ID   A0A455C1H8_PHYMC        Unreviewed;       418 AA.
AC   A0A455C1H8;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Zinc finger protein 75D isoform X4 {ECO:0000313|RefSeq:XP_028355234.1};
GN   Name=LOC102996329 {ECO:0000313|RefSeq:XP_028355234.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028355234.1};
RN   [1] {ECO:0000313|RefSeq:XP_028355234.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028355234.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00187}.
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DR   RefSeq; XP_028355234.1; XM_028499433.2.
DR   AlphaFoldDB; A0A455C1H8; -.
DR   Proteomes; UP000248484; Chromosome 14.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd07765; KRAB_A-box; 2.
DR   CDD; cd07936; SCAN; 1.
DR   Gene3D; 6.10.140.140; -; 2.
DR   Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR003309; SCAN_dom.
DR   InterPro; IPR038269; SCAN_sf.
DR   PANTHER; PTHR45935; PROTEIN ZBED8-RELATED; 1.
DR   PANTHER; PTHR45935:SF24; SCAN BOX DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01352; KRAB; 2.
DR   Pfam; PF02023; SCAN; 1.
DR   SMART; SM00349; KRAB; 2.
DR   SMART; SM00431; SCAN; 1.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 2.
DR   SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR   PROSITE; PS50805; KRAB; 2.
DR   PROSITE; PS50804; SCAN_BOX; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT   DOMAIN          49..130
FT                   /note="SCAN box"
FT                   /evidence="ECO:0000259|PROSITE:PS50804"
FT   DOMAIN          258..329
FT                   /note="KRAB"
FT                   /evidence="ECO:0000259|PROSITE:PS50805"
FT   DOMAIN          351..418
FT                   /note="KRAB"
FT                   /evidence="ECO:0000259|PROSITE:PS50805"
FT   REGION          26..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   418 AA;  47521 MW;  878A7890634C25A3 CRC64;
     MMTIDLKVAE YLNPQIRTLW ETKGPVTGSS SHIKKYAPQT DSLSPERSHQ HFRSFLYHEA
     AGPREAVDQL LELCRRWLRP EIHSKEQILE LVVLEQFLSI LPRDTQTCIK KHHLRSIEEA
     VVLVEHLQRE SGQMRNGVAD HELGKEAVLL GETAEALGFK LKPAEAQQVG MSQDEEFWSM
     HQNLQELLIR NTHKETEPVH EREMSLGYSE TEAREISCGS PSPTAVSAHR ILAFPEQTNT
     KDWTVAPELI LTESQSLLTF EEVAMYFSQE EWELLDPTQK ALYNDVMQEN YETVISLELS
     LGCSKTEGRE ISSHSSTAVP AHQILAFPEQ TNAKDWTVAP ELILPESQSL LTFEEVAMYF
     SKEEWELLDP TQKALYSDVM QENYETVISL GGRAVGSKIP GVQGQFWRAA YSRAKAQK
//