ID A0A455BVF2_PHYMC Unreviewed; 3300 AA.
AC A0A455BVF2;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=WD repeat and FYVE domain-containing protein 3 isoform X7 {ECO:0000313|RefSeq:XP_028347806.1};
GN Name=WDFY3 {ECO:0000313|RefSeq:XP_028347806.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028347806.1};
RN [1] {ECO:0000313|RefSeq:XP_028347806.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028347806.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_028347806.1; XM_028492005.2.
DR Proteomes; UP000248484; Chromosome 7.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF1; WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2550..2675
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2702..2995
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3142..3183
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 2500..2541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3300 AA; 369908 MW; 939EE1730B468705 CRC64;
MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFTELCHPPR HMTQKEQEEK LYMMLPVFNR
VFGNAPPNTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS TEKQCAPLSS KDFKATTPSE
AASRAIVQFL EINQSEEASR GWMLLTTINL LASSGQKTVD CMTTMSVPST LVKCLYLFFD
LPHVPEAVGG AQNELPLAER RGLLQKVFVQ ILVKLCSFVS PAEELAQKDD LQLLFSAITS
WCPPYNLPWR KSAGEVLMTI SRHGLSVNVV KYIHEKECLS TCVQNMQQSD DLSPLEIVEM
FAGLSCFLKD SSDVSQTLLD DFRIWQGYSF LCDLLLRLEQ AKEAESKDAL KDLVNLITSL
TTYGVSELKP AGITTGAPFL LPGFAVPQPA GKGHSVRNVQ AFAVLQNAFL KAKTNFLAHI
ILDAITNIYM ADNANYFILE SQHTLSQFAE KISKLPEVQN KYFEMLEFVV FSLNYIPCKE
LISVSILLKS SSSYHCSIIA MKTLLKFTRH DYIFKDVFRE VGLLEVMVNL LHKYAALLKE
PTQALNEQGD SRNNSSFEDQ KHLALLVMET LTVLLQGSNT NAGIFREFGG ARCAHNIVRY
PQCRQHALMM IQQLVLSPNG DDDMGTLLGL MHSAPPTELQ LKTDILRALL SVLRESHRSR
TVFRKVGGFV YITSLLVAME RSLSSPPKNG WEKVNQNQVF ELLHTVFCTL TAAMRYEPAN
SHFFKTEIQY EKLADAVRFL GCFSDLRKIS PMNVFPSNTQ PFQRLLEEDV ILMDSVSPTL
RHCSKLFIYL YKVATDSFDS RAEQIPPCLT SESSLPSPWG TPALSRKRHA YHSVSTPPAY
PPKNVADLKL HVATSSLQSS DAVIIHPGAM LSMLDLLASV GSVTQPEHAL DLQLAVANIL
QSLVHTERNQ QVMCEAGLHA RLLQRCSAAL ADEDHSLHPP LQRMFERLAS QALEPMVLRE
FLRLASPLNC GAWDKKLLKQ YRVHKPSSLS YEPEMRSSVI TSMEGLGSDS VFSLHEDNHY
RISKSLVKSA EGSTVPLTRV KCLVSMTTPH DIRLHGSSVT PTFVEFDTSL EGFGCLFLPS
LAPHNAPTNN AVTTGLTDGA VVSGIGSGER FFPPPSGLSY SSWFCIEHFS SPPNNHPVRL
LTIVRRANSS EQHYVCLAIV LSAKDRSLIV STKEELLQNY VDDFSEESSF YEILPCCARF
