ID   A0A484AYU7_DRONA        Unreviewed;       861 AA.
AC   A0A484AYU7;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   03-MAY-2023, entry version 13.
DE   RecName: Full=Myotubularin phosphatase domain-containing protein {ECO:0000259|PROSITE:PS51339};
GN   ORFNames=AWZ03_011814 {ECO:0000313|EMBL:TDG41769.1};
OS   Drosophila navojoa (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG41769.1, ECO:0000313|Proteomes:UP000295192};
RN   [1] {ECO:0000313|EMBL:TDG41769.1, ECO:0000313|Proteomes:UP000295192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG41769.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:TDG41769.1};
RX   PubMed=30423125; DOI=.1093/jhered/esy059;
RA   Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT   "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT   the mojavensis Cluster.";
RL   J. Hered. 110:118-123(2019).
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TDG41769.1}.
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DR   EMBL; LSRL02000312; TDG41769.1; -; Genomic_DNA.
DR   RefSeq; XP_017963619.1; XM_018108130.1.
DR   RefSeq; XP_017963620.1; XM_018108131.1.
DR   AlphaFoldDB; A0A484AYU7; -.
DR   STRING; 7232.A0A484AYU7; -.
DR   OMA; APHQLYD; -.
DR   OrthoDB; 5474662at2759; -.
DR   Proteomes; UP000295192; Unassembled WGS sequence.
DR   CDD; cd14537; PTP-MTMR10-like; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807:SF110; FI17948P1; 1.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   Pfam; PF06602; Myotub-related; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000295192}.
FT   DOMAIN          284..707
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
FT   REGION          76..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          758..806
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..117
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        771..794
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   861 AA;  95951 MW;  868B6F169CEB4D77 CRC64;
     MATGSNDMPD HRKRNTFTSY VAPMAGDVRA TADTNEWCLP SDLRDVHLAT PRMLSGEQIV
     ASAPAYMYSP IAPMEGSGNS NSSNSSSSTS NSINTSIGNG NGNGNNSSSS SGGANGQRYS
     RGGHKEATFG LLSVTNFKLA FVPLHGGQSA QSAPLASDLY QGNNFLGRNE VTLNNIDQIY
     TIAEQGRAAS ALQAARMAGT SSRRKKLEPA KQHNLNGRIV ALHIICKNFR LLKFAFQQQD
     SKLSGASDYG KLIASALARF AYPMRHDLSF AYSYQEPYYS TLVGVSMYAS KNDWARELIR
     CGATEWQVVS ASSVPLLQNR LHASKYTLPP HFVIPKCCEV DRFLQLSLAF CDSRAAFWVY
     SYGSSAASLV RLAELQPSSQ QDTKLENIML ELVRKCDERK QLKLIQLTDQ LPSTQDVQRA
     YHKLRRLCTP ETPEKFMLQD DKYLALLEKT NWLLYVSLCL RQASEAAATL RASVTCVLQE
     SNGRDLCCVI SSLTQLLLDP HFRTIDGFQS LVQKEWVALE HPFQRRLGHV YVSNSEQAAD
     SEQSPIFLLY LDCVWQLLQQ FPDEFEFSQT YLTTLWDACF MPIFDTFQFD SQAQRARAVS
     EGRLVLRPVW DWGEQFSEKD KMFFTNPLYQ RQRGDLAASQ NYRRSLAVGG QHKLLSTTGA
     GGPLATSSPS RYTINPQLFA TQSTVPQDRY LQPSHRILDL SVWDQCYYRW LPVLDIRGGG
     QPQVDLFYRL MLSNIAKAQR CIDLQSFEDL PDAFYEAMGE QRPSQQSLRD QDQRQQEEPV
     EYVDGVERRR KTDPSAGGGA STANGLNVVN GGPMQLSTLS SFFPFGSPIA GDAPHELYDI
     LSGSTELLLD TSSILDKSSI V
//