ID   A0A484AWT9_DRONA        Unreviewed;       667 AA.
AC   A0A484AWT9;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=SPX domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=AWZ03_012713 {ECO:0000313|EMBL:TDG40864.1};
OS   Drosophila navojoa (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG40864.1, ECO:0000313|Proteomes:UP000295192};
RN   [1] {ECO:0000313|EMBL:TDG40864.1, ECO:0000313|Proteomes:UP000295192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG40864.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:TDG40864.1};
RX   PubMed=30423125; DOI=.1093/jhered/esy059;
RA   Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT   "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT   the mojavensis Cluster.";
RL   J. Hered. 110:118-123(2019).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC       {ECO:0000256|ARBA:ARBA00009665}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TDG40864.1}.
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DR   EMBL; LSRL02000467; TDG40864.1; -; Genomic_DNA.
DR   RefSeq; XP_017965377.1; XM_018109888.1.
DR   AlphaFoldDB; A0A484AWT9; -.
DR   STRING; 7232.A0A484AWT9; -.
DR   GeneID; 108657319; -.
DR   KEGG; dnv:108657319; -.
DR   OMA; NPYTWLF; -.
DR   OrthoDB; 7162at2759; -.
DR   Proteomes; UP000295192; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd14477; SPX_XPR1_like; 1.
DR   InterPro; IPR004342; EXS_C.
DR   InterPro; IPR004331; SPX_dom.
DR   PANTHER; PTHR10783:SF103; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1; 1.
DR   PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR   Pfam; PF03124; EXS; 1.
DR   Pfam; PF03105; SPX; 2.
DR   PROSITE; PS51380; EXS; 1.
DR   PROSITE; PS51382; SPX; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        238..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        280..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        320..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        350..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        469..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        508..527
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..183
FT                   /note="SPX"
FT                   /evidence="ECO:0000259|PROSITE:PS51382"
FT   DOMAIN          433..637
FT                   /note="EXS"
FT                   /evidence="ECO:0000259|PROSITE:PS51380"
SQ   SEQUENCE   667 AA;  78063 MW;  6BA28B3DB37D225C CRC64;
     MKFGKTFETH LTIEWRQQYM RYTDLKTMIR RGVDGAPTAE GGATDAEINA YQIAFEEQFF
     TECMHELTRV NNFFLEKLAE ARRKHATLKL QLLATARAPG HTFSSYSLQS SQRLPSMVSL
     RDNNSGSNRK LMTQRQLRNA YSEFYLTLVL LQNFQSLNET GFRKICKKYD KYLRSTSGND
     WLEQNVNPAA FTDQRPLEKL IIDVEDLYTY YLAGGDRSRA MTKLRVPPLG QPTPPRMVFR
     AGLALGMFIM LACTTLFSYI RRPPEEKNIE PFIRLYRGPF TWVIFNFFMA ANVAGWQRAG
     VNHVLIFEID PRSHLQPATF LEIACTFGLL WTLSILGFLF HDLINVQDPF VFPLALTLIM
     ITLLINPLPI MNWPARWWTM RLVGRVVTAP LHYVGFADFW MGDQMNSLVT CMADHYYIVR
     FYANCWLRYA SVLFCFEEDM FVPISRCLPA WFRFAQCLRR FRDSGSKSAS YLLNAGKYST
     TFFVVFFSTM RGRTDDGYAN TFSNPYTWFF ILSYIISTIY CYAWDVIKDF GIFKIWRGEH
     LFLREKLVYP QAFYYFVIVE NLVLRCFWAV ELVVLYHKLI TPYNIKTCAS ILEITRSRFI
     WNYIRLENEH LYNCGKFRAT RDIHLASLNA QQERMLENMM GEADGTDPSG SSTRHADERR
     RLAKEYF
//