ID A0A455BVZ3_PHYMC Unreviewed; 2015 AA.
AC A0A455BVZ3;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Ankyrin-2 isoform X12 {ECO:0000313|RefSeq:XP_028347991.1};
GN Name=ANK2 {ECO:0000313|RefSeq:XP_028347991.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028347991.1};
RN [1] {ECO:0000313|RefSeq:XP_028347991.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028347991.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_028347991.1; XM_028492190.1.
DR Proteomes; UP000248484; Chromosome 7.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08804; Death_ank2; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 80..112
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 113..145
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 146..178
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 249..281
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 282..314
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 315..347
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 348..380
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 381..413
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 414..446
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 447..479
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 480..512
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 513..545
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 546..578
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 579..611
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 612..644
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 645..677
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 678..710
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 711..743
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 744..776
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 777..809
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 997..1152
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1154..1300
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1480..1564
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1455..1478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1601..1625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1639..1664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1684..1792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1822..1842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1859..1884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1601..1622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1684..1733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1734..1753
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1766..1781
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1859..1882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2015 AA; 222025 MW; B45E937ACAE2F34E CRC64;
MGNAALCPSC HADKSVRAQE HLQELDKTPD YYGCNSEDTK ELGVRSDSNA SFLRAARAGN
LDKVVEYLKG GIDINTCNQN GLNALHLAAK EGHVGLVHEL LGRGSAVDSA TKKGNTALHI
ASLAGQAEVV KVLVKEGANI NAQSQNGFTP LYMAAQENHI DVVKYLLENG ANQSTATEDG
FTPLAVALQQ GHNQAVAILL ENDTKGKVRL PALHIAARKD DTKSAALLLQ NDHNADVQSK
MMVNRTTESG FTPLHIAAHY GNVNVATLLL NRGAAVDFTA RNGITPLHVA SKRGNTNMVK
LLLDRGGQID AKTRDGLTPL HCAARSGHDQ VVELLLERGA PLLARTKNGL SPLHMAAQGD
HVECVKHLLQ HKAPVDDVTL DYLTALHVAA HCGHYRVTKL LLDKRANPNA RALNGFTPLH
IACKKNRIKV MELLVKYGAS IQAITESGLT PIHVAAFMGH LNIVLLLLQN GASPDVTNIR
GETALHMAAR AGQVEVVRCL LRNGALVDAR AREEQTPLHI ASRLGKTEIV QLLLQHMAHP
DAATTNGYTP LHISAREGQV DVASVLLEAG AAHSLATKKG FTPLHVAAKY GSLDVAKLLL
QRRAAADSAG KNGLTPLHVA AHYDNQKVAL LLLEKGASPH ATAKNGYTPL HIAAKKNQMQ
IASTLLNYGA ETNIVTKQGV TPLHLASQEG HTDMVTLLLD KGANIHMSAK SGLTSLHLAA
QEDKVNVADI LTKHGADQDA HTKLGYTPLI VACHYGNVKM VNFLLKQGAN VNAKTKNGYT
PLHQAAQQGH THIINVLLPH GAKPNATTAN GNTALAIAKR LGYISVVDTL KVVTEEVTTT
TTTITEKHKL NVPETMTEVL DVSDEEGDDT MTGDGGEYLR PEDLKELGDD SLPSSQFLDG
MNYLRYSLEG GRSDSLRSFS SDRSHTLSHA SYLRDSAMID DTVVIPSHQV STLAKEAERN
SYRLSWGTEN LDNVALSSSP IHSGRTSPCL DRDNSSFLVS FMVDARGGAM RGCRHNGLRI
IIPPRKCTAP TRVTCRLVKR HRLATMPPMV EGEGLASRLI EVGPSGAQFL GPVIVEIPHF
AALRGKEREL VVLRSENGDS WKEHYCEYTE DELNEILNGM DEVLDSPEDL EKKRICRIIT
RDFPQYFAVV SRIKQDSNLI GPEGGVLSST VVPQVQAVFP EGALTKRIRV GLQAQPMHSE
LVKKILGNKA TFSPIVTLEP RRRKFHKPIT MTIPVPKASS DVMLNGFGGD APTLRLLCSI
TGGTTPAQWE DITGTTPLTF VNECVSFTTN VSARFWLIDC RQIQESVTFA SQVYREIICV
PYMAKFVVFA KSHDPIEARL RCFCMTDDKV DKTLEQQENF AEVARSRDVE VLEGKPIYVD
CFGNLVPLTK SGQHHIFSFF AFKENRLPLF VKVRDTTQEP CGRLSFMKEP KSTRGLVHQA
ICNLNITLPI YAKESESDQE QEEEIDMTSE KNQQDEQERI EERLAYIADH LGFSWTELAR
ELDFTEEQIH QIRIENPNSL QDQSHALLKY WLERDGKHAT DTSLIECLTK INRMDIVHLM
ETSTEPLQEH ISHSYAEIEQ TITLDHSEGF SVLQEELCTA QHKQKEQQAA SKEDESYDHP
PIVSEEDISV GYSTFQESIS KTEGDGSATE LLPQTHKEQV QQDFSGKMQD LPEESALEQQ
EYFVTTPETE VSETQKAMAA SGSPTQTPEE TSTPAEEERP YLQTPTSSER GDSPIVQEPE
EPPERREESS PRKTSLVIVE SADDQPQASE RLEEDAAFQK GDDMPDIPPE TVTEEEYIDE
QGHTVVKKIT RKIIRRYVSS DGTEKEEITM QGTPQDPINI EEGDGYSKVI KRIVLKSDTE
QSEVTLSEPS MLSSTSQFQA EPVEGRRVSK VVKTTVVHGE RMEKHLGDSS LATDLPSAKD
DFEEALSYTG SHMKVHSPSL VENEVLKEDG SILRRTTMSK ARTQKRAVVK DQHGKRIYLE
HLEDVPEALD QDDLQHDLKR LLRHFCKEDL KQEAK
//
