ID A0A484AS98_DRONA Unreviewed; 612 AA.
AC A0A484AS98;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=La-related protein 7 {ECO:0000256|ARBA:ARBA00015867};
DE AltName: Full=La ribonucleoprotein domain family member 7 {ECO:0000256|ARBA:ARBA00029640};
GN ORFNames=AWZ03_014623 {ECO:0000313|EMBL:TDG38952.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG38952.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG38952.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG38952.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG38952.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the LARP7 family.
CC {ECO:0000256|ARBA:ARBA00008680}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG38952.1}.
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DR EMBL; LSRL02001577; TDG38952.1; -; Genomic_DNA.
DR RefSeq; XP_017962683.1; XM_018107194.1.
DR AlphaFoldDB; A0A484AS98; -.
DR STRING; 7232.A0A484AS98; -.
DR GeneID; 108655472; -.
DR KEGG; dnv:108655472; -.
DR OMA; ANASHDW; -.
DR OrthoDB; 169507at2759; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd07323; LAM; 1.
DR CDD; cd12290; RRM1_LARP7; 1.
DR CDD; cd12542; RRM2_LARP7; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045180; La_dom_prot.
DR InterPro; IPR006630; La_HTH.
DR InterPro; IPR014886; La_xRRM.
DR InterPro; IPR034887; LARP7_RRM1.
DR InterPro; IPR034910; LARP7_RRM2.
DR InterPro; IPR002344; Lupus_La.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22792:SF140; LA-RELATED PROTEIN 7; 1.
DR PANTHER; PTHR22792; LUPUS LA PROTEIN-RELATED; 1.
DR Pfam; PF05383; La; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF08777; RRM_3; 1.
DR PRINTS; PR00302; LUPUSLA.
DR SMART; SM00715; LA; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50961; HTH_LA; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS51939; XRRM; 1.
PE 3: Inferred from homology;
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00332}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 48..137
FT /note="HTH La-type RNA-binding"
FT /evidence="ECO:0000259|PROSITE:PS50961"
FT DOMAIN 142..217
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 476..587
FT /note="XRRM"
FT /evidence="ECO:0000259|PROSITE:PS51939"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 69214 MW; 3CABEBACD12AF63A CRC64;
MAAKAGIAEK NDGPEFEKPN TTVAEGEAVV ASTQPTVPTP AKNEGGGRKR KRHLFNAIRG
QMEFYFGDAN LSKDRFLRRF IEKDPYVPLE IFLTFNKIKT LTQDVQQIST SLSNSQLLEL
DESGLKVRRK TALPEHRDVN NKTLYVEALP ATATHDWLKE VFGRYGTVSY VSLPHYPGTR
KIKEFAFIEF EKSSSVEKAL KAYSQIQGVL SVEHTDPSDL ASIRSFQQQQ LQQRNKTSLD
GQESASETNV VVKQPSKREA DKEGIQETVP TKRAKLNTLK DHCEASAREL SKEEISQQSD
NNNEEQNEAT SQKRRRKQKK RLLADKLKPN IEPSASELKI LPKTSWCSLR NKYLNLQRRL
ISEAKSKLWR TSQAQQPMHK CTVMSSQLQA QQQQLIEVKG ICTSGTSSGH EEPEQLNDPG
DVSEVPVPPK RRKRNKTAGV HKMNMNFYGA GGNEADETKL AGRAEDAAQE RPPLFKYQPG
LIVECSLHEP CVNVKDFKAD MRQYADIKYV DIKEGDQVAH LRLVTPNAAE ELVRQLNCAE
IQLKVLRGQP ETQYWRKIEQ DREAKLSKKV RVQQKRGREK VAKMLAKHIK FDDAVDEVIN
DPTTSASIPS DN
//
