ID   A0A480X2M3_PIG          Unreviewed;      1037 AA.
AC   A0A480X2M3;
DT   11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Solute carrier family 12 member 4 isoform a {ECO:0000313|EMBL:HDC02483.1};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|EMBL:HDC02483.1};
RN   [1] {ECO:0000313|EMBL:HDC02483.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30723633; DOI=.7717/peerj.6374;
RA   Gilbert D.G.;
RT   "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL   PeerJ 7:E6374-E6374(2019).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC         Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC         Evidence={ECO:0000256|ARBA:ARBA00034453};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   EMBL; DQIR01247005; HDC02483.1; -; Transcribed_RNA.
DR   AlphaFoldDB; A0A480X2M3; -.
DR   Bgee; ENSSSCG00000028609; Expressed in oocyte and 40 other cell types or tissues.
DR   ExpressionAtlas; A0A480X2M3; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR000622; KCC1.
DR   InterPro; IPR000076; KCL_cotranspt.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   NCBIfam; TIGR00930; 2a30; 1.
DR   PANTHER; PTHR11827:SF46; SOLUTE CARRIER FAMILY 12 MEMBER 4; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 2.
DR   Pfam; PF03522; SLC12; 2.
DR   PRINTS; PR01081; KCLTRNSPORT.
DR   PRINTS; PR01082; KCLTRNSPORT1.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|ARBA:ARBA00023214};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW   Symport {ECO:0000256|ARBA:ARBA00022847};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022847}.
FT   DOMAIN          115..251
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          369..646
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          660..776
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          792..1037
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
SQ   SEQUENCE   1037 AA;  115546 MW;  B61B0845B78F53FB CRC64;
     MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RADREDSDGH GNQKESSPFL CPMEASRGND
     YCDRNLALFE EELDIRPKVS SLLGKLVSYT NLTQGAKEHE EAESGEGTRR RAAKTLLTAI
     SMSAIATNGV VPAGGSYFMI SRSLGPEFGG AVGLCFYLGT TFAAAMYILG AIEILLTYIA
     PPAAIFYPTG THDTSSATLN NMRVYGTIFL TFMTLVVFVG VKYVNKFASL FLACVIISIL
     SIYAGGIKSI FDPPVFPVCM LGNRTLSRDQ FDVCAKTVMV DNETVTTRLW SLFCHSPNLT
     ADSCDPYFLL NNVTEIPGIP GAAASVLQEN LWSAYLEKGE VVEKHGLPST DALGLKESLP
     LYVVADIATS FTVLVGIFFP SVTGIMAGSN RSGDLRDAQK SIPVGTILAI ITTSLVYFSS
     VVLFGACIEG VVLRDKYGDG VSRNLVVGTL AWPSPWVIVI GSFFSTCGAG LQSLTGAPRL
     LQAIAKDNII PFLRVFGHGK ANGEPTWALL LTALIAELGI LIASLDMVAP ILSMFFLMCY
     LFVNLACAVQ TLLRTPNWRP RFKYYHWALS FLGMSLCLAL MFVSSWYYAL VAMLIAGMIY
     KYIEYQGAEK EWGDGIRGLS LSAARYALLR LEEGPPHTKN WRPQLLVLLK LDEDLHVKYP
     RLLTFASQLK AGKGLTIVGS VIQGSFLESY GEAQAAEQTI KNMMEIEKVK GFCQVVVASK
     VREGLAHLIQ SCGLGGMRHN SVVLGWPYGW RQSEDPRAWK TFIDTVRCTT AAHLALLVPK
     NIAFYPSNHE RYLEGHIDVW WIVHDGGMLM LLPFLLRQHK VWRKCRMRIF TVAQMDDNSI
     QMKKDLAIFL YHLRLEAEVE VVEMPNSDIS AYTYERTLMM EQRSQMLRQM RLTKTERERE
     AQLVKDRHSA LRLESLYSDE EDESVAGTDK IQMTWTRDKY MEAEPWDPSH TPDNFRELVH
     IKPDQSNVRR MHTAVKLNEV IVTRSHDARL VLLNMPGPPK NSEGDENYME FLEVLTEGLE
     RVLLVRGGGR EVITIYS
//