ID A0A482X8D7_LAOST Unreviewed; 1333 AA.
AC A0A482X8D7;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=phosphoribosylformylglycinamidine synthase {ECO:0000256|ARBA:ARBA00012747};
DE EC=6.3.5.3 {ECO:0000256|ARBA:ARBA00012747};
DE AltName: Full=Formylglycinamide ribonucleotide amidotransferase {ECO:0000256|ARBA:ARBA00032632};
DE AltName: Full=Formylglycinamide ribotide amidotransferase {ECO:0000256|ARBA:ARBA00029823};
GN ORFNames=LSTR_LSTR006657 {ECO:0000313|EMBL:RZF42064.1};
OS Laodelphax striatellus (Small brown planthopper) (Delphax striatella).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Auchenorrhyncha; Fulgoroidea;
OC Delphacidae; Criomorphinae; Laodelphax.
OX NCBI_TaxID=195883 {ECO:0000313|EMBL:RZF42064.1, ECO:0000313|Proteomes:UP000291343};
RN [1] {ECO:0000313|EMBL:RZF42064.1, ECO:0000313|Proteomes:UP000291343}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lst14 {ECO:0000313|EMBL:RZF42064.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:RZF42064.1};
RX PubMed=29136191; DOI=.1093/gigascience/gix109;
RA Zhu J., Jiang F., Wang X., Yang P., Bao Y., Zhao W., Wang W., Lu H.,
RA Wang Q., Cui N., Li J., Chen X., Luo L., Yu J., Kang L., Cui F.;
RT "Genome sequence of the small brown planthopper, Laodelphax striatellus.";
RL Gigascience 6:1-12(2017).
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC phospho-D-ribosyl)glycinamide: step 1/2.
CC {ECO:0000256|ARBA:ARBA00004920}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the FGAMS family.
CC {ECO:0000256|ARBA:ARBA00008608}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RZF42064.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QKKF02015641; RZF42064.1; -; Genomic_DNA.
DR STRING; 195883.A0A482X8D7; -.
DR InParanoid; A0A482X8D7; -.
DR UniPathway; UPA00074; UER00128.
DR Proteomes; UP000291343; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01740; GATase1_FGAR_AT; 1.
DR CDD; cd02203; PurL_repeat1; 1.
DR CDD; cd02204; PurL_repeat2; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 1.10.8.750; Phosphoribosylformylglycinamidine synthase, linker domain; 1.
DR Gene3D; 3.90.650.10; PurM-like C-terminal domain; 2.
DR Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 2.
DR HAMAP; MF_00419; PurL_1; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR040707; FGAR-AT_N.
DR InterPro; IPR010073; PurL_large.
DR InterPro; IPR041609; PurL_linker.
DR InterPro; IPR010918; PurM-like_C_dom.
DR InterPro; IPR036676; PurM-like_C_sf.
DR InterPro; IPR036921; PurM-like_N_sf.
DR InterPro; IPR036604; PurS-like_sf.
DR NCBIfam; TIGR01735; FGAM_synt; 1.
DR PANTHER; PTHR10099; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR PANTHER; PTHR10099:SF1; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR Pfam; PF02769; AIRS_C; 2.
DR Pfam; PF18072; FGAR-AT_linker; 1.
DR Pfam; PF18076; FGAR-AT_N; 1.
DR Pfam; PF13507; GATase_5; 1.
DR SMART; SM01211; GATase_5; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF109736; FGAM synthase PurL, linker domain; 1.
DR SUPFAM; SSF56042; PurM C-terminal domain-like; 2.
DR SUPFAM; SSF55326; PurM N-terminal domain-like; 2.
DR SUPFAM; SSF82697; PurS-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962,
KW ECO:0000256|PROSITE-ProRule:PRU00605};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Reference proteome {ECO:0000313|Proteomes:UP000291343}.
FT DOMAIN 74..155
FT /note="Phosphoribosylformylglycinamidine synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF18076"
FT DOMAIN 184..233
FT /note="Phosphoribosylformylglycinamidine synthase linker"
FT /evidence="ECO:0000259|Pfam:PF18072"
FT DOMAIN 446..599
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT DOMAIN 864..989
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT ACT_SITE 1165
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1291
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1293
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 1333 AA; 146368 MW; 28F97BBADE6E6E23 CRC64;
MAVIHFYRSP GLSHGAALAK LKELKKVSSL ITGLSTELCF NVELSNPNLS CEDLAKLKWI
LGSPLDKGAL RNKPLPRSDL LQSTVIEIGP RLNFSTAFSS NAVSICQAIG LSQVTRLEQS
IRYIISWDAK GIEISRNVEQ QLVELLHDRM TQMRYLEPIN SFDHGIKPQN WFEVDVMKNG
RRALEEVNDK LGLAFDDWDL DYYTKVFKDR LKRNPTSVEC FDLAQSNSEH SRHWFFKGKM
IIDGESKEGS LIDMIIQTQE NSNPNNVIKF SDNSSSIEGF TVNWLQPSSV IQAGKFVEKR
SRLNPIFTAE THNFPTAVAP FSGATTGTGG RIRDVQAVGR GGHCIAGTAG YSVGNLNIPE
YNLPWEDKSF NYPSNFAKPL EILIEASNGA SDYGNKFGEP LILGYTRSFG MMTSEDERRE
WIKPIMFSGG IGVMEADMSD KMKPEKGMKV VKVGGPVYRI GVGGGSASSV QVQGDNQCEL
DFGAVQRGDA EMGQKLNRFI RACIECPTRN PICSIHDQGA GGNGNVLKEL VEPCGAVIFC
NRFTLGDPSI STLELWGAEY QENNALLIRP DDRSLLSTMA HRERCPINFV GTVTANGKMI
LSEEKNATSQ TFLDETFYKE NLTYPFNLDL DIILGKMPQK VFNLERKSIL LKPVSLPMDI
AVEAALDRVL RLPAVCSKRF LTNKVDRCVT GLIAQQQCVG PLHTPLSNVA VTAMSMMDTV
GVASAIGEQP IKGLIDPAAG ARMTVAEALT NLVFAQITTL KDVKCSGNWM WAAKLPGEGA
ALYDACEAMC QVMAQLGVAV DGGKDSLSMA ARVDAKSIKA PGTLVVSTYA PCPDITLTVT
PDLKSPAFGR EGCLLLIDIS GGKVRLGGSA LLQCYNQLGN CTPDLDQPAV LVNAFNVMQK
LISEKKILAG HDISDGGLVT CLAEMCFGGM SGLKVDLTPR INHADVSPFQ VLFSEELGWV
IEVDESDMNY VQAQFSNAGV LCHSIGKSTG FGMMSKIVIT YGGKCLVESS VLGLIRMWED
TSYRLECRQA NPDCATAEYQ LLEHRTAPQY KLTFNPDDIF PIEGLLKSKP IVAVIREEGS
NGDREMAASL FMAGFEVWDV TMQDLLDKKI TVDMFRGVIF PGGFSYADVL DAAKGWAASL
LFSSQLDKQF SAFAKRKDTF SLGVCNGCQL MALLGWVGGV QSEPGIVLAR NISDRFECRF
STVKIDKSKS IMFEGMEGSV MGVWVAHGEG RFTFRDQSVH DRVRANECCA MSYTTDTGIA
TEQYPCNPNG TPGGIAAICS EDGRHLAVMP HPERCTKLWQ WPYLPPHWRT DYQTSPWMRM
FTNAYNWSIK NSA
//
