ID A0A482R618_9EURY Unreviewed; 387 AA.
AC A0A482R618;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Polycystin cation channel PKD1/PKD2 domain-containing protein {ECO:0000259|Pfam:PF08016};
GN ORFNames=EOO65_02255 {ECO:0000313|EMBL:RYE84444.1};
OS Methanosarcinales archaeon.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales.
OX NCBI_TaxID=2250255 {ECO:0000313|EMBL:RYE84444.1, ECO:0000313|Proteomes:UP000293923};
RN [1] {ECO:0000313|EMBL:RYE84444.1, ECO:0000313|Proteomes:UP000293923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PMG_077 {ECO:0000313|EMBL:RYE84444.1};
RX PubMed=30498029; DOI=.1073/pnas.1812668115;
RA Crombie A.T., Larke-Mejia N.L., Emery H., Dawson R., Pratscher J.,
RA Murphy G.P., McGenity T.J., Murrell J.C.;
RT "Poplar phyllosphere harbors disparate isoprene-degrading bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 115:13081-13086(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RYE84444.1}.
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DR EMBL; SECH01000159; RYE84444.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A482R618; -.
DR Proteomes; UP000293923; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF7; SD02261P; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000293923};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 300..383
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..103
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 42634 MW; 4E278CBF005A6B8C CRC64;
MRSMAQTAAA RHTVMRAKRH ALKSRHAAVD ASSSRDVSAA LQGFTRGRRL SNISSSSSRT
SRRSRSSSSS SSSSSSRSSS RRLGGSGRRA SRLRRRRRRS VRSVPREVAH SPAYGTSSSN
AFHKRREDDI SRLAEGGAAP QLVDALNDGS SPVDAEAGTA VLKRQGFAGV LRSASQRLLT
ITAPVDHEPP EYDDGVFGVS SSMDAAKTPG VLGVVRKHVD WSQPDMVRPT MFARRRVLKR
DPVLMSIHRL RHAARHVRHD HLLSLMGPWW FMATAANTCS VVYAAMALIL GEAAVPGAGR
LLLAFAAFLD WIMLLQYFKY NGHYSLMMRT MKMGLPAIIQ NVTGALPIFF SFIVICVVFF
GQYTERFDNI AWSAISLFAV RCHGERF
//
