFDSKAVHKI EEVATQKTED VPTKTPAKCC QGGGSGSLSS
     HGSSGGSLPH AKEQLPKYQY TRPASDVSML GEMMFGSVAM SYKGSTLKIH YIRSPPQLMV
     SKVFSARMGS FCGSTNNLQD SFEYISQDPN LGKLNTSQNN LGPCRTGSHL GVLQGCGGKP
     PPGAAEGGPL RLSRSASFFA VHSTPVDMPR RGQSEDRDSG IARSASLSSL LITPFPSPSS
     STSSSSSYQR RWLRSQTTSL ENGIIPRRST DETFSLAEET CSSNPAIVRR KKIAISLIFS
     LCEKEEAQRN FQDFFFSHFP LFESHMNRLK SAIEKAMISC RKIAESSLRV QFYVSRLMEA
     LGEFRGTIWS LYSVPRIAEP VWLAMVSSTL EKTQLCQRFL KEFTLLIEQI NKNQFFAALL
     TAVLTYHLAW VPTVMPVDHP PIKAFAEKRT SQLVNTLAKT HPYNPLWAQL GDLYGAIGSP
     VRLSRTVVLG KQKDVVQRIL YVLTYFLRCS ELQESQLACG ANCGPDGQAP AGSSVTTALE
     RGEVEESEYV VVTVSSEPAL LPPGPPDADT GDLCPQLAGR GGRGPEQSPA ARSVRRPRGA
     SCGDQESKKE AARGGPARPP SGAGACVGPA GGEESGGEVP TKLPDRSAAR PCPEGRPWGR
     PPWEKVTFHI GSSVSPDSDF ESRTKAVEER LRACRCAEPA RRPPAGPDAA REARDWLAPR
     CSRAPEASAG ARGVRTGAAR EAAETPGAPA DPTRALRKPW GRGGEDADAP ARSGREDAGF
     GREGGLPRNE SSDSALGDSD DDACAPASPA LGPGSDGDSE RDRPEGSPEV ELPLPRSQSI
     SSPHVRNFGR SLLAGYCPTY MPDLVLHGTG GDERLRRCLA ADLVHTVQTL RGKSWGPSTM
     AQSEVNAATL PTAAAKWTHE PWGSATLQGD GSCVLSPLEA YLQCPSRQFT TLP
//