ID A0A484AVN7_DRONA Unreviewed; 530 AA.
AC A0A484AVN7;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=AWZ03_012862 {ECO:0000313|EMBL:TDG40717.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG40717.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG40717.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG40717.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG40717.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG40717.1}.
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DR EMBL; LSRL02000501; TDG40717.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A484AVN7; -.
DR STRING; 7232.A0A484AVN7; -.
DR OMA; QPENPRN; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd13329; PH_RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR PANTHER; PTHR45872:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192}.
FT DOMAIN 202..397
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 303..333
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 25..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 530 AA; 59970 MW; 724B1B13D007CA2A CRC64;
MTSQSDLNTT ESLESKDIRR ETYCQQHKNA QVSVNRSESY KERLSNKRIR NSRRKTSDPS
LSSRTNEDPG ELGLSTANYT GSSSSSLSSG GGFDSSGTSM EQVTSCVALS TIGTNTHSNA
ANSHQHPNKL VQQQANQHSQ QESSQGTIGS CSSVSNTNFW SVGQPLQRQW NFESDDEDLN
EADWSSIVPV EMLAALTDAE KKRQEIINEI YQTERNHVRT LRLLDRLFFL PLFDSGLLSH
DHLQLLFPPA LISLRDIHGA FEQKLKQRRI EHNHVVKHIG DLLSDMFDGK SGEVLCDHAA
QFCARQQIAL EALKEKRNKD EQLQKLLKKS ESHKACRRLE LKDLLPTVLQ RLTKYPLLFE
NLYKVTIRVL PENTTEADAI QRAVESSKNI LVEVNKAVKA AEDAHKLQNI QRKLDKSSYD
KDEFKKLDLT QHRLVHDGNL TMKKNPSIQL HGLLFENMIV LLTKQDDKYL LKNLHTPLAV
SNKPVSPIMN IDSETLVRQE AADKNSFFLI KTKTSQMLEL RAPSSSECKT
//
