ID A0A455C7M1_PHYMC Unreviewed; 349 AA.
AC A0A455C7M1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=SPARC-related modular calcium-binding protein 1 {ECO:0000313|RefSeq:XP_028351901.1};
GN Name=SMOC1 {ECO:0000313|RefSeq:XP_028351901.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028351901.1};
RN [1] {ECO:0000313|RefSeq:XP_028351901.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028351901.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR RefSeq; XP_028351901.1; XM_028496100.1.
DR AlphaFoldDB; A0A455C7M1; -.
DR STRING; 9755.ENSPCTP00005024043; -.
DR KEGG; pcad:102973863; -.
DR InParanoid; A0A455C7M1; -.
DR OrthoDB; 5388426at2759; -.
DR Proteomes; UP000248484; Chromosome 11.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd00191; TY; 2.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 2.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR12352; SECRETED MODULAR CALCIUM-BINDING PROTEIN; 1.
DR PANTHER; PTHR12352:SF13; SPARC-RELATED MODULAR CALCIUM-BINDING PROTEIN 1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF16597; Thyroglob_assoc; 1.
DR Pfam; PF00086; Thyroglobulin_1; 2.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00211; TY; 2.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 2.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..349
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019865575"
FT DOMAIN 37..89
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 92..158
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 224..292
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 149..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 129..136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 138..158
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 262..269
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 349 AA; 38165 MW; E7E78BC1C265F11B CRC64;
MLLARCARLL APHLLLVLVQ LSPARGHRTT GPRFLISDRD PQCNLHCSRT QPKPICASDG
RSYESMCEYQ RAKCRDPTLG VVHRGRCKDA GQSKCRLERA QALEQAKKPQ EAVFVPECSE
DGSFTQVQCH TYTGYCWCVT PDGKPISGSS VQNKTPVCSG SVTDKPVSQG NSGRKDDGSK
PTPTMETQPV FDGDEITAPT LWIKHLVIKD SKLNNTNVRN SEKVHSCDQE RQSALEEAQQ
NPREGIVIPE CAPGGLYKPV QCHQSTGYCW CVLVDTGRPL PGTSTRYVMP SCESDARAKS
AEVDDPFKDR ELPGCPEGKK MEFITSLLDA LTTDMVQAIN SAAPTGGGR
//
