ID A0A455C5F3_PHYMC Unreviewed; 570 AA.
AC A0A455C5F3;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Protein Atg16l2 isoform X8 {ECO:0000313|RefSeq:XP_028356659.1};
GN Name=ATG16L2 {ECO:0000313|RefSeq:XP_028356659.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028356659.1};
RN [1] {ECO:0000313|RefSeq:XP_028356659.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028356659.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat ATG16 family.
CC {ECO:0000256|ARBA:ARBA00009271}.
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DR RefSeq; XP_028356659.1; XM_028500858.2.
DR AlphaFoldDB; A0A455C5F3; -.
DR Proteomes; UP000248484; Chromosome 16.
DR GO; GO:0000045; P:autophagosome assembly; IEA:InterPro.
DR CDD; cd22887; Atg16_CCD; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR045160; ATG16.
DR InterPro; IPR013923; Autophagy-rel_prot_16_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19878; AUTOPHAGY PROTEIN 16-LIKE; 1.
DR PANTHER; PTHR19878:SF7; PROTEIN ATG16L2; 1.
DR Pfam; PF08614; ATG16; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 17..208
FT /note="Autophagy-related protein 16"
FT /evidence="ECO:0000259|Pfam:PF08614"
FT REPEAT 333..374
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 377..418
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 419..460
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 507..536
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT COILED 119..222
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 570 AA; 62993 MW; 844D3EA65815FA79 CRC64;
MAGPSDPGVP AARWKRHIVR QLRQRDRTQK ALFLELVPAY NRLLEKAELL AQFSEKLQPE
PTAVTRALHQ GAWEEESGPD SYQVPSPAAL RVKWQEEEEG LRLVCGEMAY QVVEKSAALG
TLESQLEERQ SRLAALEARV AQLQEAREKE AGQVDARRAL NAAQRAAYEA LRVHVGHQEA
ALRRLEEEAR DLLDRLVRRK ARAAAERNLR NERRERAKQA RVSQELKKAA KRTVSISESP
DTLGDGIREE ADTLALAAEP AFLESEVGEK WKRPFRSASA TSLTLSRCVD VVKGLLDFKK
RRGHSVGGAP EQRYQSIPVC VAARLPTRAQ DVLDAHLSEV NAVRFGPSSS LLATGGADRL
ILLWNVVGGR LEANQTLEGA GGSITSVDFD PSGSQVLAAT YNKAAQLWKV GEAQSKETLS
GHTDKVTAAK FKLTRHQAVT GSRDRTVKEW DLGRAYCSRT INVLSYCNDV VCGDHVIISG
HNDQKIRFWD SRADGFRCGS DWTKAVFSPD RSYALAGSWD GALYIWDVDT GKLESSLRGP
HCAAVNAVAW CYSGSHVVSV DQARKVVLWH
//
