ID A0A484B124_DRONA Unreviewed; 584 AA.
AC A0A484B124;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Thyrotropin-releasing hormone receptor {ECO:0000256|ARBA:ARBA00018873};
DE AltName: Full=Thyroliberin receptor {ECO:0000256|ARBA:ARBA00032251};
GN ORFNames=AWZ03_012055 {ECO:0000313|EMBL:TDG41531.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG41531.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG41531.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG41531.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG41531.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- FUNCTION: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand
CC binding, this G-protein-coupled receptor triggers activation of the
CC phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.
CC {ECO:0000256|ARBA:ARBA00004100}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|ARBA:ARBA00010663, ECO:0000256|RuleBase:RU000688}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG41531.1}.
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DR EMBL; LSRL02000336; TDG41531.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A484B124; -.
DR STRING; 7232.A0A484B124; -.
DR OMA; TINGHCK; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004997; F:thyrotropin-releasing hormone receptor activity; IEA:InterPro.
DR CDD; cd14997; 7tmA_ETH-R; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002120; TRH_rcpt_1.
DR PANTHER; PTHR24243; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24243:SF235; THYROTROPIN-RELEASING HORMONE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01846; TRHRFAMILY.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 45..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 173..440
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 474..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 63732 MW; 7999B7F8E690E32A CRC64;
MAALKAIKIQ SKTNIEYMTT TLLSGCLGVA AASQAVARRR QQPRLILLLV LLPITITVAA
STTTTITTET AITTISPQDA AATRTTTQHA GLSRGAARGD HGAYNTTNSI PAYNNSNNNY
DISSNNASDK GNASASDAFA EGDAEQMLPQ IPSYIRTTAM FFCIIIMLLG VIGNVMVPIV
IVKTKDMRNS TNIFLTNLSI ADLLVLLVCT PTVLVEVNTR PETWVLGHEM CKAVPFVELT
VAHASVLTIL AISFERYYAI CEPLKAGYVC TKARAILICV LAWGIAALFT SPILWVAEYK
LVEYIDGSSV PVCLTQAIGV STVGFFLMTI SVFFVLPFLM LIVLYSIIAR NLISNQGAML
RARPTKPELS LKARKQVVLM LGAVVLSFFI CLLPFRLLTL WIILSTDQTL HDMGLVRYYS
LLYFCRIMLY LNSAMNPILY NLMSTKFRKG FARLCHDVGQ LLWQLLTLES KRRNASESRG
QQSTGSGTNT NSSNATAATN SSILSRSSNR RSSEEISRTR LKIELHLPCG SELEAMAMLQ
HSTLRSKRRP KQQISFDEDT GQAGAAAEEA VVEGNNGAVS RAAV
//