ID A0A455C8T8_PHYMC Unreviewed; 2123 AA.
AC A0A455C8T8;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Dysferlin isoform X7 {ECO:0000313|RefSeq:XP_028352656.1};
GN Name=DYSF {ECO:0000313|RefSeq:XP_028352656.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028352656.1};
RN [1] {ECO:0000313|RefSeq:XP_028352656.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028352656.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004483}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR RefSeq; XP_028352656.1; XM_028496855.2.
DR Proteomes; UP000248484; Chromosome 12.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF33; SPERM VESICLE FUSION PROTEIN FER-1; 1.
DR Pfam; PF00168; C2; 7.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 7.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 7.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2089..2110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..102
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 211..329
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 368..504
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1144..1270
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1332..1460
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1604..1722
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1838..1986
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 130..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2038..2060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..204
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2123 AA; 241285 MW; FC3E26C7C1F9D853 CRC64;
MLSCQLVRAS NLPSVKKDRR SDPVASLTFR GVKKRTKVIK NNVNPVWNEG FEWDLKGVPL
DQGSELHVVV KDHETMGRNR FLGEANVPLR EVLATPSLSA SFNAPLLDTK KQPTGASLVL
QVSYTPLPGT MPTFPPSTPL EPSPTLPDMD MVAAPSPPDT GGEEDTEDQG LTGDEAEPFL
DQSGAPGPGA PMTPKKPPSH PPPYHPGGRR KRSTPAPRKP LSDKSQDFQI RVQVIEGRQL
PGVNIKPVVK VTAAGQTKRT RIHKGNSPLF NETLFFNVFD SPAELFDEPI FITVVDSCSL
RTDALIGEFR MDVGSIYREP RHAYLRKWLL LSDLDDFSAG ARGYLKVSLC VLGPGDEAPL
ERKDPSEDKE DIEGNLLRPT GVALRGAHFC LKVFRAEDLP QMDDAVMDNV KQIFGFESNK
KNLVDPFMEV SFAGKMLCSK ILEKTANPQW NQSITVPAMF PSMCEKMRIR VIDWDRLTHN
DIVATTYLSM SKISASGGEI EEEPAGVVTS PPATDLDDHL GFLPTFGPCY VNLYGSPREF
TGFPDPYAEL NTGKGEGVAY RGRLLLSLET KLVEHSEQKV EDLPADDILR VEKYLRRRKY
SLFAAFYSAT MLQDVDDAVQ FEVSIGNYGN KFDTTCLPLA STTQYSRAVF DGCHYYYLPW
GNVKPVVVLS SYWEDISHRI EAQNQLLRIA DRLEAGLEQV HLALKAQRSA EDVDSLVAQL
MDELIAGCSQ PLGNIQETPS ATHLDHYLYR LRTRHLSQIT EAAQALKLGH SELPTALEQA
EDWLLRLRAL ADEPQNSLPD IVIWMLQGDK RVAYQRVPAH EVLFSRRGTG YCGKNCGKLQ
TMFLKYPMEG VPGARMPVQI RVRLWFGLSV DEKEFNQFAE GKLSVFAETY ENQTKLALVG
NWGTTGLTYP KFSDVTGKIK LPKESFRPSA GWAWAGDWFV CPEKTLLHDT DAGHLSFVEE
VFENQTRLPG GQWIYMSDNY TDVNGEKVLP KDDIECPLGW KWEDEEWSTD LNRAVDEQGW
EYSITIPPDR KPRHWVPAEK MYYTHRRRRW VRLRRRDLSQ MEALKRHRQA EAEGEGWEYA
SLFGWKFHLE YRKTDAFRRR RWRRRMEPLE KTGPAAVFAL EGALGGVVDD RSEDSKSVST
LSFGVNTPTI SCIFDYGNRY HLRCYMYQAR DLPAMDKDSF SDPYAIVSFL HQSQKTVVVK
NTLNPTWDQT LIFYEIEIFG ELASIAEQPA SIVVELYDHD TYGADEFMGR CICQPSLERM
PRLAWFPLTR GNQPAGELLA SFELIQREKP AIHHIPGFEV QDTSGILEEL CAPAVFLQGL
LQTSEDTDLP YPPPQREANI YMVPQNIKPV LQRTAIEILA WGLRNMKSYQ LASVSSPSLV
VECGGQTVQS CVIKNLRKNP NFDICTLFME VMLPREELYC PPIVIKVIDN RQFGRRPVVG
QCTIRSLESF LCDPYSEESP SPQGGPDDVS LLSPGEDVLI DIDDKEPLIP IQLADGLSGF
APTNMASSPS SRHEEEFIDW WSKFFASIGE REKCGSYLEK DFDTLKVYDT PLENVKDFEG
LSDFCNTFKL YRGKTQEEME DPSVIGEFKG LFKIYPLPED PAIPIPPRQF HQLASQGPQE
CLVRIYVIRA FGLQPKDPNG KCDPYIRISI GKKSVSDQDN YIPCTLEPVF GKMFELTCTL
PLEKDLKVTL YDYDLLSKDE KIGETVIDLE NRLLSKFGAR CGLPQTYCVS GPNQWRDQLH
PSQLLHLFCQ QHRVKAPVYR TDRVVFQDKE YTIEEIEAGR VPNPHLGPVE ERLALHVLQQ
QGLVPEHVES RPLYSPLQPD IEQGKLQMWI DLFPKALGRP GPPFNITPRR ARRFFLRCVI
WNTKDVILDD LSITGEKMSD IYVKGWMVGF EEHKQKTDVH YRSLGGEGNF NWRFIFPFDY
LPAEQVCTVS KKDAFWRLDK TESKIPARVL FQIWDNDKFS FDDFLGSLQL DLNRMPKPAK
TAEKCSLDQL DDTFHPEWFV SLFEQKTVKG WWPCVADEGE KKILAGKLEM TLEIVAESEH
EERPAGQGRD EPNMNPKLED PRRPDTSFLW FTSPYKTMKF ILWRRFRCAI ILFIILFILL
LFLGIFVYSF PNYTAMKLVK PFS
//
