ID A0A482WCJ2_9CUCU Unreviewed; 852 AA.
AC A0A482WCJ2;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 22-FEB-2023, entry version 12.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891, ECO:0000256|RuleBase:RU362092};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891, ECO:0000256|RuleBase:RU362092};
GN ORFNames=BDFB_010613 {ECO:0000313|EMBL:RZC42173.1};
OS Asbolus verrucosus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Pimeliinae; Asbolus.
OX NCBI_TaxID=1661398 {ECO:0000313|EMBL:RZC42173.1, ECO:0000313|Proteomes:UP000292052};
RN [1] {ECO:0000313|EMBL:RZC42173.1, ECO:0000313|Proteomes:UP000292052}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Butters {ECO:0000313|EMBL:RZC42173.1};
RC TISSUE=Head and leg muscle {ECO:0000313|EMBL:RZC42173.1};
RA Rider S.D.;
RT "Genome of the blue death feigning beetle - Asbolus verrucosus.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Introduces a single-strand break via transesterification at a
CC target site in duplex DNA. Releases the supercoiling and torsional
CC tension of DNA introduced during the DNA replication and transcription
CC by transiently cleaving and rejoining one strand of the DNA duplex. The
CC scissile phosphodiester is attacked by the catalytic tyrosine of the
CC enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme
CC intermediate and the expulsion of a 3'-OH DNA strand.
CC {ECO:0000256|RuleBase:RU362092}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213,
CC ECO:0000256|RuleBase:RU362092};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446, ECO:0000256|RuleBase:RU362092}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RZC42173.1}.
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DR EMBL; QDEB01010189; RZC42173.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A482WCJ2; -.
DR STRING; 1661398.A0A482WCJ2; -.
DR Proteomes; UP000292052; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR PANTHER; PTHR11390:SF20; DNA TOPOISOMERASE 3-BETA-1; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU362092};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362092};
KW Reference proteome {ECO:0000313|Proteomes:UP000292052};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029,
KW ECO:0000256|RuleBase:RU362092}.
FT DOMAIN 3..156
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 822..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 852 AA; 95609 MW; 99C10B19643B3E7B CRC64;
MKTVLMVAEK PSLAASLANI LSNGSNSTRK GSNGICSVHE WNGTFRGTPA RLKMTSVCGH
VMGVDFISKY NNWDRVDPVE LFSCPIEKKE ATPKFKMPMF LSHEAKGCDN LVLWLDCDKE
GENICFEVMQ CVARSMSGDV FSNSVTYRAK FSAITEQDIK AAFNNLSHPN ENEAKSVDAR
QELDLRIGCA FTRFQTKFFQ GRYGDLDSSL ISYGPCQTPT LGFCVQRHDQ IQTFKPESYW
VIKVTIKTKD GDDVNLEWKR IRCFDKEVAN MFLQQIKNQT EAKVVSVVAK EKSKPRPVAL
NTVELMRVAS SGLGMGPHHA MQIAEKLYTQ GYISYPRTET TRYPENFDLV GVLRQQQNSS
EWGEDVREIL SKGVNRPKQG HDAGDHPPIT PMKLASRNEL DSESWKLYDY IARHFIATLA
RDCKYLSTTA TVVINDETFT VTGKTLLDPG YTTVMTWQAF DKNEIVPNLS ENELVPIKDM
RLSEHQTSPP DYLTEAELIT LMETHGIGTD ASIPVHINNI SQRNYVTVTS GRRLKPTTLG
IVLVHGYQKI DAELVLPTMR SAVEEQLNLI AIGKANFQAV LRHTVDIFRL KFQYFVKNID
GMDQLFEVSF SPLSASGKAH SRCGKCRRYM KYIQAKPPRL HCPQCDDTYS LPQNGTVKLF
KELKCPLDDF ELLCWTMGNK GKSFVFCPYC YNHPPFKDMK KGNGCNSCSH PTCPYSLNSN
GVCSCVECDA GVLVLDPSSG PKWKLGCTRC DTIINFFDDA QKITVLSDVC DCGAQLVNVE
YKSEKTKLPN SSSEMKGCVF CTAEFGKLVD KPKTAVYVRS RPFRGGKAPN RGRGRSRAKP
KDKMAQLAAY FV
//