ID A0A455C9J2_PHYMC Unreviewed; 723 AA.
AC A0A455C9J2;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Rho guanine nucleotide exchange factor 7 isoform X1 {ECO:0000313|RefSeq:XP_028353306.1};
GN Name=ARHGEF7 {ECO:0000313|RefSeq:XP_028353306.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028353306.1};
RN [1] {ECO:0000313|RefSeq:XP_028353306.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028353306.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_028353306.1; XM_028497505.2.
DR AlphaFoldDB; A0A455C9J2; -.
DR InParanoid; A0A455C9J2; -.
DR OrthoDB; 2879064at2759; -.
DR Proteomes; UP000248484; Chromosome 13.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46026:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 63..291
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 313..418
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 671..712
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 723 AA; 81684 MW; F37609DB8C812070 CRC64;
MSSRMERRGT GAEVQKGPKR KRFCPRGVGL PPSWHMEKPV SPKSGALRSP PKGFDTTAIN
KSYYNVVLQN ILETENEYSK ELQTVLSTYL RPLQTTEKLS SANTSYLMGN LEEICSFQQM
LVQSLEECTK NPGLVHRSWR LDAGEKDGLG WLLYGRTASE AGPSRRWLVV GAHTVWDWMP
EAQQRVGGCF LNLMPQMKTL YLAYCANHPS AVSVLTEHSE ELGEFMEMKG AGSPGILVLT
TGLSKPFMRL DKYPALLKEL ERHMEDYHPD RQDIQKSMTA FKNLSAQCQE VRKRKELELQ
ILTEAIRSWE GDDIKTLGNV IYMSQVLIQC AGSEEKNERY LLLFPNILLM LSASPRMSGF
IYQGKLPTTG MTITKLEDSE NHRNAFEISG SMIERIVVSC SSQQDLHEWV DRLQKQTRVT
SAGNPTVKPH SVPSHTLPSH SIAPSSKHAD SKPVPLTPAY HTLPHPSHHG TPHTTINWGP
LEPPKTPKPW SLSCLRPAPP LRPSAALCYK EDLSKSPKTM KKLLPKRKPE RKPSDEEFAL
RKSTAALEED AQILKVIEAY CTSAKTRQTL NSTWQGTDLM HNHVLADDDQ SSLDSLGRRS
SLSRLEPSDL SEDSDYDSIW TAHSYRMGST SRSRKESAPQ VLLPEEEKII VEETKSNGQT
VIEEKSLVDT VYALKDEVQE LRQDNKKMKK SLEEEQRARK DLEKLVRKVL KNMNDPAWDE
TNL
//
