ID A0A484AUH0_DRONA Unreviewed; 1490 AA.
AC A0A484AUH0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=P/Homo B domain-containing protein {ECO:0000259|PROSITE:PS51829};
GN ORFNames=AWZ03_014069 {ECO:0000313|EMBL:TDG39510.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG39510.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG39510.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG39510.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG39510.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG39510.1}.
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DR EMBL; LSRL02000998; TDG39510.1; -; Genomic_DNA.
DR STRING; 7232.A0A484AUH0; -.
DR OMA; TYETQDY; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 9.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884:SF13; NEUROENDOCRINE CONVERTASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00261; FU; 10.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT TRANSMEM 1332..1355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 555..694
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 16..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 259
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 298
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 479
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1490 AA; 163585 MW; DAD7BFC56E4722ED CRC64;
MPSTCCEHPT LIIAETDSEA SNTHNNNSKI YNNNSNIGNN SSKASAGQNA KETEKHHLDD
IDIFGAYSIP DEPIYTNEFA VHIPAGKSVA DIIANKYGFT NKGQIGALDD YYLFQHHRVS
KRSLRLSRKH HSALKSESEV KWLQQQHEKI RRKRDGPYQD IPTYSPYHIL RQSNDYVIDQ
QTNTHFSYSP DPVLSTPLGG AHSPRLEYRD VTSHLIFSDP LFKEQWYLNG GAKDGLDMNI
GPAWQKGYTG KGVVVSILDD GIQTNHPDLA QNYDPDASFD INGNDSDPTP QDNGDNKHGT
RCAGEVAAVA FNNYCGVGVA YNASIGGVRM LDGKVNDVVE AQALSLNPGH IDIYSASWGP
EDDGSTVDGP GPLARRAFIY GVTSGRQGKG SIFVWASGNG GRYTDSCNCD GYTNSIFTLS
ISSATQAGFK PWYLEECSST LATTYSSGTP GHDKSVATVD MDGRLRPDHI CTVEHTGTSA
SAPLAAGICA LALEANQNIT WRDMQYLVVY TSRPGPLEKE SGWTLNGVKR KYSHKFGYGL
MDAGAMVALA EQWNTVPPQH ICKSRENNED RKIEGAYGYS LATHMDVNGC AGTINEVRYL
EHVQCRITLR FFPRGNLRIL LTSPMGTTST LLFERPRDIV KSNFDDWPFL SVHYWGEKAE
GRWTLQVING GRRRVNQPGI LSKWQLIFYG TSTQPMRLKS ELLNTQLRNN PIASNPFLFS
SASNIGQPAN EGGNFNTDSY ASYLNYQNLF SSAGSSPEIA TATLDGQNVS AALAAQSPNG
PNGDNNLIQY SCDAECDSLG CYGRGPTQCV ACSHYRLDNT CVSRCPPRSF PNQVGICWPC
HDSCETCAGA GPDSCLTCAP AHLHVTDLAV CLQVCPDGYF EDIKNKTCVP CEPNCASCQD
RPEFCTSCDH HLVMHENKCF SACPLNTYET DENKCAYCHP SCATCNEASE NNCITCRPSR
YAYQNKCLNN CPEGFYADKK RLECLPCHEG CKTCSTNGIC SECLPNWTLN KKDSCIVSGS
ESCSESEYFN LAEGKCNQCH ESCATCNGPL STDCLSCHQN RLLEQSSCVS GCQDGFFMET
GVCTPCLHTC TQCVSRTNCS NCSKGLELQN GECRTTCADG YYSDRGICAK CYLSCHTCSG
PRRNQCVQCP AGWQLAAGEC HPECPEGFYK SEFGCQKCHH YCKTCNGAGP LACSSCPTHF
MLDGGLCMEC LSSQYYDSTT QRCKSCHESC RSCFGPGQYS CKTCAPPFHL DQLNSQCVPC
CPNQTSADNE TSSENCCHCD KDTGECKTVS TAGKRRTVVG SESIFRNVDR SANGDHGNSG
TFALRLDSPL TAITAIAVAI CLLIITIFSI IFAVLQRNSN NVSRNSVRYR KIISRSDGRK
SDPRNEARFI FNVGEDGDET DDNTDDDMDV NVRTVKKVVY EPNGPMYGNE FFIKSTNDID
AVEFHCKDAD DANQNQFDTH HNANIYTENS SPTYMHQVTS SRMNSKVVHS
//
