ID A0A484B017_DRONA Unreviewed; 473 AA.
AC A0A484B017;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=ceramide glucosyltransferase {ECO:0000256|ARBA:ARBA00012699};
DE EC=2.4.1.80 {ECO:0000256|ARBA:ARBA00012699};
GN ORFNames=AWZ03_012375 {ECO:0000313|EMBL:TDG41201.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG41201.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG41201.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG41201.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG41201.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006739}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG41201.1}.
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DR EMBL; LSRL02000393; TDG41201.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A484B017; -.
DR STRING; 7232.A0A484B017; -.
DR OMA; HGSMPFH; -.
DR UniPathway; UPA00222; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008120; F:ceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0102769; F:dihydroceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02520; Glucosylceramide_synthase; 1.
DR InterPro; IPR025993; Ceramide_glucosylTrfase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR12726; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR12726:SF0; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF13506; Glyco_transf_21; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 473 AA; 52356 MW; BA8E00837F706467 CRC64;
MSHLPLAVYG FAAFFMIFWF GTWCVHLIAI CYGKYKLHKK LCKLPTESSP LPGVSILKPL
MGVDPNLQHN LETFFTMDYP LYELLFCVED KHDPAIKLVE QLIEKYPQID AQLFVGGSNV
GVNPKINNIH PGYMAAKYDF VMISDSGIKM KNDTLLDMVQ NMSERHALIH QMPFTSDREG
FAATFEKVFF GTVQSRIYLS ADVLGINCHT GMSCLLRKAV IDQLGGLRTF GCYLAEDFFI
AKRVTELGWK MRISNQPALQ NSGLCDIASF QARLIRWAKL RVAMVPTTIL LEPLSECMIL
GALAAWSASL LFKWDPLVFY LVHILCWLLS DWLLLSIVQH GSMPFGKFEF VIGWLFRELT
GPYLFLHALW NPAIRWRTRT FKLHWGGIAY ELPLHSPATD SLTAPLQPAP TLLAASKSSS
STASSLSSSS AAAAAATATP ASAITTTTAT TNTTKGAGLG TLSAAAKQRL LIS
//
