ID A0A484B383_DRONA Unreviewed; 1032 AA.
AC A0A484B383;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Rho GTPase-activating protein 26 {ECO:0008006|Google:ProtNLM};
GN ORFNames=AWZ03_010392 {ECO:0000313|EMBL:TDG43188.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG43188.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG43188.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG43188.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG43188.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG43188.1}.
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DR EMBL; LSRL02000171; TDG43188.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A484B383; -.
DR STRING; 7232.A0A484B383; -.
DR OMA; YALITSQ; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR CDD; cd11882; SH3_GRAF-like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF1; RHO GTPASE-ACTIVATING PROTEIN GRAF; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 228..336
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 350..537
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 970..1030
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 557..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 183..224
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 635..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1032 AA; 112740 MW; 3E2469F4049EE6CB CRC64;
MARSLCNEDG KTTNLMLLST RMKQLAILLN DFNFECIGTA QTDDENVICE SLKRFGAIIG
TIEDEREKML TLADKHIIES LEDFRKKQIG GVKENKKKFD KKTEKFCQSQ ERFLNMSTKK
PENTIQEADA SLGMHEREYI QESLSYVLRI QEVQERIKFE FVEILLAFIS GWLVFYHTAH
EQAEDHRDYL QDLRHKVQKT RENFEEAREK VTELKTKYME KRTKSEEIFT KRGYLFLMEK
KPFKATWTKY YCTFKKQKRE FTMLQFNQMN HSFTRPEARE DEKLTLFSCQ RRASEFEKRF
CFDLTFKERP GIVYTFQALS EKDHRSWLSA MDGTEPTYLV PGKMKATEAY QLDETGFMFV
RRCIQILEGR GLEDEGIYRK SGVGTKINKL LALGMERKDN EDVFTDDKYR DLMESNTIAS
ALKMYLRNLN EPLMTYHYHS GFIEAAKKES LNQRVNEVHK LVYKLPQPNF EMLDMVIRHL
TEVSRKYEKN KMSVFNLGVV FGPTLLRPLE ETVAAILDIK FNNIVINILI ENYERIFKND
PSTGVATAVN AAVSAANLHP SSSSPPTRMP RASQVGKAAS TGGGGGGGGG GSVGRSSLYS
PEQKVYRVLA KSNYQDPTMS SSLQNIPNGM IYAHGPASAS NSTPPGGVTS SSSNTNGGAG
GGGGVGSSLT VVSAHATNGA RPAQMGSMKN LHAMTQNELG GRRSGSSSTD AAAAVYGILG
GGGGPSTNGG AALQAHHATP ATASSNLRHA DYLMATATPV AQSASSSHIY TNASSNRLSL
NDVSPPTATM RKERHLQTSG SSSAVIGSGP QQHPPVQRSH FAYSQAKHYS PVAAASTSSS
NESVCDSLSS NNGLIGVGVG GSGGAALITG GGGGGGGGSS ANVTRLLNAR SSIDYPPITS
QTSSLSTLLG STCDDIVTAT AAPSMIGGSG MGSLTGAGNG SGSTNESADY APTKMHRNRD
INQIKRDLSA GTARVRTLYA CMGESEGELS FEPNQIITNV RFSHEPGWLQ GTLNGKTGLI
PENYVEHLKP YH
//