RCGELIIEGQ WHHLVLVMSK GMLKNSTATL YIDGQLVSTV KLHYVHSTPG GSGSANPPVV
STVYAYIGTP PAQRQIASLV WRLGPTHFVE EVLPPSNVTT IYELGPNYVG SFQAVCMPCK
DAKSEGVVPS PVSLVPEEKV SFGLYALSVS ALTVARIRKV YNKLDSKAIA KQLGISSHEN
ATPVKLIHNS AGHLNGPART IGATLIGYLG VRTFVPKPVA TTLQYIGGAA AILGLVAMAS
DVEGLYAAVK ALVCVVKSNP LASKEMERIK GYQLLAMLLK KKRSLLNSHI LHLTFSLVGT
VDSGHETSII PNSTAFQDLL CDFEVWLHAP YELHLSLFEH FIELLTESSE ASKNAKLMRE
FQLIPKLLLT LRDMSLSQPT IAAISNVLSF LLQGFPNSND LLRFGQFISS TLPTFAVCEK
FVVMEINHEE KPDTGTEEEF GGLVSANLIL LRNRLLDILL KLVYTSKEKT SINLQACEEL
VRTLGFDWIM MFMEEHLHST TVTAAMRILV VLLSNQSILI KFKEGLSGGG WLEQTDSVLT
NKIGTVLGFN VGRSAGGRST VREINRDACH FPGFPVLQSF LPKHTNVPAL YFLLMALFLQ
QPVSELPENL QVSVPVISSR CKQGCQFDLD SIWTFIFGVP ASSGTVVSSI HNVCTEAAFL
LLGMLRSMLN SPWQSEEEGS WLREYPVTLM QFFRYLYHNV PDLASMWMSP DFLCALAATV
FPFNIRPYSE MVTDLDDEVG SPAEEFKAFA ADTGMNRSQS EYCNVGVKTY LTNHPAKKFV
FDFMRVLIID NLCLTPASKQ TPLIDLLLEA SPERSTRTQQ KEFQTYILDS VMDHLLAADV
LLGEDASLPI TSGGSYQVLV NNVFYFTQRV VDKLWQGMFN KESKLLIDFI IQLIAQSKRR
SQGLSLDAVY HCLNRTILYQ FSRAHKTVPQ QVALLDSLRV LTVNRNLILG PGNHDQEFIS
CLAHCLINLH VGSNVDGFGL EAEARMTTWH IMIPSDIEPD GGYSQDISEG RQLLIKAVNR
VWTELIHSKK QTLEELFKVT LPVNERGHVD IAIAKPLIEE AGLKCWQNHL AHEKKCISRG
EALVPTTQSK LSRVSSGFGL SKLTGSRRNR KESGLHKHSL STQEISQWMF THIAVVRDLV
DTQYKEYQER QQNALKYVTE EWCQIEYELL RERGLWGPPI GSHLDKWMLE MTEGPCRMRK
KMVRNDMFYT HYPYVPETEQ ETNVASEIPS KQPETPDDII PQKKPARYRR AISYDSKEYY
MRLASGNPAI VQDAIVESSE GEATQQEPEH GEDTIAKVKG LVKPPLKRSR SAPDGGDEET
QEQLQDQIAE GSSIEEEEKT DNATLLRLLE EGEKIQHMYR CARVQGLDTS EGLLLFGKEH
FYVIDGFTMT ATREIRDIET LPPNMHEPII PRGARQGPSQ LKRTCSIFAY EDIKEVHKRR
YLLQPIAVEV FSGDGRNYLL AFQKGIRNKV YQRFLAVVPS LTDSSESVSG QRPNTSVEQG
SGLLSTLVGE KSVTQRWERG EISNFQYLMH LNTLAGRSYN DLMQYPVFPW ILADYDSEEV
DLTNPKTFRN LAKPMGAQTD ERLAQYKKRY KDWEDPNGET PAYHYGTHYS SAMIVASYLV
RMEPFTQIFL RLQGGHFDLA DRMFHSVREA WYSASKHNMA DVKELIPEFF YLPEFLFNSN
NFDLGCKQNG TKLGDVILPP WAKGDPREFI RVHREALECD YVSAHLHEWI DLIFGYKQQG
PAAVEAVNVF HHLFYEGQVD IYNINDPLKE TATIGFINNF GQIPKQLFKK PHPPKRVRSR
LNGDNAGILV PPGSTGDKIF FHHLDNLRPS LTPVKELKEP VGQIVCTDKG ILAVEQNKVL
IPPTWNKTFA WGYADLSCRL GTYESDKVVT VYECLSEWAQ ILCAICPNPK LVITGGTSTV
VCVWEMGASK EKAKILTLKQ ALLGHTDTVT CATASLAYHI IVSGSRDRTC IIWDLNKLSF
LTQLRGHRAP VSALCINELT GDIVSCAGTY IHVWSINGSP VVSVNTFTGR SQQIICCCVS
EMNEWDTQNV IVTGHSDGVV RFWRMEFLQV PETPAPETVE VLEMQEDCPE AQIVTYIYFP
//
