ID A0A484B437_DRONA Unreviewed; 2167 AA.
AC A0A484B437;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Myosin-VIIa {ECO:0008006|Google:ProtNLM};
GN ORFNames=AWZ03_010990 {ECO:0000313|EMBL:TDG42581.1};
OS Drosophila navojoa (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7232 {ECO:0000313|EMBL:TDG42581.1, ECO:0000313|Proteomes:UP000295192};
RN [1] {ECO:0000313|EMBL:TDG42581.1, ECO:0000313|Proteomes:UP000295192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Navoj_Jal97 {ECO:0000313|EMBL:TDG42581.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:TDG42581.1};
RX PubMed=30423125; DOI=.1093/jhered/esy059;
RA Vanderlinde T., Dupim E.G., Nazario-Yepiz N.O., Carvalho A.B.;
RT "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in
RT the mojavensis Cluster.";
RL J. Hered. 110:118-123(2019).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDG42581.1}.
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DR EMBL; LSRL02000217; TDG42581.1; -; Genomic_DNA.
DR STRING; 7232.A0A484B437; -.
DR OMA; GFQGRCR; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000295192; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692:SF33; MYOSIN; 1.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000295192};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 63..733
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1008..1245
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1250..1560
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1558..1627
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1701..1849
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1855..2158
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 612..634
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 156..163
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2167 AA; 250246 MW; BD80307DE4197C69 CRC64;
MVIVTRGDYI WIEPASGREF DVAIGARVIS AEGRRIQVRD DDGDEVWLAP ERRIKAMHAS
SVQGVEDMIS LGDLHEAGIL RNLLIRYKEN LIYTYTGSIL VAVNPYQILP IYTGDQIKLY
KERKIGELPP HIFAIGDNAY AHMKRYRQDQ CIVISGESGA GKTESTKLIL QYLAAISGKH
SWIEQQILEA NPILEAFGNA KTIRNDNSSR FGKYIDIHFS ANGVIEGAKI EQYLLEKSRI
VSQNHSERNY HVFYCILAGL SAEEKSRLEL GAAADYKYLT GGNSITCEGR DDAAEFSDIR
SAMKVLLFSD QEIWEIIKLL AALLHCGNIK YKATVVDNLD ATEIPEHINV ERVAGLLGLP
LQPLIDALTR RTLFAHGETV VSTLSREQSV DVRDAFVKGI YGRLFVHIVR KINSAIFKPK
ATSRNAIGVL DIFGFENFDQ NSFEQFCINY ANENLQQFFV QHIFKLEQEE YNHEAINWQH
IEFVDNQDAL DLIAIKQLNI MALIDEEARF PKGTDQTMLA KLHKTHGAHK NYLKPKSDIN
TSFGLNHFAG IVFYDTRGFL DKNRDTFSPD LLHLVSQSAN KFLRQIFAQD IEMGAETRKR
TPTLSTQFRK SLDALMKTLS SCQPFFIRCI KPNELKKPMM FDRGLCCRQL RYSGMMETIR
IRRAGYPIRH GFREFVERYR FLIAGVPPAH RTDCLSATSR ICGMVLGKSD YQLGHTKVFL
KDAHDLFLEQ ERDRVLTRKI LILQRSIRGW VYRRRFLRMR AAAISVQRVW KGYAQRKRYR
SMRVGYMRLQ ALIRSRVLSH RFRHLRGHIV GLQAHARGYL VRREYGNKMW AVIKIQSHVR
RMIAVRRYRK LQLEHKQFAE VLQLRKLEEQ ELLHRGNKNA REIAEQHYRD RLHELERREM
QEQLEDRRRV EVKMNIINDA ARKQEEPVDD GKLVEAMFDF LPDSSSDAPT PHGGRETSVF
NDLPHAQTIN QDDIITPMHI SEDEEDLSEY KFQKFAATYF QGNVNHQYAK KALKHPLLPL
HTQGDQLAAQ ALWITILRFT GDMQEPKYHT MDRMDTTSVM SKVTATLGRN FIRSKEFQEA
QLMGLDPEAF LKQKPRSIRH KLVSLTLKRK NKLGEDVRRR LQDDEYTADS YQSWLQSRPT
SNLEKLHFII GHGILRAELR DEIYCQICKQ LTNNPLKSSH ARGWILLSLC VGCFAPSEKF
VNYLRAFIRE GPPGYAPYCE ERLKRTFNNG TRNQPPSWLE LQATKSKKPI MLPITFMDGN
TKTLLADSAT TARELCNQLS EKITLKDQFG FSLYIALFDK VSSLGSGGDH VMDAISQCEQ
YAKEQGAQER NAPWRLFFRK EIFAPWHEPT TDQVATNLIY QQVVRGVKFG EYRCDKEEDL
AMIAAQQYFI EYGTDMSMER LFTLLPNFIP DFCLSGVDKA IERWAALVLQ AYKKSYYVKD
KIAPLKIKED IVSYAKYKWP LLFSRFYEAY RNSGPNLPKN DVIIAVNWTG VYVVDDQEQV
LLELSFPEIT AVASQKTNKV FTQTFSLSTV RGEEFTFQSP NAEDIRDLVV YFLDGLKKRS
KYVIALQDYR APSDSTSFLS FFKGDLIILE DESCGESVLN NGWCIGRCDR TQERGDFPAE
TVYVLPTLSK PPQDILALFN IEEAHHGRRL SMVSNGGVVE PRDRPHTLME YALDHFRLPP
KRTMSKTLTL SSKRSEELWR YSRDPIKAPL LRKLQSKEEL VEEACFAFAA ILKYMGDLPS
KRPRMGNEIT DHIFDGPLKH EILRDEIYCQ LMKQLTDNRN RMSEERGWEL MWLATGLFAC
SQGLLKELLL FLRTRRHPIS QDSMHRLQKT IRHGQRKYPP HQVEVEAIQH KTTQIFHKVY
FPDDTDEAFE VDSSTRAKDF CNNISQRLSL RTSEGFSLFV KIADKVISVP EGDFFFDFVR
HLTDWIKKAR PIRDGANPQF TYQVFFMKKL WTNTVPGKDR NADLIFHYHQ ELPKLLRGYH
KCSREEASKL AALVFRVRFG ENKQELQAIP QMLRELIPSD IMKMQSTSEW KRSIVASYNQ
DGGMSSEDAK VAFLKIVYRW PTFGSAFFEV KQTTEPNYPE MLLIAINKHG VSLIHPVTKD
ILVTHPFTRI SNWSSGNTYF HMTIGNLVRG SKLLCETSLG YKMDDLLTSY ISLMLTNMNK
NRTIRAN
//
