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Database: UniProt
Entry: A0A482VLJ1_9CUCU
LinkDB: A0A482VLJ1_9CUCU
Original site: A0A482VLJ1_9CUCU 
ID   A0A482VLJ1_9CUCU        Unreviewed;       355 AA.
AC   A0A482VLJ1;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   RecName: Full=Malate dehydrogenase, mitochondrial {ECO:0000256|ARBA:ARBA00016075};
DE            EC=1.1.1.37 {ECO:0000256|ARBA:ARBA00012995};
GN   ORFNames=BDFB_005029 {ECO:0000313|EMBL:RZC33645.1};
OS   Asbolus verrucosus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Pimeliinae; Asbolus.
OX   NCBI_TaxID=1661398 {ECO:0000313|EMBL:RZC33645.1, ECO:0000313|Proteomes:UP000292052};
RN   [1] {ECO:0000313|EMBL:RZC33645.1, ECO:0000313|Proteomes:UP000292052}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Butters {ECO:0000313|EMBL:RZC33645.1};
RC   TISSUE=Head and leg muscle {ECO:0000313|EMBL:RZC33645.1};
RA   Rider S.D.;
RT   "Genome of the blue death feigning beetle - Asbolus verrucosus.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 1 family.
CC       {ECO:0000256|ARBA:ARBA00008824}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RZC33645.1}.
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DR   EMBL; QDEB01087195; RZC33645.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A482VLJ1; -.
DR   STRING; 1661398.A0A482VLJ1; -.
DR   Proteomes; UP000292052; Unassembled WGS sequence.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11540; MALATE AND LACTATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR11540:SF16; MALATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR   SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|PIRSR:PIRSR000102-3};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003369};
KW   Reference proteome {ECO:0000313|Proteomes:UP000292052};
KW   Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT   DOMAIN          1..144
FT                   /note="Lactate/malate dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00056"
FT   DOMAIN          146..307
FT                   /note="Lactate/malate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02866"
FT   ACT_SITE        176
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
FT   BINDING         7..13
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT   BINDING         33
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT   BINDING         93
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
SQ   SEQUENCE   355 AA;  38681 MW;  434B8928FF4CC4F2 CRC64;
     MKVTVLGAGG KLGKAVSLML KQSPFIDELC LYDNKSLSGF VNDLNYVDTK CRVTTYFGLK
     DINRALSRSN VVVILAAASH TSTHNYNSMF EKNAHVIKEL AVNVAKFTPR SVIAIGTEPI
     NSIVPMFSEI MKKHGHYNPF AIFGITTIDV VRANKFVAEV MGIDPECVVV PIIGGHTEKT
     IVPVLSQASP CNEFSNDELE DITNCVRGAT DNLIKVRSSD GAYLSNAFAT ARFVLSLVKA
     LRGQNNIVEC AYVKSSAHPQ LKYMVTPLLL GPGGITKNLG IPELTDYELC LFENAIPLLA
     EHIKKGEFVG GRPMDMVKGK LEDKPLCDPC DPNPKAPKCP PDHCELQSMI AGDKR
//
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