ID A0A483CU70_9EURY Unreviewed; 269 AA.
AC A0A483CU70;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=CRISPR-associated endoribonuclease Cas6 {ECO:0000313|EMBL:TAJ45003.1};
GN Name=cas6 {ECO:0000313|EMBL:TAJ45003.1};
GN ORFNames=CUJ86_06920 {ECO:0000313|EMBL:TAJ45003.1};
OS Methanofollis fontis.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanofollis.
OX NCBI_TaxID=2052832 {ECO:0000313|EMBL:TAJ45003.1, ECO:0000313|Proteomes:UP000292580};
RN [1] {ECO:0000313|EMBL:TAJ45003.1, ECO:0000313|Proteomes:UP000292580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FWC-SCC2 {ECO:0000313|EMBL:TAJ45003.1,
RC ECO:0000313|Proteomes:UP000292580};
RA Teng N.-H., Lai M.-C., Chen S.-C.;
RT "Isolation and Characterization of Methanofollis Species from Methane Seep
RT Offshore SW Taiwan.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE
CC family. {ECO:0000256|ARBA:ARBA00005937}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TAJ45003.1}.
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DR EMBL; PGCL01000002; TAJ45003.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A483CU70; -.
DR OrthoDB; 43942at2157; -.
DR Proteomes; UP000292580; Unassembled WGS sequence.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd21140; Cas6_I-like; 1.
DR Gene3D; 3.30.70.1890; -; 1.
DR Gene3D; 3.30.70.1900; -; 1.
DR InterPro; IPR049435; Cas_Cas6_C.
DR InterPro; IPR010156; CRISPR-assoc_prot_Cas6.
DR InterPro; IPR045747; CRISPR-assoc_prot_Cas6_N_sf.
DR NCBIfam; TIGR01877; cas_cas6; 1.
DR PANTHER; PTHR36984; CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS6 1; 1.
DR PANTHER; PTHR36984:SF1; CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS6 1; 1.
DR Pfam; PF21350; Cas6_I-A; 1.
DR Pfam; PF01881; Cas_Cas6_C; 1.
DR PIRSF; PIRSF005054; PF1131; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Reference proteome {ECO:0000313|Proteomes:UP000292580};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 120..242
FT /note="CRISPR associated protein Cas6 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01881"
FT ACT_SITE 28
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005054-50"
FT ACT_SITE 41
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005054-50"
FT SITE 53
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000256|PIRSR:PIRSR005054-1"
SQ SEQUENCE 269 AA; 30947 MW; 56B4C9AB29FC861D CRC64;
MRIILTLSTD RPLILPTHYN YGIQSLIYGA INDPALQSLV HDTGFIYEKR SFKMFTFSRL
IGPVVHIGNR FQFTSPVTLH LSSPFDNLIQ EIAKYIFERG MVTLHGNELM VTDFQVEQPP
AFGTDHTVRM LSPMVMYTTL ENERRKFRYY LNPWQDEFAE LIHNNLRKKF VSFYKREPVS
SDFALKPLTE MRPELQKVIL YKGGVIKGWI GRYHVHGDPE MLRFAYDAGF GGKNSQGFGC
FAVDDNPRPI DQVVGLTNAP ETGDDRESL
//
