ID   A0A455C1G0_PHYMC        Unreviewed;       555 AA.
AC   A0A455C1G0;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=COP9 signalosome complex subunit 1 isoform X1 {ECO:0000313|RefSeq:XP_028355185.1};
GN   Name=GPS1 {ECO:0000313|RefSeq:XP_028355185.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028355185.1};
RN   [1] {ECO:0000313|RefSeq:XP_028355185.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028355185.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the CSN1 family.
CC       {ECO:0000256|ARBA:ARBA00008793}.
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DR   RefSeq; XP_028355185.1; XM_028499384.2.
DR   AlphaFoldDB; A0A455C1G0; -.
DR   STRING; 9755.ENSPCTP00005026510; -.
DR   Ensembl; ENSPCTT00005029187; ENSPCTP00005026510; ENSPCTG00005018944.
DR   InParanoid; A0A455C1G0; -.
DR   OrthoDB; 1601at2759; -.
DR   Proteomes; UP000248484; Chromosome 14.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000338; P:protein deneddylation; IEA:Ensembl.
DR   Gene3D; 1.25.40.570; -; 1.
DR   InterPro; IPR048624; CSN1_C.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR019585; Rpn7/CSN1.
DR   InterPro; IPR045135; Rpn7_N.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR14145; 26S PROTESOME SUBUNIT 6; 1.
DR   PANTHER; PTHR14145:SF2; COP9 SIGNALOSOME COMPLEX SUBUNIT 1; 1.
DR   Pfam; PF21151; CSN1_C; 1.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF10602; RPN7; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT   DOMAIN          333..495
FT                   /note="PCI"
FT                   /evidence="ECO:0000259|PROSITE:PS50250"
FT   REGION          9..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          529..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          156..219
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        9..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        539..555
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   555 AA;  61881 MW;  1D57B4F98EA1B0D3 CRC64;
     MPLPVQVFNL QQPASSVSGS GGAESQDRMR GGPAPRAAAS SVADVHCAPP SGRSELFLPG
     TAGDFSLSAS LSACTLLYEG AVEPMQIDVD PQEDPQNAPD VNYVVENPTL DLEQYAASYS
     GLMRIERLQF IADHCPPLRV EALKMALSFV QRTFNVDMYE EIHRKLLEAA RELQNAPDAI
     PESGVEPPPL DTAWVEATRK KALLKLEKLD TDLKNYKGNS IKESIRRGHD DLGDHYLDCG
     DLSNALKCYS RARDYCTSAK HVINMCLNVI KVSVYLQNWS HVLSYVSKAE STPEIAEQRG
     ERDTQTQAIL TKLKCAAGLA ELAARKYKQA AKCFLLASFD HCDFPELLSP SNVAVYGGLC
     ALATFDRQEL QRNVISSSSF KLFLELEPQV RDIIFKFYES KYASCLKMLD EMKDNLLLDM
     YLAPHVRTLY TQIRNRALIQ YFSPYVSADM RKMATAFNTT VAALEDELTQ LILEGLINAR
     IDSHSKILYA RDVDQRSTTF EKSLLMGKEF QRRAKAMILR AAVLRNQIHV KSPPREGSQG
     ELTPANSQSR MSTNM
//