ID   A0A455BW52_PHYMC        Unreviewed;      1153 AA.
AC   A0A455BW52;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Potassium channel subfamily T member 1 isoform X10 {ECO:0000313|RefSeq:XP_028353229.1};
GN   Name=KCNT1 {ECO:0000313|RefSeq:XP_028353229.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028353229.1};
RN   [1] {ECO:0000313|RefSeq:XP_028353229.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028353229.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; XP_028353229.1; XM_028497428.2.
DR   AlphaFoldDB; A0A455BW52; -.
DR   Proteomes; UP000248484; Chromosome 13.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR013099; K_chnl_dom.
DR   InterPro; IPR047871; K_chnl_Slo-like.
DR   PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR   PANTHER; PTHR10027:SF14; POTASSIUM CHANNEL SUBFAMILY T MEMBER 1; 1.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF07885; Ion_trans_2; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303,
KW   ECO:0000313|RefSeq:XP_028353229.1};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958};
KW   Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        33..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        91..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        150..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        187..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        214..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        245..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          195..262
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
FT   DOMAIN          420..514
FT                   /note="Calcium-activated potassium channel BK alpha
FT                   subunit"
FT                   /evidence="ECO:0000259|Pfam:PF03493"
FT   REGION          596..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          983..1028
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1129..1153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1139..1153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1153 AA;  130505 MW;  4407F38E920D9BC1 CRC64;
     MVQVEFYVNE NTFKERLKLF FIKNQRSSLR IRLFNFSLKL LTCLLYIVRV LLDDPALGIG
     CWGCPKQNYT FNESSSEINW APILWVERRT ALWAIQVTVA IISFLETTLL IYLSYKGNIW
     EQIFRVAFIL EMINTLPFII TIFWPPLRNL FIPVFLNCWL AKHALENMIN DFHRAILRTQ
     SAMFNQVLIL FCTLLCLVFT GTCGIQHLER AGGNLSLLTS FYFCIVTFST VGYGDVTPKI
     WPSQLLVVVM ICVALVVLPL QFEELVYLWM ERQKSGGNYS RHRAQTEKHV ILCVSSLKID
     LLMDFLNEFY AHPRLQDYYV VILCPTEMDI QVRRVLQIPL WSQRVIYLQG SALKDQDLMR
     AKMDNGEACF ILSSRNEVDR TAADHQTILR AWAVKDFAPN CPLYVQILKP ENKFHVKFAE
     HVVCEEECKY ALLALSCICP ATPTLITLLV HTSRGQEGQD SPEQWQRMYG RCSGNEVYHV
     RMGDSKFFRE YEGKSFTYAA FHAHKKYGVC LIGLKREENK SILLNPGPRH ILAASDTCFY
     INITKEENSA FIFKQEEKQK KKGFAGQGLY EGSSRLPVHS IIASMGTVAM DLQNTECQPA
     QSGGGGGGSK LALPTENGSG SRRPSIAPVL EVADSSTLLP CDLLSDQSED EMAPSDEEGL
     SVVEYVKGYP PNSPYIGSSP TLCHLLPVKA PFCCLRLDKG CKHNSYEDAK AYGFKNKLII
     VSAETAGNGL YNFIVPLRAY YRPRRELNPI VLLLDNKPDH HFLEAICCFP MVYYMEGSVD
     KSHPGLSPRS LDSLLQCGII YADNLVVVDK ESTMSAEEDY MADAKTIVSV QTMFRLFPSL
     SITTELTHPS NMRFMQFRAK DSYSLALSKL EKRERENGSN LAFMFRLPFA AGRVFSISML
     DTLLYQSFVK DYMIPITRLL LGLDTTPGSG YLCAMKVTED DLWIRTYGRL FQKLCSSSAE
     IPIGIYRTEC HVFSSEPHNL RAQSQVSVSV EDREDTREAK GPWGSRAGTG GGGAHGPHAV
     GGGSAEHPLL RRKSLPWARR LSRKGARHAG KAAEWISQQR LSLYQRSERQ ELSELVKNRM
     KHLGLPTTGY EDVANLTASD VMNRVNLGYL QDEMNDQQNT LSYVLINPPP DTRLEPNDIV
     KRQTTQQENR PTT
//