ID   A0A483CPE7_9EURY        Unreviewed;       277 AA.
AC   A0A483CPE7;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase {ECO:0000313|EMBL:TAJ44565.1};
GN   Name=thiD {ECO:0000313|EMBL:TAJ44565.1};
GN   ORFNames=CUJ86_04445 {ECO:0000313|EMBL:TAJ44565.1};
OS   Methanofollis fontis.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanomicrobiaceae; Methanofollis.
OX   NCBI_TaxID=2052832 {ECO:0000313|EMBL:TAJ44565.1, ECO:0000313|Proteomes:UP000292580};
RN   [1] {ECO:0000313|EMBL:TAJ44565.1, ECO:0000313|Proteomes:UP000292580}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FWC-SCC2 {ECO:0000313|EMBL:TAJ44565.1,
RC   ECO:0000313|Proteomes:UP000292580};
RA   Teng N.-H., Lai M.-C., Chen S.-C.;
RT   "Isolation and Characterization of Methanofollis Species from Methane Seep
RT   Offshore SW Taiwan.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TAJ44565.1}.
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DR   EMBL; PGCL01000002; TAJ44565.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A483CPE7; -.
DR   OrthoDB; 43786at2157; -.
DR   Proteomes; UP000292580; Unassembled WGS sequence.
DR   GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR   CDD; cd01169; HMPP_kinase; 1.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR   InterPro; IPR013749; PM/HMP-P_kinase-1.
DR   InterPro; IPR029056; Ribokinase-like.
DR   NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR   PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR   PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR   Pfam; PF08543; Phos_pyr_kin; 1.
DR   SUPFAM; SSF53613; Ribokinase-like; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:TAJ44565.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000292580};
KW   Transferase {ECO:0000313|EMBL:TAJ44565.1}.
FT   DOMAIN          14..245
FT                   /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT                   /evidence="ECO:0000259|Pfam:PF08543"
SQ   SEQUENCE   277 AA;  27631 MW;  961918743631891C CRC64;
     MYSIPCALSI AGSDSGGGAG IEADLAAFAA LGVWGTAAVT AVTAQNPGGV AGAWPLPPGA
     VAAQMEAVFA AFPVGAAKTG MLAEAGIIRA VAAALPEGVP LVVDPVMVAT SGARLLAEEA
     ADALIADLIP RAAVVTPNIP EAEALALTEI QSPGDMRAAA EAILAMGAAA VIVKGGHLEG
     EPADLLLDHE GELVLTAPRS PYQVHGSGCC FSASLTAGLA RGMDLREAFA VAKAFTADAI
     RHAVPDLAGR RSVRPLWCGG WGRGTGEEGP GARRFTQ
//